Pretreatment of Grape Seed Proanthocyanidin Extract Exerts Neuroprotective Effect in Murine Model of Neonatal Hypoxic-ischemic Brain Injury by Its Antiapoptotic Property

Tu, Xing; Wang, Mengxia; Liu, Yilin; Zhao, Wenyan; Ren, Xuxin; Li, Yuanjun; Liu, Hongqing; Gu, Ziting; Jia, Hui; Liu, Jing; Li, Guoying; Luo, Li

doi:10.1007/s10571-019-00691-7

Cited by 28 publications

(18 citation statements)

References 41 publications

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“…Bijak et al, working with in vitro models, first suggested that extracts could act as a nutraceutical in the prevention of thrombosis [ 65 ]. Under ischemic conditions, neuroprotective effects, reducing brain damage, coupled with an anti-apoptotic activity and proteome preservation have been reported in animals pre-treated with grape seed extracts [ 66 , 67 ]. The role of grape seed extracts in attenuating inflammation and delaying the development of Alzheimer’s or acting as a neuroprotection agent in Parkinson’s disease have been reported [ 68 , 69 ].…”

Section: Grapes Seeds and Seed Extracts: Natural Sources Of Nutrmentioning

confidence: 99%

Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Martín

Grao‐Cruces

Millán-Linares

et al. 2020

Foods

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Wine production is an ancient human activity that generates several by-products, which include some constituents known for their potential in health care and for their role in the food or cosmetic industries. Any variety of grape (Vitis vinifera L.) contains nutrients and bioactive compounds available from their juice or solid parts. Grape seed extract has demonstrated many activities in disease prevention, such as antioxidant effects, which make it a potential source of nutraceuticals. Grape seed is a remarkable winery industry by-product due to the bioactivity of its constituents. Methods for recovery of oil from grape seeds have evolved to improve both the quantity and quality of the yield. Both the lipophilic and hydrophilic chemicals present in the oil of V. vinifera L. make this wine by-product a source of natural nutraceuticals. Food and non-food industries are becoming novel targets of oil obtained from grape seeds given its various properties. This review focuses on the advantages of grape seed oil intake in our diet regarding its chemical composition in industries not related to wine production and the economic and environmental impact of oil production.

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Section: Grapes Seeds and Seed Extracts: Natural Sources Of Nutrmentioning

confidence: 99%

Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Martín

Grao‐Cruces

Millán-Linares

et al. 2020

Foods

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“…Numerous research studies reported that liraglutide suppresses apoptosis and promotes neurological functional recovery in some central nervous system diseases, such as traumatic brain injury (Li et al, 2015) and spinal cord injury (Chen et al, 2017). To the best of our knowledge, caspase 3 is one of the most representative indicators of apoptosis, and cleaved caspase 3 is released at high levels specifically following HI (Feng et al, 2014;Tu et al, 2019). The Bcl-2 family, especially Bcl-2, also protects neurons from apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Treatment With Liraglutide Exerts Neuroprotection After Hypoxic–Ischemic Brain Injury in Neonatal Rats via the PI3K/AKT/GSK3β Pathway

Zeng

Bai

Jiang

et al. 2020

Front. Cell. Neurosci.

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Neonatal hypoxic-ischemic (HI) brain injury is a detrimental disease, which results in high mortality and long-term neurological deficits. Nevertheless, the treatment options for this disease are limited. Thus, the aim of the present study was to assess the role of liraglutide in neonatal HI brain injury in rats and investigate the associated mechanisms. The results showed that treatment with liraglutide significantly reduced infarct volume and ameliorated cerebral edema, decreased inflammatory response, promoted the recovery of tissue structure, and improved prognosis following HI brain injury. Moreover, treatment with liraglutide inhibited apoptosis and promoted neuronal survival both in the rat model and following oxygen-glucose deprivation (OGD) insult. LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), partially reversed these therapeutic effects, suggesting that the PI3K/protein kinase B (Akt) pathway was involved. In conclusion, our data revealed that treatment with liraglutide exerts neuroprotection after neonatal HI brain injury via the PI3K/Akt/glycogen synthase kinase-3β (GSK3β) pathway and may be a promising therapy for this disease.

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“…For example, grape seed proanthocyanidin extract (GSPE) pretreatment alleviated brain damage in an NHIBI model, possibly through its antiapoptotic activity [216].…”

Section: Proanthocyanidinsmentioning

confidence: 99%

From Preclinical Stroke Models to Humans: Polyphenols in the Prevention and Treatment of Stroke

et al. 2020

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Polyphenols are an important family of molecules of vegetal origin present in many medicinal and edible plants, which represent important alimentary sources in the human diet. Polyphenols are known for their beneficial health effects and have been investigated for their potential protective role against various pathologies, including cancer, brain dysfunctions, cardiovascular diseases and stroke. The prevention of stroke promoted by polyphenols relies mainly on their effect on cardio- and cerebrovascular systems. However, a growing body of evidence from preclinical models of stroke points out a neuroprotective role of these molecules. Notably, in many preclinical studies, the polyphenolic compounds were effective also when administered after the stroke onset, suggesting their possible use in promoting recovery of patients suffering from stroke. Here, we review the effects of the major polyphenols in cellular and in vivo models of both ischemic and hemorrhagic stroke in immature and adult brains. The results from human studies are also reported.

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Pretreatment of Grape Seed Proanthocyanidin Extract Exerts Neuroprotective Effect in Murine Model of Neonatal Hypoxic-ischemic Brain Injury by Its Antiapoptotic Property

Cited by 28 publications

References 41 publications

Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Treatment With Liraglutide Exerts Neuroprotection After Hypoxic–Ischemic Brain Injury in Neonatal Rats via the PI3K/AKT/GSK3β Pathway

From Preclinical Stroke Models to Humans: Polyphenols in the Prevention and Treatment of Stroke

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