Abstract:Background: Activation of angiotensin receptor type1 (AT1R) and xanthine oxidase (XO) generates reactive oxygen species (ROS), that causes cardiac dysfunction after myocardial infarction (MI). However, it remains unknown whether its inhibition could restore the cardiac function after MI. In the present study, we examined effects of irbesartan and topiroxostat on cardiac function after MI. Methods and results: We studied blood pressure and cardiac function in a rat myocardial infraction model using tail cuff sy… Show more
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