Pretreatment prognostic factors for survival in small-cell lung cancer: A new prognostic index and validation of three known prognostic indices on 341 patients

Abstract

A new prognostic index is proposed allowing identification of three different PG. The feasibility of three known prognostic models was validated and demonstrated. Variables other than disease extent or PS (albumin or LDH) should be taken into account in designing future clinical trials.

Relation between the duration of remission and hyperglycemia during induction chemotherapy for acute lymphocytic leukemia with a hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate–cytarabine regimen

“…8 Hyperglycemia, defined as a random baseline serum glucose level Ͼ 110 mg/dL, also was found to have a significant effect on survival in patients with small cell lung carcinoma. 9 Furthermore, improved glycemic control may improve outcome in patients with malignancy because it has been shown to decrease the incidence of microvascular and, most likely, macrovascular complications in patients with noninsulindependent diabetes mellitus. 10 Strict blood glucose control (Յ110 mg/dL) with intensive insulin therapy also has been shown to reduce morbidity and mortality among critically ill patients in a surgical intensive care unit.…”

Pretreatment Serum Albumin Level is an Independent Prognostic Factor in Patients with Stage IIIB Non-Small Cell Lung Cancer: A Study of the Turkish Descriptive Oncological Researches Group

“…In a study including 341 patients with NSCLC in 1997, Maestu et al (1997) compared three prognostic scoring systems (Royal Marsden Model, London Group Scoring System, and Manchester Scoring System). The authors suggested that albumin and LDH levels might be used in the risk scoring in further studies.…”

“…In addition, the number and localization of metastatic lesions and the impact of these lesions on hepatic synthesis were not discussed in these studies. However, hepatic metastasis-related hepatic dysfunction is a well-known cause of hypoalbuminemia (Maestu et al, 1997;Matsunuma et al, 2014).…”

“…Previous studies have shown that serum albumin level may have an adverse prognostic impact on certain cancer types and different cancer stages and that hypoalbuminemia is associated with poor prognosis (Gupta et al, 2009;Gupta and Lis, 2010;Ku et al, 2014;Zhang et al, 2014) In addition, the studies including patients with lung cancer have demonstrated that serum albumin level may play an important role in the scoring systems in metastatic patients (Espinosa et al, 1995;Maestu et al, 1997;Lai et al, 1998;Forrest et al, 2005;Win et al, 2008). The possible relationship between cancer and inflammation has been also widely studied in clinical trials (Lai et al, 1998).…”

“…Serum albumin level, a critical inflammatory negative phase reactant, has been often investigated in the prognostic index models in patients with cancer. Similarly, certain inflammatory markers including C-reactive protein, distribution and rates of platelets, fibrinogen and blood cells have been co-studied with serum albumin level in scoring systems (Espinosa et al, 1995;Maestu et al, 1997;Lai et al, 1998). Some authors have also suggested that cancer cachexia is significantly associated with hypoalbuminemia (O'Gorman et al, 2000;McMillan et al, 2001).…”