Pretreatment prognostic nutritional index is a significant predictor of prognosis in patients with cervical cancer treated with concurrent chemoradiotherapy

Haraga, Junko; Nakamura, Keiichiro; Omichi, Chiaki; Nishida, Takeshi; Haruma, Tomoko; Kusumoto, Tetsuya; Seki, Nobuhiko; Masuyama, Hisashi; Katayama, Norihisa; Kanazawa, Susumu; Hiramatsu, Yuji

doi:10.3892/mco.2016.1028

Cited by 68 publications

(77 citation statements)

References 33 publications

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“…Finally, a total of 28 articles and 8290 participants were included in this review and meta-analysis. Among them, one concerning cervical cancer was disposed separately cause of providing HRs and survival outcomes for patients with two different treatments [21]. As a consequence, fifteen, nine, and four publications regarding to cervical [19,[21][22][23][24][25][26][27][28][29][30][31][32][33][34], ovarian [35][36][37][38][39][40][41][42][43], and endometrial cancer [44][45][46][47] were enrolled, respectively.…”

Section: Literature Search Results and Characteristicsmentioning

confidence: 99%

Prognostic function of platelet-to-lymphocyte ratio in gynecologic cancers: A systematic review and meta-analysis

Fan

Dai

Wang

et al. 2019

Preprint

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Background: Although along with the diagnosis and treatment level enhanced, current situation of the gynecologic malignancies improved, the risk of gynecologic tumor remains high. Nowadays, inflammatory markers increasingly employed as a tumor predictive factor. Herein, we focused on the association between the platelet-to-lymphocyte ratio (PLR) and gynecological cancers, including cervical, ovarian, and endometrial cancer. Methods: In this meta-analysis, we searched systematically on the EMBASE and PubMed databases from June 1, 1989 to May 31, 2019. After excluded some unqualified articles, we calculated the pooled hazard ratio (HR) with 95% confidence interval (CI) mainly to detect the relationship between PLR and prognostic survival, including overall survival (OS) and progression-free survival (PFS). Random-effect model was adopted when I 2 >50% after Higgins I 2 test. Subgroup analysis and funnel plot were used to seek for the possible source of heterogeneity and publication bias, respectively. All statistical tests were two-sided. Results: After a series of searching and selection, twenty-eight literatures containing 8290 participants totally. Among those recruited trials, 26 studies comprising 8109 patients reported HR for OS and 15 researches enrolled 4283 patients for PFS. Overall, a high value of PLR means a worse OS and PFS in women with gynecologic cancer except those with endometrial cancer for OS (pooled HR =1.35, 95% CI =0.73 to 2.53, P =0.33). Subgroup analyses indicated that the source of heterogeneity may be primarily from the sample size, PLR cut-off, study location, published year, and the cut-off year for the study. Publication bias manifested that bias was not evident. Conclusion: Elevated pretreatment PLR portends a poor prognosis among patients with gynecological tumor, as well as in women with cervical and ovarian malignancies for both OS and PFS. However, in patients with endometrial cancer, this connection is broken for OS but still available for PFS.

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Section: Literature Search Results and Characteristicsmentioning

confidence: 99%

Prognostic function of platelet-to-lymphocyte ratio in gynecologic cancers: A systematic review and meta-analysis

Fan

Dai

Wang

et al. 2019

Preprint

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“…Regarding pathologic variables, we identified tumor size as the strongest prognostic factor affecting PFS and OS in a multivariate analysis. Actually, the size of the tumor has been considered as a strong indicator of recurrence or death in early cervical cancer patients 5 , 35 - 38 . However, the value of tumor size as a prognosticator remains controversial 4 , 6 , 14 , 15 , 39 - 42 .…”

Section: Resultsmentioning

confidence: 99%

Monocytosis as a prognostic factor for survival in stage IB and IIA cervical cancer

Kwon

Kim

et al. 2018

J. Cancer

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Objective: To measure hematologic parameters derived from the white blood cell (WBC) count and differential count (DC) as prognostic factors for survival in patients with stage IB and IIA cervical cancer.Methods: We retrospectively examined demographic, clinicopathologic, and laboratory parameters in a cohort of 233 patients with International Federation of Gynecology and Obstetrics stage IB and IIA cervical cancer who underwent surgical resection. We further assessed the effects of the WBC count and DC-derived hematologic parameters on progression-free survival (PFS) and overall survival (OS) after controlling for other parameters.Results: Patients were followed up for a median of 46.6 months (range, 9-142 months). The Kaplan-Meier estimates of PFS and OS at 5 years were 88.5% and 92.3%, respectively. In a multivariate analysis, we identified the absolute monocyte count (AMC) (hazard ratio [HR], 11.78; P <0.001) and tumor size (HR, 5.41; P = 0.003) as the strongest prognostic factors affecting PFS. We also identified AMC (HR, 23.29; P <0.001), tumor size, (HR, 5.27; P = 0.033), and lymph node involvement (HR, 3.90; P = 0.027) as the strongest prognostic factors affecting OS. AMC remained prognostic with respect to PFS or OS in a Cox model that controlled for the neutrophil-lymphocyte ratio or lymphocyte-monocyte ratio, although neither ratio was a significant prognostic factor for survival.Conclusions: Monocytosis and an increased tumor size were found to be independent prognostic factors affecting both PFS and OS in patients with stage IB and IIA cervical cancer.

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“…At the moment, certain laboratory indexes have been validated as prognostic indicators in cervical cancer, including C-reactive protein/albumin ratio (CAR), neutrophil-tolymphocyte ratio (NLR) and prognostic nutritional index (PNI). [8][9][10] The albumin (ALB) to alkaline phosphatase (ALP) ratio (AAPR) was first revealed as a prognostic index for hepatocellular carcinoma in 2015 as another available indicator for assessing the nutritional status, inflammation level, and immune response. 11 Subsequently, it has been reported as a novel prognostic factor in different malignant carcinomas, including nasopharyngeal carcinoma, pancreatic ductal adenocarcinoma, breast cancer, lung cancer, and cholangiocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

<p>The Prognostic Significance Of Pretreatment Albumin/alkaline Phosphatase Ratio In Patients With Stage IB-IIA Cervical Cancer</p>

Zhang¹,

Yong²,

Ji³

et al. 2019

OTT

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Background: Pretreatment albumin/alkaline phosphatase ratio (AAPR) has been discussed about its prognostic value in several malignancies, whereas its role in cervical cancer remains unclear. In this study, we attempt to explore the prognostic significance of the AAPR in stage IB-IIA cervical cancer patients who underwent a radical hysterectomy. Patients and methods: A total of 230 cervical cancer patients were enrolled in this retrospective study. The threshold value of AAPR was determined by receiver operating characteristic (ROC) curve. Kaplan-Meier survival analysis and multivariate analysis were performed to identify independent prognostic predictors of disease-free survival (DFS) and overall survival (OS). Results: The optimal cutoff value of the preoperative AAPR was 0.68. Patients with AAPR<0.68 showed obviously inferior OS and DFS than those with AAPR>0.68 according to Kaplan-Meier curves (DFS: P = 0.011; OS: P = 0.017). In multivariate analysis, the preoperative AAPR showed to be an independent predictive factor for disease-free survival (DFS: P = 0.015) and overall survival (OS: P = 0.019). Moreover, subgroup analysis revealed that the lower AAPR was correlated with worse prognosis in patients with histologic grade I-II; but in those with histologic grade III, there was no significant difference between the two groups. Conclusion: Preoperative AAPR was a potentially valuable prognostic index in stage IB-IIA cervical cancer patients. Further prospective studies are required to validate its prognostic value.

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Pretreatment prognostic nutritional index is a significant predictor of prognosis in patients with cervical cancer treated with concurrent chemoradiotherapy

Cited by 68 publications

References 33 publications

Prognostic function of platelet-to-lymphocyte ratio in gynecologic cancers: A systematic review and meta-analysis

Prognostic function of platelet-to-lymphocyte ratio in gynecologic cancers: A systematic review and meta-analysis

Monocytosis as a prognostic factor for survival in stage IB and IIA cervical cancer

<p>The Prognostic Significance Of Pretreatment Albumin/alkaline Phosphatase Ratio In Patients With Stage IB-IIA Cervical Cancer</p>

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