Preussomerins and Deoxypreussomerins: Novel Inhibitors of Ras Farnesyl-Protein Transferase

Deoxypreussomerins from Jatropha curcas: are they also plant metabolites?

“…Preussomerin and deoxypreussomerins possess a wide range of biological properties including antibacterial, antifungal, herbicidal, antibiotic and antitumor activities (Wipf et al, 2001). Some of the compounds have been identified as novel inhibitors of ras-farnesyl-transferase (Singh et al, 1994).…”

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy

“…Zink et al 39 studied the structure-activity relationships of preussomerin G (101), H (102), I (103), D (104), deoxypreussomerin A (105) and B (106) extracted from the coprophilous fungus Preussia isomera, and the endophytic fungus Harmonema dematioides [123][124][125] which are fungal metabolites. They have a certain inhibitory activity on FTase.…”

“…Chemical structures of terpenoids extracts from Aplidium conicum and their derivatives(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42).…”

“…Compounds 33 and 34 have moderate inhibitory activity against Plasmodium falciparum, and compound 33 also has moderate antiproliferative activity against melanocyte cell lines. To further investigate the structure-activity relationship of thiaplidiaquinones (31-34), Cadelis et al synthesised a series of derivatives (35-50), among which 17 derivatives have inhibitory activity against FTase.The test results show that the derivatives with the farnesyl side chain(39)(40)(41)(42) have stronger FTase inhibitory activity than the derivatives with the isoprene side chain(35)(36)(37)(38)…”

Spirobisnaphthalenes effectively inhibit carbonic anhydrase

“…However, it is assumed that a fungus living in this plant 16 produced this compound. Meanwhile, a large number of such spiro compounds were isolated mostly from endophytic fungi and named diepoxines 1 , Sch plus number 8,17,18 , CJ-plus number 11 , cladosporins [19][20][21] , palmarumycins 3,[22][23][24] , sphaerolones 25 , decaspirones 4,17 and deoxypreussomerin 26 . The interesting structures, various biological activities and potential applications in agriculture, medicine and the food industry attracted the attention of many research groups with respect to the synthesis of spirobisnaphthalenes.…”