Pretreatment with turmeric modulates the inhibitory influence of cisplatin and paclitaxel on CYP2E1 and CYP3A1/2 in isolated rat hepatic microsomes

Ahmed, Enas M.; El-Maraghy, Shohda A.; Teleb, Zakaria A.; Shaheen, Amira

doi:10.1016/j.cbi.2014.05.007

Cited by 11 publications

(7 citation statements)

References 32 publications

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“…People with deficiencies in metabolism enzymes may experience unfavorable physical responses to alcohol, meaning that they will be unlikely to be regular drinkers. The primary alcohol metabolism cytochrome P450 is CYP2E1 [ 33 ]; CYP2E1 is also essential in the metabolism of the anti-cancer drugs cisplatin and etoposide [ 34 , 35 ], which are frequently used in lung cancer chemotherapy. For SCLC, cisplatin plus etoposide is the prioritized first-line regimen [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of alcohol consumption and some other dietary habits for survival in a cohort of Chinese men with lung cancer

Tse

et al. 2017

Chin J Cancer

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BackgroundAlcohol consumption and some other dietary habits are thought to be associated with lung cancer incidence. However, the effects of these habits on lung cancer prognosis have been studied rarely. The purpose of this study was to address these gaps in knowledge.MethodsWe studied a cohort of 1052 Chinese men in Hong Kong who were diagnosed with primary lung cancer. Cox proportional hazards models were used to determine the prognostic values of consumption of alcohol, fresh fruits or vegetables, meat, and fried or preserved food.ResultsCompared with never drinkers, men who drank alcohol 1–3 days per week had a more favorable lung cancer prognosis (hazard ratio [HR]: 0.82, 95% confidence interval [CI] 0.68–0.97); however, this survival advantage was not significant in men who drank alcohol more frequently (HR: 0.91, 95% CI 0.73–1.14). Compared with men who consumed preserved or fried food only occasionally, men who consumed these foods frequently had a higher risk of lung cancer mortality (HR: 1.20, 95% CI 1.00–1.42).ConclusionsOccasional consumption of alcohol was a favorable survival factor for Chinese men with lung cancer. However, this survival benefit did not exist for frequent drinkers of alcohol. Chinese men with lung cancer who were frequent consumers of fried or preserved food had a worse prognosis than those who consumed these foods only occasionally.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of alcohol consumption and some other dietary habits for survival in a cohort of Chinese men with lung cancer

Tse

et al. 2017

Chin J Cancer

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“…Liver microsomes of each rat was prepared by ultracentrifugation [ 43 ]. Phenacetin (50 μM), chlorzoxazone (75 μM), bupropion (75 μM), tolbutamide (150 μM), testosterone (75 μM) and lauric (100 μM) were chosen as the substrates of CYP1A2, CYP 2E1, CYP 2B, CYP2C, CYP3A and CYP4A.…”

Section: Methodsmentioning

confidence: 99%

“…The ESI source settings for ionization of the metabolites were as follows: nebulizer gas, 3 L/min; drying gas, 15.0 L/min; interface, 4.5 kV; CID gas, 230 kPa; DL temperature, 250 °C; heat block temperature, 400 °C. Quantitative analysis was performed by multiple reactions monitoring (MRM) or selective ion scan (SIM) [ 43 ]. Detection mode and MS transitions for the metabolites and internal standards were also shown in Table 5 .…”

Section: Methodsmentioning

confidence: 99%

Effects of Honokiol on CYP450 Activity and Transporter mRNA Expression in Type 2 Diabetic Rats

Wang

Zhai

Chen

2018

IJMS

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This study was aimed to clarify the effect of honokiol (Hon) on the activity of Cytochrome P450 (CYP450) enzymes, and the level of mRNA expression of liver and kidney transporters in type 2 diabetic rats induced by high-fat diet and strepotozotocin. Rats were randomly divided into normal control (NC) group, diabetic control (DC) group and Hon groups (n = 6). The activities of hepatic CYP1A2, CYP2E1, CYP2C, CYP2B, CYP3A and CYP4A, and the mRNA expression levels of hepatic and renal transporters, were determined. Compared to the NC group, the activities of CYP1A2, CYP2E1, CYP4A and CYP2C in DC group were increased by 2.36-, 2.10-, 2.55- and 1.86-fold, respectively. The mRNA expression levels of hepatic Oat2, Oatp2b1 and Oatp1a5, and renal Oct1, Octn2, Oatp2b1 and Oatp1a5, were significantly down-regulated, while the mRNA expression levels of hepatic Octn2, Oatp3a1, Oatp1a1 and Mdr2, and renal Oat2, Mrp4 and Bcrp, were significantly upregulated. Compared to the DC group, Hon treatment significantly inhibited the activity of hepatic CYP2E1, CYP4A, 3A and CYP1A2 by 45.6%, 29.2%, 22.7% and 20.7% in Hon high dose group, respectively. Moreover, Hon treatment significantly inhibited the mRNA expression levels of renal Bcrp and Mrp4 by 2.63-fold and 1.54-fold, while significantly upregulated the mRNA expression levels of hepatic Oat2 and Oatp2b1 by 1.52-fold and 1.54-fold in Hon high dose group, respectively. The results suggested that under the diabetes condition, the changes of CYP450 activity and transporter expression inevitably interfere the normal transport, metabolism and efficacy of drugs. The present work firstly reported that Hon treatment ameliorated the abnormal change of hepatic CYP activity (including CYP2E1, CYP4A and CYP1A2) and the transporter mRNA expression (including hepatic Oat2 and Oatp2b1, renal Bcrp and Mrp4) in type 2 diabetic rats induced by high-fat diet and strepotozotocin, which are associated with the occurrence and development of diabetes.

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“…Polyphenolic agents, such as curcuminoids found in turmeric, work through multiple pathways and have shown improvements in AD symptoms in animal models (Ahmed and Gilani, 2009 , 2014 ; Ahmed et al, 2014 ; Khalid et al, 2017 ), but results of human trials are conflicting (Chen et al, 2018 ). Gingko Biloba extract contains antioxidant flavonoids among other chemicals.…”

Section: Natural Antioxidants For Alzheimer’s Disease Prevention and mentioning

confidence: 99%

Early Detection and Prevention of Alzheimer’s Disease: Role of Oxidative Markers and Natural Antioxidants

Arslan¹,

Jamshed

Qureshi

2020

Front. Aging Neurosci.

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Oxidative stress (OS) contributes to Alzheimer's disease (AD) pathology. OS can be a result of increased reactive oxygen/nitrogen species, reduced antioxidants, oxidatively damaged molecules, and/or a combination of these factors. Scientific literature is scarce for the markers of OS-specific for detecting AD at an early stage. The first aim of the current review is to provide an overview of the potential OS markers in the brain, cerebrospinal fluid (CSF), blood and/or urine that can be used for early diagnosis of human AD. The reason for exploring OS markers is that the proposed antioxidant therapies against AD appear to start too late to be effective. The second aim is to evaluate the evidence for natural antioxidants currently proposed to prevent or treat AD symptoms. To address these two aims, we critically evaluated the studies on humans in which various OS markers for detecting AD at an early stage were presented. Non-invasive OS markers that can detect mild cognitive impairment (MCI) and AD at an early stage in humans with greater specificity and sensitivity are primarily related to lipid peroxidation. However, a combination of OS markers, family history, and other biochemical tests are needed to detect the disease early on. We also report that the long-term use of vitamins (vitamin E as in almonds) and polyphenol-rich foods (curcumin/curcuminoids of turmeric, ginkgo biloba, epigallocatechin-3-gallate in green tea) seem justified for ameliorating AD symptoms. Future research on humans is warranted to justify the use of natural antioxidants.

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Pretreatment with turmeric modulates the inhibitory influence of cisplatin and paclitaxel on CYP2E1 and CYP3A1/2 in isolated rat hepatic microsomes

Cited by 11 publications

References 32 publications

Prognostic value of alcohol consumption and some other dietary habits for survival in a cohort of Chinese men with lung cancer

Prognostic value of alcohol consumption and some other dietary habits for survival in a cohort of Chinese men with lung cancer

Effects of Honokiol on CYP450 Activity and Transporter mRNA Expression in Type 2 Diabetic Rats

Early Detection and Prevention of Alzheimer’s Disease: Role of Oxidative Markers and Natural Antioxidants

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