Prevalence, aetiology, antimicrobial susceptibility testing, and predictors of urinary tract infection among neonates with clinical sepsis: a cross-sectional study

Lugira, Yasintha S.; Kimaro, Fransisca D.; Mkhoi, Mkhoi L.; Mafwenga, Samuel G.; Joho, Angelina A.; Yahaya, James J.

doi:10.1186/s43054-021-00088-6

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Bacteria, parasites, viruses, and fungi are different infectious agents that causes urinary tract infections (UTIs) that exist and proliferate in urinary system sections such as urethra urethritis, bladder cystitis, urine bacteriuria, and kidney pyelonephritis [1]. UTIs might be symptomatic or asymptomatic infections that can transpire in complicated or uncomplicated individuals [2].…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Etiology, Antimicrobial Susceptibility Testing and Predictors of Urinary Tract Infection among Neonates with Clinical Sepsis

Syed¹,

Rashid²,

Khan³

et al. 2023

PJMHS

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Background and Aim: The most common pediatric infection is urinary tract infection (UTI). Neonates who suffer from neonatal sepsis remain among the most vulnerable to death and morbidity, especially in developing countries. The present study aimed to determine the prevalence, etiology, and susceptible antimicrobial agents of UTIs among neonates with clinical sepsis. Patients and Methods: This cross-sectional study was carried out on 128 sepsis diagnosed neonates admitted to the Department of Pediatrics, Microbiology and Infectious Diseases, Niazi Welfare Teaching Hospital, Sargodha from September 2021 to May 2022. All neonates aged ≤ 28 days diagnosed of clinical sepsis and consent provided by their parents/guardian were enrolled. An interviewed based questionnaire was used for data collection from neonate’s parents or caregiver. The questionnaire included information on the socio-demographics and clinical presentations of neonates, as well as maternal history and laboratory examinations. The history is taken from prenatal to postnatal, including birth weight analysis and birth conditions. Neonates underwent general and local examinations to determine their state of consciousness, vital signs, and weight. We examined the abdomen (for tenderness and abdominal distention) and the nervous system (to elicit suckling and motor reflexes). A hematological analyzer was used to test the full blood picture (FBP). SPSS version 27 was used for data analysis. Results: Of the total 128 neonates, there were 76 (59.4%) females and 52 (40.6%) male neonates. The overall mean age was 6.4 ± 0.36 days with majority of neonates 112 (87.5%) were < 7 days. The low birth weight and low Apgar score were found in 13 (10.2%) and 16 (12.5%) neonates respectively. Of all neonates, the failure to breastfeed was found in 26 (20.3%) being the most common clinical symptom followed by an increase in breathing rate 21 (16.4%), diarrhea 19 (14.8%), gritting 16 (12.5%), altered mental status 12 (9.4%), and jaundice 11 (8.6%). The incidence of UTI was 20.3% (n=26). The prevalence of separated bacterial agents such as Klebsiella pneumonia and Enterobacter spp. was 61.5% (n=16) and 38.5% (n=10) respectively. Ciprofoxacin and amikacin were both effective against 90% and 60% of the bacterial isolates, respectively. The UTI potential predictors involved prolong labour, positive leucocyte esterase test, Low Apgar score, and positive urine nitrite test. Conclusion: The present study found that the prevalence of UTI was 20.3%. Failure to breastfeed was the most common clinical symptom followed by an increase in breathing rate, diarrhea, gritting, altered mental status, jaundice, convulsion, and cyanosis. Klebsiella pneumonia and Enterobacter spp. were the most prevalent separated bacterial agents. Ciprofoxacin and amikacin were both effective in bacterial isolates. Keywords: UTI, Clinical sepsis, Neonates, Antibiotic sensitivity

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Section: Introductionmentioning

confidence: 99%

Prevalence, Etiology, Antimicrobial Susceptibility Testing and Predictors of Urinary Tract Infection among Neonates with Clinical Sepsis

Syed¹,

Rashid²,

Khan³

et al. 2023

PJMHS

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Antibiogram of Urinary Tract Infections and Sepsis among Infants in Neonatal Intensive Care Unit

et al. 2022

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Neonatal infections including sepsis and urinary tract infections are considered among the leading causes of mortality in neonatal intensive care units (NICU). Thus, use of empiric antibiotics is very important in infected neonates and the success of this practice is mainly reliant on the availability of an up-to-date antibiogram for currently used antibiotic drugs. In this study, we aim to determine the bacteriological profile and antibiotic susceptibility pattern of bacteria isolated from blood or/and urine cultures belonging to patients at the NICU. A total of 54 urine samples were collected in the period between January 2015 and December 2019. Data of infants with positive urine and blood bacterial isolates were gathered retrospectively. The most commonly isolated bacteria from urine observed were K. pneumoniae (44%) and E. coli (39%), while Acinetobacter baumannii (33%) and K. pneumoniae (22%) predominated in neonatal blood samples. The majority of uropathogens and blood isolates exhibited low resistance to imipenem and tigecycline, respectively. These antibiotics would be recommended for future use as empirical treatment in neonates with urinary tract infections and/or sepsis. This investigation highlights the importance of surveillance studies to manage and ensure the effectiveness of treatment plan for critically ill infants.

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Prevalence, aetiology, antimicrobial susceptibility testing, and predictors of urinary tract infection among neonates with clinical sepsis: a cross-sectional study

Cited by 2 publications

References 34 publications

Prevalence, Etiology, Antimicrobial Susceptibility Testing and Predictors of Urinary Tract Infection among Neonates with Clinical Sepsis

Prevalence, Etiology, Antimicrobial Susceptibility Testing and Predictors of Urinary Tract Infection among Neonates with Clinical Sepsis

Antibiogram of Urinary Tract Infections and Sepsis among Infants in Neonatal Intensive Care Unit

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