Pretreatment C‐reactive protein/albumin ratio is associated with poor survival in patients with stage <scp>IB</scp>‐<scp>IIA</scp> cervical cancer

Zhang, Weiwei; Liu, Kejun; Ye, Bin; Liang, Wenjie; Ren, Yazhou

doi:10.1002/cam4.1270

Cited by 40 publications

(50 citation statements)

References 33 publications

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“…Recently, an increasing amount of research has been focusing on the effects of systemic inflammatory response (SIR) on oncogenesis, and such research has revealed that there is a significant relationship between SIR and poor tumor-specific survival in numerous cancers. [9][10][11] In particular, the neutrophil to lymphocyte ratio (NLR), which is considered as a biomarker of SIR, has emerged as an independent prognostic factor for biliary tract cancer in operable patients and in advanced disease patients undergoing adjuvant therapy. 12,13 The lymphocyte to monocyte ratio (LMR) is another biomarker of SIR, with a combination of lymphocyte count and monocyte count.…”

Section: Introductionmentioning

confidence: 99%

Lymphocyte to Monocyte Ratio Predicts Resectability and Early Recurrence of Bismuth-Corlette Type IV Hilar Cholangiocarcinoma

Peng

et al. 2020

Journal of Gastrointestinal Surgery

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Background The objective of our research was to investigate the value of the lymphocyte to monocyte ratio (LMR) and its dynamic changes (LMRc) in predicting tumor resectability and early recurrence of radiologically resectable type IV hilar cholangiocarcinoma (HC). Methods A total of 411 patients with radiologically resectable type IV HC were included. Data on their clinicopathologic characteristics, perioperative features, and survival outcomes were analyzed. Receiver operating characteristic (ROC) analysis was conducted to assess the ability of preoperative LMR (pre-LMR) to predict tumor resectability, and the ability of postoperative LMR (post-LMR) to discriminate between early and late recurrence. Survival curves were calculated using the Kaplan-Meier estimate. Univariate and multivariate logistic regression models were used to identify factors associated with resectability and early recurrence. Results Of 411 patients with potentially curative type IV HC, 254 underwent curative surgery. The optimal cutoff value of pre-LMR as an indicator of resectability was 3.67, and the optimal cutoff value of post-LMR for detecting early recurrence was 4.10. In the multivariate logistic regression model, CA19-9 > 200 U/mL, pre-LMR ≤ 3.67, and tumor size > 3 cm were found to be independent risk factors for poor resectability. Moreover, multivariate analysis showed that LMRc, resection margin, AJCC N stage, and lymphovascular invasion were independent risk factors associated with early recurrence. Discussion Pre-LMR is a valuable indicator of resectability and LMRc is a valuable predictor of early recurrence in patients with curative type IV HC.

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Section: Introductionmentioning

confidence: 99%

Lymphocyte to Monocyte Ratio Predicts Resectability and Early Recurrence of Bismuth-Corlette Type IV Hilar Cholangiocarcinoma

Peng

et al. 2020

Journal of Gastrointestinal Surgery

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“…Among them, one concerning cervical cancer was disposed separately cause of providing HRs and survival outcomes for patients with two different treatments [21]. As a consequence, fifteen, nine, and four publications regarding to cervical [19,[21][22][23][24][25][26][27][28][29][30][31][32][33][34], ovarian [35][36][37][38][39][40][41][42][43], and endometrial cancer [44][45][46][47] were enrolled, respectively.…”

Section: Literature Search Results and Characteristicsmentioning

confidence: 99%

Prognostic function of platelet-to-lymphocyte ratio in gynecologic cancers: A systematic review and meta-analysis

Fan

Dai

Wang

et al. 2019

Preprint

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Background: Although along with the diagnosis and treatment level enhanced, current situation of the gynecologic malignancies improved, the risk of gynecologic tumor remains high. Nowadays, inflammatory markers increasingly employed as a tumor predictive factor. Herein, we focused on the association between the platelet-to-lymphocyte ratio (PLR) and gynecological cancers, including cervical, ovarian, and endometrial cancer. Methods: In this meta-analysis, we searched systematically on the EMBASE and PubMed databases from June 1, 1989 to May 31, 2019. After excluded some unqualified articles, we calculated the pooled hazard ratio (HR) with 95% confidence interval (CI) mainly to detect the relationship between PLR and prognostic survival, including overall survival (OS) and progression-free survival (PFS). Random-effect model was adopted when I 2 >50% after Higgins I 2 test. Subgroup analysis and funnel plot were used to seek for the possible source of heterogeneity and publication bias, respectively. All statistical tests were two-sided. Results: After a series of searching and selection, twenty-eight literatures containing 8290 participants totally. Among those recruited trials, 26 studies comprising 8109 patients reported HR for OS and 15 researches enrolled 4283 patients for PFS. Overall, a high value of PLR means a worse OS and PFS in women with gynecologic cancer except those with endometrial cancer for OS (pooled HR =1.35, 95% CI =0.73 to 2.53, P =0.33). Subgroup analyses indicated that the source of heterogeneity may be primarily from the sample size, PLR cut-off, study location, published year, and the cut-off year for the study. Publication bias manifested that bias was not evident. Conclusion: Elevated pretreatment PLR portends a poor prognosis among patients with gynecological tumor, as well as in women with cervical and ovarian malignancies for both OS and PFS. However, in patients with endometrial cancer, this connection is broken for OS but still available for PFS.

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“…36 Prior studies have shown that nutrient deficiency and systematic inflammatory response might play a critical role in the pathogenesis and progression of human carcinomas and were correlated with inferior prognosis in patients undergoing resection for solid tumors. 8,[37][38][39] Zheng et al have demonstrated that ALB is an independent prognostic indicator in early operable cervical cancer. 40 Moreover, a recent published article found that high levels of ALP could influence tumorigenesis and predict outcomes in cervical cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…At the moment, certain laboratory indexes have been validated as prognostic indicators in cervical cancer, including C-reactive protein/albumin ratio (CAR), neutrophil-tolymphocyte ratio (NLR) and prognostic nutritional index (PNI). [8][9][10] The albumin (ALB) to alkaline phosphatase (ALP) ratio (AAPR) was first revealed as a prognostic index for hepatocellular carcinoma in 2015 as another available indicator for assessing the nutritional status, inflammation level, and immune response. 11 Subsequently, it has been reported as a novel prognostic factor in different malignant carcinomas, including nasopharyngeal carcinoma, pancreatic ductal adenocarcinoma, breast cancer, lung cancer, and cholangiocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

<p>The Prognostic Significance Of Pretreatment Albumin/alkaline Phosphatase Ratio In Patients With Stage IB-IIA Cervical Cancer</p>

Zhang¹,

Yong²,

Ji³

et al. 2019

OTT

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Background: Pretreatment albumin/alkaline phosphatase ratio (AAPR) has been discussed about its prognostic value in several malignancies, whereas its role in cervical cancer remains unclear. In this study, we attempt to explore the prognostic significance of the AAPR in stage IB-IIA cervical cancer patients who underwent a radical hysterectomy. Patients and methods: A total of 230 cervical cancer patients were enrolled in this retrospective study. The threshold value of AAPR was determined by receiver operating characteristic (ROC) curve. Kaplan-Meier survival analysis and multivariate analysis were performed to identify independent prognostic predictors of disease-free survival (DFS) and overall survival (OS). Results: The optimal cutoff value of the preoperative AAPR was 0.68. Patients with AAPR<0.68 showed obviously inferior OS and DFS than those with AAPR>0.68 according to Kaplan-Meier curves (DFS: P = 0.011; OS: P = 0.017). In multivariate analysis, the preoperative AAPR showed to be an independent predictive factor for disease-free survival (DFS: P = 0.015) and overall survival (OS: P = 0.019). Moreover, subgroup analysis revealed that the lower AAPR was correlated with worse prognosis in patients with histologic grade I-II; but in those with histologic grade III, there was no significant difference between the two groups. Conclusion: Preoperative AAPR was a potentially valuable prognostic index in stage IB-IIA cervical cancer patients. Further prospective studies are required to validate its prognostic value.

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Pretreatment C‐reactive protein/albumin ratio is associated with poor survival in patients with stage IB‐IIA cervical cancer

Cited by 40 publications

References 33 publications

Lymphocyte to Monocyte Ratio Predicts Resectability and Early Recurrence of Bismuth-Corlette Type IV Hilar Cholangiocarcinoma

Lymphocyte to Monocyte Ratio Predicts Resectability and Early Recurrence of Bismuth-Corlette Type IV Hilar Cholangiocarcinoma

Prognostic function of platelet-to-lymphocyte ratio in gynecologic cancers: A systematic review and meta-analysis

<p>The Prognostic Significance Of Pretreatment Albumin/alkaline Phosphatase Ratio In Patients With Stage IB-IIA Cervical Cancer</p>

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