Pretreatment with theophylline does not affect adenosine-induced thallium-201 myocardial imaging

Effects of caffeine and theophylline on coronary hyperemia induced by adenosine or dipyridamole

“…As for the interaction of theophylline on adenosine induced coronary hyperemia, this review recommends a conservative approach given the disparity of results between the studies by Heller et al [17] and Nahser et al [12]. Heller et al [17] showed that at therapeutic levels of theophylline (which is 10–20 mg/L) the interpretation of thallium myocardial perfusion imaging tests in patients with previously positive tests while not on theophylline did not change. However, at approximately the same levels of theophylline, Nahser et al [12] revealed a significant reduction in coronary blood flow velocity induced by adenosine as measured by intracoronary doppler.…”

“…Heller et al [17] used thallium (TI) myocardial perfusion imaging (MPI) in a double‐blind, double cross‐over design to indirectly assess the effects of theophylline on adenosine‐induced hyperemia in 16 patients with previously positive TI‐MPI tests. In the theophylline test, adenosine was administered after a 45‐minute infusion of aminophylline (average theophylline concentration was 16 ± 2.7 mg/L).…”

Effect of Caffeine on Ischemia Detection by Adenosine Single-Photon Emission Computed Tomography Perfusion Imaging

“…In a study of 86 patients who underwent vasodilator myocardial perfusion imaging after 24 h of abstinence from caffeine, the frequency of thallium redistribution was similar among patients with caffeine levels of 0 mg/l, 0.1 to 0.9 mg/l, and Ն1 mg/l (12). Heller et al (22) studied the effects of intravenous theophylline on adenosine thallium-201 imaging in 16 patients. Theophylline significantly attenuated the adenosine-induced increase in heart rate, side effects, and ischemic electrocardiographic changes.…”

“…Theophylline significantly attenuated the adenosine-induced increase in heart rate, side effects, and ischemic electrocardiographic changes. However, despite the fact that theophylline is a stronger A2 receptor antagonist than caffeine (23), the size of the perfusion abnormality was unchanged with and without theophylline using segmental analysis or a computerized score (22).…”

Pharmacologic Stress Using Selective A2A Adenosine Receptor Agonists

“…In a study evaluating theophylline pretreatment (another nonselective adenosine receptor antagonist similar to caffeine) and its effect on thallium-201 imaging, researchers demonstrated that theophylline pretreatment reduced increases in heart rate and ischemic changes on electrocardiogram, and did not alter the size or severity of defects noted on adenosine-induced thallium-201 imaging [47]. As for the effect of caffeine on hemodynamics induced by A 2A receptor agonists, it has been shown that 1 to 10 mg/kg caffeine decreased the duration of the CVT-3146 (regadenoson)-induced peak coronary blood flow response, but not the maximum level achieved [48].…”