Pretransplantation Systolic Blood Pressure and the Risk of Delayed Graft Function in Young Living-Related Renal Allograft Recipients

Özdemir, Fatma Nurhan; Ibis, A.; Altunoğlu, Alpaslan; Usluoğulları, Alper; Arat, Z.; Haberal, Mehmet

doi:10.1016/j.transproceed.2007.03.026

Cited by 13 publications

(11 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no association between both predialysis and post-dialysis pre-transplant SBPs and DGF in our study. Ozdemir et al (55) examined 142 renal transplant recipients and found that pre-transplant SBP level of <120 mmHg was associated with a more than three times higher risk of DGF. In addition, when only livingrelated recipients were considered, the SBP level demonstrated a significant positive association with DGF (55).…”

Section: Pre-dialysis Systolic Blood Pressure (Mmhg)mentioning

confidence: 99%

“…Ozdemir et al (55) examined 142 renal transplant recipients and found that pre-transplant SBP level of <120 mmHg was associated with a more than three times higher risk of DGF. In addition, when only livingrelated recipients were considered, the SBP level demonstrated a significant positive association with DGF (55). Potential explanations for the different outcomes seen in our study include the larger size and the lower proportion of living donors in our cohort.…”

Section: Pre-dialysis Systolic Blood Pressure (Mmhg)mentioning

confidence: 99%

See 1 more Smart Citation

Association of pre‐transplant blood pressure with post‐transplant outcomes

Molnar

Foster

Sim

et al. 2013

Clinical Transplantation

View full text Add to dashboard Cite

Background Previous studies have indicated U-shaped associations between blood pressure (BP) and mortality in dialysis patients. We hypothesized that a similar association exists between pre-transplant BP and post-transplant outcomes in dialysis patients who undergo successful kidney transplantation. Methods Data from the Scientific Registry of Transplant Recipients were linked to the 5-year cohort of a large dialysis organization in the United States. We identified all dialysis patients who received a kidney transplant during this period. Unadjusted and multivariate adjusted predictors of transplant outcomes were examined. Results The 13,881 patients included in our study were 47±14 years old and included 42% women. There was no association between pre-transplant systolic BP and post-transplant mortality, although a decreased risk trend was observed in those with low post-dialysis systolic BP. Compared to patients with pre-dialysis diastolic BP 70–<80 mmHg, patients with pre-dialysis diastolic BP<50 mmHg experienced lower risk of post-transplant death (HR:0.74, 95%CI:0.55–0.99). However, compared to patients with post-dialysis diastolic BP 70–<80 mmHg, patients with post-dialysis diastolic BP≥100 mmHg experienced higher risk of death (HR: 3.50, 95%CI: 1.57–7.84). In addition, very low (

show abstract

Section: Pre-dialysis Systolic Blood Pressure (Mmhg)mentioning

confidence: 99%

Section: Pre-dialysis Systolic Blood Pressure (Mmhg)mentioning

confidence: 99%

Association of pre‐transplant blood pressure with post‐transplant outcomes

Molnar

Foster

Sim

et al. 2013

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…There are a number of steps that physicians can take to limit DGF. Table 4 lists risk factors for DGF that should be considered before using sirolimus [32][33][34][35][36][37]. As with the previous sideeffects, efforts to alter the modifiable risk factors should be made.…”

Section: Delayed Graft Functionmentioning

confidence: 99%

Practical recommendations for the early use of m-TOR inhibitors (sirolimus) in renal transplantation

Campistol

Cockwell

Diekmann

et al. 2009

Transplant International

View full text Add to dashboard Cite

Summary m‐TOR inhibitors (e.g. sirolimus) are well‐tolerated immunosuppressants used in renal transplantation for prophylaxis of organ rejection, and are associated with long‐term graft survival. Early use of sirolimus is often advocated by clinicians, but this may be associated with a number of side‐effects including impaired wound‐healing, lymphoceles and delayed graft function. As transplant clinicians with experience in the use of sirolimus, we believe such side‐effects can be limited by tailored clinical management. We present recommendations based on published literature and our clinical experience. Furthermore, guidance is provided on sirolimus use during surgery, both at transplantation and for subsequent operations.

show abstract

“…One retrospective study of 142 young kidney transplant recipients (mean age, 29.7 ± 9.43 years, 114 LRRT and 28 DDRT) showed that pretransplant systolic blood pressure <120 mmHg was significantly associated with DGF particularly in LDRT [128].…”

Section: Hypertensionmentioning

confidence: 99%

Living Donation Mitigates Poorer Outcomes in Marginal Recipients

2016

View full text Add to dashboard Cite

Increasing the number of kidney transplantations results in the trend toward the utilization of marginal but acceptable kidneys for deceased donor renal transplantations (DDRT). At the same time, the acceptance of recipients with high medical, surgical, immunological, or psychosocial risks of poor transplant outcomes as we refer to here as "marginal recipients" has been increasing. The combination of both a low quality donor kidney and marginal kidney transplant recipient leads to unfavorable outcomes during the peri-and post-transplant periods. Since some of the risk factors are non-modifiable, living donor renal transplantation (LDRT)with high-quality kidneys and a well-planned operation could potentially mitigate unfavorable outcomes in high risk marginal recipients. In this article, we review common comorbid conditions and risk factors in marginal recipients. We then discuss the different outcomes between DDRT and LDRT in marginal recipients during the perioperative period and suggest potential strategies for utilizing living kidney organs to mitigate the poor outcomes of DDRT.

show abstract

Pretransplantation Systolic Blood Pressure and the Risk of Delayed Graft Function in Young Living-Related Renal Allograft Recipients

Cited by 13 publications

References 12 publications

Association of pre‐transplant blood pressure with post‐transplant outcomes

Association of pre‐transplant blood pressure with post‐transplant outcomes

Practical recommendations for the early use of m-TOR inhibitors (sirolimus) in renal transplantation

Living Donation Mitigates Poorer Outcomes in Marginal Recipients

Contact Info

Product

Resources

About