Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients - identification of patient subsets with increased transplant-related mortality

Metabolomic profiling reveals key metabolites associated with hypertension progression

“…Stearidonate has been found to be altered in many metabolomics studies. For example, metabolomics profiling of patients with excessive fluid retention, inflammation and acute graft vs. host rejection revealed an alteration in stearidonate (18:4n-3) ( 31 ). Exposure to dioxin, which is known to increase the risk of cardiovascular diseases and hypertension, also lead to increased stearidonate in mice liver ( 32 ).…”

“…Consistent with our results, a positive association between hexadecadienoate and systolic and diastolic blood pressure has reported in Chinese adults ( 41 ). Moreover, a study investigating the metabolomic profile in patients with chronic thromboembolic pulmonary hypertension showed higher hexadecadienoate levels in those patients compared to controls ( 31 ). Hexadecadienoate (16:2n6) was also listed among the metabolites differentiating insulin-sensitive from insulin-resistant lean/overweight subjects ( 42 ).…”

Metabolic profile analysis in hematological malignancies

“…These scales, in addition to remaining reliable, validated tools for predicting patient outcomes, might also be helpful in individualized, risk-adapted initial treatment decisions and predicting outcomes for appropriate of treatment response. The final section describes the challenges underlying metabolomics-based experiments and discusses the potential pitfalls of the analytical process, including study design and sample collection (Table I [18,19,[21][22][23][24][25][26][27][28]).…”

“…Findings indicate that metabolites are essential regulators of vascular, renal, endothelial, and gastrointestinal cell function, as well as the function of various immune system cells [53,54]. A recently published study by Reikvam et al [24] indicates the potential role of assessing the metabolite profile before a planned allo-SCT procedure. They compared the serum metabolite profile of patients before myeloablative conditioning according to three transplant-related mortality (TRM) complications: 1) acute graft-versus-host disease (aGvHD); 2) extensive fluid overload (FO); and 3) pretransplant inflammation (pTI).…”

“…Moreover, T-cells express adenosine receptors, and adenosine plays a crucial role in regulating the initial phases of T-cell activation. Furthermore, Reikvam et al [24] identified a group of metabolites most related to the occurrence of these complications. Given the high risk of death during and after bone marrow transplantation, metabolite profile analysis appears to be a promising new tool to facilitate clinical decision-making before the allo-SCT procedure.…”