Abstract:Cardiopulmonary resuscitation (CPR) after cardiac arrest (CA) often leads to neurological deficits in the absence of effective treatment. The aim of the present basic research study was to investigate the effects of human urine-derived stem cells (hUSCs) on the recovery of neurological function in rats after CA/CPR. hUSCs were isolated
in vitro
and identified using flow cytometry. A rat model of CA was established, and CPR was performed. Animals were scored for neurofunctional deficits f… Show more
“…In an animal model of cardioversion ischemic-hypoxic encephalopathy, USCs facilitated neurological function recovery by promoting the expression levels of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) while inhibiting cerebral edema [ 85 ]. Urinary epithelial cell (UEC)-derived induced pluripotent stem cell (iPSC)-developed cerebral organoids (COs) demonstrated a robust capacity for neurogenesis and astrogliogenesis [ 93 ]. Urine-derived iPSCs may hold promise for cell transplantation therapy in stroke by enhancing neurogenesis and alleviating neurological deficits via the miR-26a/HDAC6 axis [ 94 , 95 ].…”
Section: Protection and Regeneration Of Other Vital Organsmentioning
“…In an animal model of cardioversion ischemic-hypoxic encephalopathy, USCs facilitated neurological function recovery by promoting the expression levels of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) while inhibiting cerebral edema [ 85 ]. Urinary epithelial cell (UEC)-derived induced pluripotent stem cell (iPSC)-developed cerebral organoids (COs) demonstrated a robust capacity for neurogenesis and astrogliogenesis [ 93 ]. Urine-derived iPSCs may hold promise for cell transplantation therapy in stroke by enhancing neurogenesis and alleviating neurological deficits via the miR-26a/HDAC6 axis [ 94 , 95 ].…”
Section: Protection and Regeneration Of Other Vital Organsmentioning
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