Pretreatment Quality of Life and Functional Status Assessment Significantly Predict Survival of Elderly Patients With Advanced Non—Small-Cell Lung Cancer Receiving Chemotherapy: A Prognostic Analysis of the Multicenter Italian Lung Cancer in the Elderly Study

Abstract

Pretreatment global QoL and IADL scores, but not ADL and comorbidity, have significant prognostic value for survival of elderly patients with advanced non-small-cell lung cancer who were treated with chemotherapy. Using these scores in clinical practice might improve prognostic prediction for treatment planning.

First line chemotherapy with planned sequential administration of gemcitabine followed by docetaxel in elderly advanced non-small-cell lung cancer patients: a multicenter phase II study

“…In this setting, quality of life evaluation has prognostic value for survival (Maione et al, 2005); nevertheless, in our study we did not report this analysis because of a lack of sufficient questionnaires and quality of life assessment should be recommended in future trials.…”

“…In our study, we did not observe significant differences in overall survival according to Charlson score (0 or 41); although, the Charlson score did not correlate with PS (Dujon et al, 2006), it seems to be insufficient to screen elderly advanced NSCLC patients (Maione et al, 2005). The use of a comprehensive geriatric assessment, according to the recommendations of the SIOG (Extermann et al, 2005), appears crucial to improve the selection and stratification of elderly patients and thereby to allow valid comparisons among different studies.…”

Translation and Validation of the Activities of Daily Living Scale with Iranian Elderly Cancer Patients Treated in an Oncology Unit

“…Those geriatric scales might be made other information on the functional assessment of elderly cancer patients, although their prognostic role in adult old patients with some types of cancers is anonymous (Maione et al, 2005). Meanwhile, there are some weaknesses with the present assessment tools such as the time consuming to complete available tests, the biasing effects of data sources, and the sensitivity of the assessments to range of ability levels (Sainsbury et al, 2005;Gilbertson et al, 2011).…”

Utility of the Edmonton Frail Scale in identifying frail elderly patients during treatment of colorectal cancer

“…The CGA has demonstrated utility for the management of various geriatric problems including prevention of institutionalization and maintenance of independence, prevention of delirium in hospitalized patients, falls, and hospital readmission (15)(16)(17). It can also provide information about life expectancy and functional reserve as well as tolerance to and toxicity of chemotherapy (18,19). Although the CGA may provide additional information about "vulnerability" that clinical judgment and performance status do not, it may not be useful in routine clinical practice due to the time-consuming nature of its administration, and therefore simpler screening methods are required to identify frailty in routine clinical practice.…”