Pretreatment Plasma D-Dimer, Fibrinogen, and Platelet Levels Significantly Impact Prognosis in Patients With Epithelial Ovarian Cancer Independently of Venous Thromboembolism

Man, Ya-Nan; Wang, Yanan; Hao, Jin; Liu, Xiaohui; Liu, Chang; Zhu, Chuandong; Wu, Xiaoqing

doi:10.1097/igc.0000000000000303

Cited by 68 publications

(76 citation statements)

References 44 publications

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“…Plasma D-dimer levels have been shown to be increased in patients with gastric (29), colorectal (30), lung (31,32), ovarian (33) and breast cancer (34). Oya et al (13) demonstrated that D-dimer level is associated with the depth of tumor invasion at the time of surgical excision in patients with colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of coagulation factors in operable colorectal cancer

Lee

Huh

et al. 2017

Oncology Letters

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Abnormal hemostasis in cancer patients has prev iously been studied. The primary objective of the present study was to evaluate the association between preoperative hemostasis markers and clinicopathological parameters, and to identify a hemostasis marker affecting survival in patients following curative resection for colorectal cancer. A total of 170 patients who underwent curative surgery for colorectal carcinoma were evaluated. Preoperative coagulation tests included platelet, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer and fibrinogen degradation product (FDP). The clinicopathological variables, including age, gender, tumor location (rectum/colon), tumor size (≥5 cm vs. <5 cm), depth of tumor invasion, lymph node metastasis, stage, lymphovascular invasion, margin involvement and histological differentiation were analyzed. The median age of analyzed patients was 63 years (range, 28–84). The male to female ratio was 62:38. Increased levels of plasma fibrinogen, PT and platelet count (PLT) were associated with larger tumor size (P<0.001, P=0.015 and P=0.002, respectively). Increased plasma fibrinogen levels were significantly associated with depth of tumor invasion and stage (P=0.014 and P=0.048, respectively). Increased plasma D-dimer and FDP levels were significantly associated with tumor node metastasis stage (P=0.031 and P=0.002, respectively). Prolonged PT level (≥11.7 sec), hyper-fibrinogenemia (≥327 mg/dl), high D-dimer level (≥1.3 µg/ml) and increased FDP level (≥2.7 µg/ml) were the prognostic factors associated with shorter survival. Preoperative plasma fibrinogen level was significantly associated with tumor size and depth of tumor invasion. Preoperative plasma prolonged PT level, hyperfibrinogenemia, high D-dimer level and increased FDP level may function as hemostasis markers that predict overall survival in operable patients with colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Clinical significance of coagulation factors in operable colorectal cancer

Lee

Huh

et al. 2017

Oncology Letters

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“…For instance, D‐dimer levels can be utilized as a predictor of immediate mortality in patients with in‐hospital cardiac arrest . An increasing body of evidence suggests the existence of a relationship between activation of coagulation and tumor angiogenesis, progression, and metastatic spread . Fibrinogen and D‐dimer levels are easily obtainable tests commonly ordered for inpatients.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have reported that plasma fibrinogen and/or D‐dimer levels can predict poor prognosis in several types of malignancies including ovarian, breast, colorectal, lung, gastric, and pancreatic cancer . In lung cancer, plasma fibrinogen and D‐dimer levels have been shown to be associated with tumor pathological stage, response to therapy, and survival .…”

Section: Introductionmentioning

confidence: 99%

“…In lung cancer, plasma fibrinogen and D‐dimer levels have been shown to be associated with tumor pathological stage, response to therapy, and survival . In epithelial cell origin ovarian cancer, pretreatment plasma D‐dimer and fibrinogen have been shown to be able to predict disease progression and surgical outcome as well as to help identify and treat high‐risk populations . Recently, pretreatment plasma D‐dimer level was also reported to be an effective predictor of prognosis in natural killer/T‐cell lymphoma .…”

Section: Introductionmentioning

confidence: 99%

“…10 An increasing body of evidence suggests the existence of a relationship between activation of coagulation and tumor angiogenesis, progression, and metastatic spread. [11][12][13][14] Fibrinogen and D-dimer levels are easily obtainable tests commonly ordered for inpatients. D-dimer is a degradation product of the cross-linked fibrin polymer that is degraded by plasmin during fibrinolysis, and it is therefore a measure of both fibrinolysis and coagulability.…”

Section: Introductionmentioning

confidence: 99%

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