Pretreatment Nomogram Predicting Ten-Year Biochemical Outcome of Three-Dimensional Conformal Radiotherapy and Intensity-Modulated Radiotherapy for Prostate Cancer

Zeléfsky, Michael J.; Kattan, Michael W.; Fearn, Paul; Fearon, Bertha L.; Stasi, Jason; Shippy, Alison M.; Scardino, Peter T.

doi:10.1016/j.urology.2007.03.060

Cited by 70 publications

(44 citation statements)

References 18 publications

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“…In the study published by Zelefsky et al ( 6 ), the C-index for the nomogram was 0.72, while in our study the area under the ROC curve was only 61%. The reason for this is unclear, but one possible explanation is that our population is different, perhaps representing a narrower range of the spectrum of disease aggressiveness when compared with the populations in which the nomogram was developed and validated.…”

Section: Discussioncontrasting

confidence: 75%

Prostate Cancer: Prediction of Biochemical Failure after External-Beam Radiation Therapy—Kattan Nomogram and Endorectal MR Imaging Estimation of Tumor Volume

et al. 2011

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Purpose:To determine whether magnetic resonance (MR) imaging and MR spectroscopic imaging fi ndings can improve predictions made with the Kattan nomogram for radiation therapy. Materials and Methods:The institutional review board approved this retrospective HIPAA-compliant study. Ninety-nine men who underwent endorectal MR and MR spectroscopy before externalbeam radiation therapy for prostate cancer (January 1998 to June 2007) were included. Linear predictors were calculated with input variables from the study sample and the Kattan original coeffi cients. The linear predictor is a single weighted value that combines information of all predictor variables in a model, where the weight of each value is its association with the outcome. Two radiologists independently reviewed all MR images to determine extent of disease; a third independent reader resolved discrepancies. Biochemical failure was defi ned as a serum prostate-specifi c antigen level of 2 ng/mL (2 m g/L) or more above nadir. Cox proportional hazard models were used to determine the probabilities of treatment failure (biochemical failure) in 5 years. One model included only the Kattan nomogram data; the other also incorporated imaging fi ndings. The discrimination performance of all models was determined with receiver operating characteristics (ROC) curve analyses. These analyses were followed by an assessment of net risk reclassifi cation. Results:The areas under the ROC curve for the Kattan nomogram and the model incorporating MR imaging fi ndings were 61.1% (95% confi dence interval: 58.1%, 64.0%) and 78.0% (95% confi dence interval: 75.7%, 80.4%), respectively . Comparison of performance showed that the model with imaging fi ndings performed signifi cantly better than did the model with clinical variables alone ( P , .001).Overall, the addition of imaging fi ndings led to an improvement in risk classifi cation of about 28%, ranging from approximately a minimum of 16% to a maximum of 39%, depending on the risk change considered important.

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Section: Discussioncontrasting

confidence: 75%

Prostate Cancer: Prediction of Biochemical Failure after External-Beam Radiation Therapy—Kattan Nomogram and Endorectal MR Imaging Estimation of Tumor Volume

et al. 2011

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“…These authors developed a nomogram that improved the prediction accuracy of the published risk stratification models; although the impact of RT and HT variables in the nomogram is limited, particularly the role of the ADT. An update by Zelefsky et al [11] reports similar results.…”

Section: Materials Und Methodenmentioning

confidence: 73%

“…Jedes Nomogramm entspricht einer Kategorie des Gleason-Score, entweder 6, 7, oder 8-10. Alle Nomogramme wurden mittels eines einzigen proportionalen Hazard-Regressionsmodells etabliert, das auch nach Monaten der ADT (0,[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] stratifiziert wurde. Die Aussagekraft dieses Modells wurde anhand von Kalibrierung, unterschiedlicher Behandlung und klinischem Nutzen analysiert.…”

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Three linked nomograms for predicting biochemical failure in prostate cancer treated with radiotherapy plus androgen deprivation therapy

et al. 2015

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“…One center also performed planning CTs in prone position using a belly board. Additional whole pelvic lymph node irradiation was performed by 62 % based on risk scores such as the Roach [22] or MSKCC score [23], by 5 % only in individual cases, by 9 % only in node-positive prostate cancer, and not at all by 24 %.…”

Section: Treatment Planning and Radiation Delivery Techniquesmentioning

confidence: 99%

Consensus and differences in primary radiotherapy for localized and locally advanced prostate cancer in Switzerland

et al. 2015

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Pretreatment Nomogram Predicting Ten-Year Biochemical Outcome of Three-Dimensional Conformal Radiotherapy and Intensity-Modulated Radiotherapy for Prostate Cancer

Cited by 70 publications

References 18 publications

Prostate Cancer: Prediction of Biochemical Failure after External-Beam Radiation Therapy—Kattan Nomogram and Endorectal MR Imaging Estimation of Tumor Volume

Prostate Cancer: Prediction of Biochemical Failure after External-Beam Radiation Therapy—Kattan Nomogram and Endorectal MR Imaging Estimation of Tumor Volume

Three linked nomograms for predicting biochemical failure in prostate cancer treated with radiotherapy plus androgen deprivation therapy

Consensus and differences in primary radiotherapy for localized and locally advanced prostate cancer in Switzerland

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