Prevalence, Aetiology and Associated Co-Morbidities of Elevated Aminotransferases in a German Cohort of Orthopaedic Surgery Patients

Löbstein, Sebastian; Kaiser, Thorsten; Liebert, Uwe G.; Wojan, Magdalena; Leichtle, Alexander Benedikt; Mössner, Joachim; Wiegand, Johannes; Tillmann, HL

doi:10.1055/s-2008-1027157

Cited by 17 publications

(15 citation statements)

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“…Through a detailed review of published literature and the analysis of subpopulations, an anti‐HCV prevalence estimate of 0.5% (0.3–0.9%), corresponding to 410 000 (246 000–738 000) anti‐HCV infections, was estimated for 2012 (Table ) . A national study conducted in 2011, the German Health Interview and Examination Survey for Adults (DEGS1), estimated the anti‐HCV prevalence to be 0.3% (0.1–0.5%) .…”

Section: Resultsmentioning

confidence: 99%

Historical epidemiology of hepatitis C virus (HCV) in selected countries

Bruggmann

Berg

Øvrehus

et al. 2014

Journal of Viral Hepatitis

238

192

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SUMMARY. Chronic infection with hepatitis C virus (HCV) is a leading indicator for liver disease. New treatment options are becoming available, and there is a need to characterize the epidemiology and disease burden of HCV. Data for prevalence, viremia, genotype, diagnosis and treatment were obtained through literature searches and expert consensus for 16 countries. For some countries, data from centralized registries were used to estimate diagnosis and treatment rates. Data for the number of liver transplants and the proportion attributable to HCV were obtained from centralized databases. Viremic prevalence estimates varied widely between countries, ranging from 0.3% in Austria, England and Germany to 8.5% in Egypt. The largest viremic populations were in Egypt, with 6 358 000 cases in 2008 and Brazil with 2 106 000 cases in 2007. The age distribution of cases differed between countries. In most countries, prevalence rates were higher among males, reflecting higher rates of injection drug use. Diagnosis, treatment and transplant levels also differed considerably between countries. Reliable estimates characterizing HCV-infected populations are critical for addressing HCV-related morbidity and mortality. There is a need to quantify the burden of chronic HCV infection at the national level.

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Section: Resultsmentioning

confidence: 99%

Historical epidemiology of hepatitis C virus (HCV) in selected countries

Bruggmann

Berg

Øvrehus

et al. 2014

Journal of Viral Hepatitis

238

192

View full text Add to dashboard Cite

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“…Both studies found elevated prevalence in females, although the variance between genders was not statistically significant. A study of 1064 orthopaedic surgery patients in east Germany identified no cases of HCV, indicating the potential of different prevalence rates in West Germany and East Germany (106).…”

Section: Resultsmentioning

confidence: 99%

A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel

Cornberg

Razavi

Alberti

et al. 2011

Liver International

371

294

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Background and Aim: Decisions on public health issues are dependent on reliable epidemiological data. A comprehensive review of the literature was used to gather country-specific data on risk factors, prevalence, number of diagnosed individuals and genotype distribution of the hepatitis C virus (HCV) infection in selected European countries, Canada and Israel. Methodology: Data references were identified through indexed journals and non-indexed sources. In this work, 13 000 articles were reviewed and 860 were selected based on their relevance. Results: Differences in prevalence were explained by local and regional variances in transmission routes or different public health measures. The lowest HCV prevalence ( 0.5%) estimates were from northern European countries and the highest (Z3%) were from Romania and rural areas in Greece, Italy and Russia. The main risk for HCV transmission in countries with wellestablished HCV screening programmes and lower HCV prevalence was injection drug use, which was associated with younger age at the time of infection and a higher infection rate among males. In other regions, contaminated glass syringes and Keywords diagnosis -epidemiology -HCV -hepatitis C -incidence -mortality -prevalence Conclusion: Despite the eradication of transmission by blood products, HCV infection continues to be one of the leading blood-borne infections in the region.Chronic hepatitis C (CHC) is a major health burden in Europe. Recent data suggest that patients with CHC have a higher overall morbidity and mortality (1, 2). A significant portion of liver transplantation in Europe is attributable to cirrhosis and hepatocellular carcinoma because of CHC (3). The socioeconomic impact of hepatitis C virus (HCV) infection is tremendous. The incidence of complications of CHC will not decline over the next 10 years despite improved efficacy of antiviral therapy because most patients with CHC remain undiagnosed (4). Prevention of new infections, HCV screening and early treatment have the potential to reduce the overall morbidity and mortality. However, the cost-effectiveness of HCV screening may depend on the HCV prevalence (5). Decisions on public health issues such as HCV screening and prevention measures are dependent on reliable epidemiological data regarding HCV prevalence and transmission routes. The epidemiological status in Europe is continuously evolving and may vary significantly among the different regions throughout Europe (6). Thus, different countries may need different strategies to reduce the overall burden of HCV infection.Because epidemiological data are the basis for the development of preventive measures, we aimed to systematically identify, review and characterize HCV epidemiology throughout Europe. We included Canada and Israel in our analysis because their healthcare systems and the epidemiological situation are similar to many European countries. MethodsA comprehensive review of the literature was used to gather country-specific data on risk factors, prevalence, number of diagnosed...

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“…The large National Health and Nutrition Examination Survey (NHANES) III study, representing a civilian noninstitutionalized population in the United States, found a prevalence of 13.5% in HCV-and HBV-negative individuals [19]. A German cohort study of orthopedic surgery patients without chronic viral hepatitis noted a prevalence of 11.3% [20] and in HIV-infected persons without viral hepatitis the prevalence was in the same range with 15% [11]. These figures are in accordance with our study with a prevalence of 13.2% in a single ALT measurement at baseline (data not shown).…”

Section: Discussionmentioning

confidence: 99%