2014
DOI: 10.1016/j.cbi.2014.05.007
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Pretreatment with turmeric modulates the inhibitory influence of cisplatin and paclitaxel on CYP2E1 and CYP3A1/2 in isolated rat hepatic microsomes

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Cited by 11 publications
(7 citation statements)
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“…People with deficiencies in metabolism enzymes may experience unfavorable physical responses to alcohol, meaning that they will be unlikely to be regular drinkers. The primary alcohol metabolism cytochrome P450 is CYP2E1 [ 33 ]; CYP2E1 is also essential in the metabolism of the anti-cancer drugs cisplatin and etoposide [ 34 , 35 ], which are frequently used in lung cancer chemotherapy. For SCLC, cisplatin plus etoposide is the prioritized first-line regimen [ 36 ].…”
Section: Discussionmentioning
confidence: 99%
“…People with deficiencies in metabolism enzymes may experience unfavorable physical responses to alcohol, meaning that they will be unlikely to be regular drinkers. The primary alcohol metabolism cytochrome P450 is CYP2E1 [ 33 ]; CYP2E1 is also essential in the metabolism of the anti-cancer drugs cisplatin and etoposide [ 34 , 35 ], which are frequently used in lung cancer chemotherapy. For SCLC, cisplatin plus etoposide is the prioritized first-line regimen [ 36 ].…”
Section: Discussionmentioning
confidence: 99%
“…Liver microsomes of each rat was prepared by ultracentrifugation [ 43 ]. Phenacetin (50 μM), chlorzoxazone (75 μM), bupropion (75 μM), tolbutamide (150 μM), testosterone (75 μM) and lauric (100 μM) were chosen as the substrates of CYP1A2, CYP 2E1, CYP 2B, CYP2C, CYP3A and CYP4A.…”
Section: Methodsmentioning
confidence: 99%
“…The ESI source settings for ionization of the metabolites were as follows: nebulizer gas, 3 L/min; drying gas, 15.0 L/min; interface, 4.5 kV; CID gas, 230 kPa; DL temperature, 250 °C; heat block temperature, 400 °C. Quantitative analysis was performed by multiple reactions monitoring (MRM) or selective ion scan (SIM) [ 43 ]. Detection mode and MS transitions for the metabolites and internal standards were also shown in Table 5 .…”
Section: Methodsmentioning
confidence: 99%
“…Polyphenolic agents, such as curcuminoids found in turmeric, work through multiple pathways and have shown improvements in AD symptoms in animal models (Ahmed and Gilani, 2009 , 2014 ; Ahmed et al, 2014 ; Khalid et al, 2017 ), but results of human trials are conflicting (Chen et al, 2018 ). Gingko Biloba extract contains antioxidant flavonoids among other chemicals.…”
Section: Natural Antioxidants For Alzheimer’s Disease Prevention and mentioning
confidence: 99%