Prevalence, aetiology and antibiotic sensitivity profile of asymptomatic bacteriuria isolates from pregnant women in selected antenatal clinic from Nairobi, Kenya

Abstract

IntroductionAsymptomatic bacteriuria (ASB) is the presence of bacteria in urine without apparent symptoms of urinary tract infections. The importance of asymptomatic bacteriuria lies in the insight it provides into symptomatic infections. To determine prevalence, bacterial isolates and Antibiotic Sensitivity Profile of asymptomatic bacterial urinary tract infection in pregnant women in selected clinics in Nairobi.MethodsThis was a cross-sectional study involving women attending antenatal clinic at selected clinics of Nairobi County. The women who met the inclusion criteria were included in the study. The midstream urine samples of these women were subjected to microscopy, culture and sensitivity.ResultsA total of 1020 of women on their first antenatal clinic visit participated in the study; 219 of them had ASB, giving a prevalence of 21.5 % at 95% confidence level. Escherichia coli were the common organism isolated at 38.8%. The majority of the organisms were sensitive to imipenem and gentamycin.ConclusionThere is a high prevalence of ASB among pregnant women included in the study from the Nairobi county clinics. Therefore, routine ASB screening of pregnant women is recommended among the women attending antennal clinics in Nairobi county clinics.

Urinary Tract Infection among Pregnant Women at Pumwani Maternity Hospital, Nairobi, Kenya: Bacterial Etiologic Agents, Antimicrobial Susceptibility Profiles and Associated Risk Factors

“…All the gram-negative isolates except Acinetobacter showed resistance in the range of 89% -100% to Ampicillin and Sulfamethoxazole-Trimethoprim (SXT). These results are similar to those published in two related studies in Kenya indicating that E. coli obtained in Kenya are more resistant to these antimicrobials than among similar isolates encountered in developed countries such as Japan [19]. This is particularly worrying because Sulfamethoxazole/Trimethoprim is heavily relied upon as a prophylaxis against opportunistic infections among individuals infected with HIV in Kenya.…”

“…An alarming finding in this study was the high prevalence of resistance to third generation Cephalosporins among the Gram-negative uropathogens. An earlier study done in Kenya reported similar resistance patterns in uropathogens [19]. This could be attributed to the presence of co-selection of genes conferring resistance to these antibiotics as well as issuance of prescriptions without susceptibility data.…”

Asymptomatic bacteriuria among pregnant women attending antenatal care at Mbale Hospital, Eastern Uganda

“…The second most common isolated organism was Staphylococcus aureus. This is agreement with other studies [4,14] in which Staphylococcus aureus was the second most commonly isolated Uropathogen. However, it disagrees with other studies [27]in which Staphylococci was the most commonly isolated organism.…”

“…Asymptomatic bacteriuria in pregnancy (ASBP) is defined as presence of bacteria in urine of quantitative counts of 10 5 colony forming units/mL without signs and symptoms of urinary tract infection [1]. Globally the prevalence of ASBP is estimated to be 2-11%, although higher rates have been reported in Uganda [3,4]. Women at increased risk of ASBP include women with diabetes mellitus and gestational diabetes, women of low socioeconomic status and past history of urinary tract infection [5].…”

“…E. coli., Staphylococcus epididymis, Staphylococcus aureus, and Klebssiela pnuemoniae were the most common bacteria isolated from women with ASBP [4,12]. However, in Uganda like many other low and middle income countries, screening for ASBP is not done routinely during antenatal care.…”