Pretreatment Esophageal Wall Thickness Associated with Response to Chemoradiotherapy in Locally Advanced Esophageal Cancer

Wongwaiyut, Kraipop; Ruangsin, Sakchai; Laohawiriyakamol, Supparerk; Leelakiatpaiboon, Siriporn; Sangthawan, Duangjai; Sunpaweravong, Patrapim; Sunpaweravong, Somkiat

doi:10.1007/s12029-019-00337-3

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…Measuring one or more layers of the oesophagus is found useful in many circumstances such as assessment of the response to the chemoradiotherapy in oesophageal cancer, characterisation of the strictures and determining the stage of the malignancy. [13][14][15] Furthermore, oesophageal wall thickness measured by endoscopic ultrasonography and wall thickness measurements have previously been related to dysmotility in GERD. 16 Ultrasonography is an effective diagnostic instrument for upper intra-abdominal pathologies.…”

Section: Discussionmentioning

confidence: 99%

“…It can provide detailed images and delicate measurement of the oesophageal layers, but it has the same disadvantages of conventional endoscopy discussed above. Measuring one or more layers of the oesophagus is found useful in many circumstances such as assessment of the response to the chemoradiotherapy in oesophageal cancer, characterisation of the strictures and determining the stage of the malignancy 13‐15 . Furthermore, oesophageal wall thickness measured by endoscopic ultrasonography and wall thickness measurements have previously been related to dysmotility in GERD 16 …”

Section: Discussionmentioning

confidence: 99%

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Ultrasonographic measurement of the thickness of cervical oesophagus layers in the reflux oesophagitis: Association with clinical findings

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Taydaş

Koç³

et al. 2020

Sonography

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Introduction We aimed to evaluate the oesophagus of patients with reflux oesophagitis using ultrasonography and sought associations between the measurements of the mucosa, submucosa and muscularis propria, and endoscopic and clinical findings. Methods Thirty‐nine patients with endoscopically proven reflux oesophagitis and 19 patients with negative endoscopy for oesophagitis were included in the study. Two radiologists assessed the cervical oesophagus at the level of the thyroid gland. The data belonging to the ultrasonographic assessment of the patient group were compared to those of the controls. Results The muscular, submucosal and mucosal thicknesses of the cervical oesophagus measured by two observers significantly differed between the patient and control groups. The P‐values for mucosa, submucosa and muscularis propria were .02, <.001 and <.001, respectively for observer 1, .004, .001 and <.001, respectively for observer 2. The regression analysis showed that among the symptoms of heartburn, regurgitation and dysphagia, heartburn was independently associated with decreased mucosal and submucosal thicknesses of the oesophagus. Discussion Our findings confirmed that the layers of oesophagus in the gastroesophageal reflux disease were thicker compared to those of healthy people. We also found that heartburn was associated with decreased thicknesses of mucosal and submucosal layers in patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ultrasonographic measurement of the thickness of cervical oesophagus layers in the reflux oesophagitis: Association with clinical findings

Yalçın

Taydaş

Koç³

et al. 2020

Sonography

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“…For conventional CT, the identification of esophageal carcinoma usually depends on finding esophagus wall thickening [ 32 ]. Umeoka et al [ 25 ] found that arterial phase CECT images have the advantage of detecting lesions without wall thickening and show the best results in evaluating advanced lesions.…”

Section: Discussionmentioning

confidence: 99%

Can lymphovascular invasion be predicted by contrast-enhanced CT imaging features in patients with esophageal squamous cell carcinoma? A preliminary retrospective study

Yang

Yue

et al. 2022

BMC Med Imaging

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Background To investigate the value of contrast-enhanced CT (CECT)-derived imaging features in predicting lymphovascular invasion (LVI) status in esophageal squamous cell carcinoma (ESCC) patients. Methods One hundred and ninety-seven patients with postoperative pathologically confirmed esophageal squamous cell carcinoma treated in our hospital between January 2017 and January 2019 were enrolled in our study, including fifty-nine patients with LVI and one hundred and thirty-eight patients without LVI. The CECT-derived imaging features of all patients were analyzed. The CECT-derived imaging features were divided into quantitative features and qualitative features. The quantitative features consisted of the CT attenuation value of the tumor (CTVTumor), the CT attenuation value of the normal esophageal wall (CTVNormal), the CT attenuation value ratio of the tumor-to-normal esophageal wall (TNR), the CT attenuation value difference between the tumor and normal esophageal wall (ΔTN), the maximum thickness of the tumor measured by CECT (Thickness), the maximum length of the tumor measured by CECT (Length), and the gross tumor volume measured by CECT (GTV). The qualitative features consisted of an enhancement pattern, tumor margin, enlarged blood supply or drainage vessels to the tumor (EVFDT), and tumor necrosis. For the clinicopathological characteristics and CECT-derived imaging feature analysis, the chi-squared test was used for categorical variables, the Mann–Whitney U test was used for continuous variables with a nonnormal distribution, and the independent sample t-test was used for the continuous variables with a normal distribution. The trend test was used for ordinal variables. The association between LVI status and CECT-derived imaging features was analyzed by univariable logistic analysis, followed by multivariable logistic regression and receiver operating characteristic (ROC) curve analysis. Results The CTVTumor, TNR, ΔTN, Thickness, Length, and GTV in the group with LVI were higher than those in the group without LVI (P < 0.05). A higher proportion of patients with heterogeneous enhancement pattern, irregular tumor margin, EVFDT, and tumor necrosis were present in the group with LVI (P < 0.05). As revealed by the univariable logistic analysis, the CECT-derived imaging features, including CTVTumor, TNR, ΔTN and enhancement pattern, Thickness, Length, GTV, tumor margin, EVFDT, and tumor necrosis were associated with LVI status (P < 0.05). Only the TNR (OR 8.655; 95% CI 2.125–37.776), Thickness (OR 6.531; 95% CI 2.410–20.608), and tumor margin (OR 4.384; 95% CI 2.004–9.717) were independent risk factors for LVI in the multivariable logistic regression analysis. The ROC curve analysis incorporating the above three CECT-derived imaging features showed that the area under the curve obtained by the multivariable logistic regression model was 0.820 (95% CI 0.754–0.885). Conclusion The CECT-derived imaging features, including TNR, Thickness, tumor margin, and their combination, can be used as predictors of LVI status for patients with ESCC.

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“…Wu's team found that in patients with esophageal cancer undergoing radiotherapy and chemotherapy, the percentage of maximum wall thickness reduction was independently associated with pathological complete response ( p = 0.027), and could predict the recurrence of the disease ( 25 ). Wongwaiyut's team found that the survival of patients with esophageal cancer with a maximum wall thickness of <10 mm and ≥10 mm was different, and the larger the maximum wall thickness, the worse the prognosis of patients ( 26 ). We found that the maximum tube wall thickness was lower in the good efficacy group and good prognosis group, but its value in evaluating the short-term efficacy and prognosis of patients with esophageal cancer was not high, and there was no significant difference.…”

Section: Discussionmentioning

confidence: 99%

Application Value of Gastroenterography Combined With CT in the Evaluation of Short-Term Efficacy and Prognosis in Patients With Esophageal Cancer Radiotherapy

Xue

Linning

et al. 2022

Front. Surg.

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PurposeTo observe the application value of gastroenterography combined with CT in the evaluation of short-term efficacy and prognosis in patients with esophageal cancer radiotherapy.MethodsFrom January 2013 to December 2020, the clinical data of 207 patients with esophageal cancer treated by radiotherapy in our hospital were collected retrospectively. All patients received gastroenterography and CT examination before and after radiotherapy, and the patients were followed-up for 1 year, and the evaluation value of their short-term efficacy and prognosis was observed.ResultsAfter radiotherapy, the length diameter, short diameter, and volume of the lymph node were lower than those before radiotherapy (p < 0.05), but the maximum tube wall thickness had no significant difference (p > 0.05). The length diameter, short diameter, and volume of the lymph node, and the maximum tube wall thickness in the good efficacy group and the good prognosis group were lower, and the objective response rate in the good prognosis group was higher (p < 0.05). The area under the curve (AUC) of the length diameter, short diameter, and volume of the lymph node to evaluate the short-term efficacy of patients with esophageal cancer was 0.738, 0.705, and 0.748, respectively, and the AUC to evaluate the prognosis of patients with esophageal cancer was 0.751, 0.776, and 0.791, respectively.ConclusionGastroenterography combined with CT has a good application value in the evaluation of short-term efficacy and prognosis in patients with esophageal cancer radiotherapy.

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Pretreatment Esophageal Wall Thickness Associated with Response to Chemoradiotherapy in Locally Advanced Esophageal Cancer

Cited by 4 publications

References 17 publications

Ultrasonographic measurement of the thickness of cervical oesophagus layers in the reflux oesophagitis: Association with clinical findings

Ultrasonographic measurement of the thickness of cervical oesophagus layers in the reflux oesophagitis: Association with clinical findings

Can lymphovascular invasion be predicted by contrast-enhanced CT imaging features in patients with esophageal squamous cell carcinoma? A preliminary retrospective study

Application Value of Gastroenterography Combined With CT in the Evaluation of Short-Term Efficacy and Prognosis in Patients With Esophageal Cancer Radiotherapy

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