Pretransplant hepatitis C virus infection and its effect on the post‐transplant course of living renal allograft recipients

Einollahi, Behzad; Hajarizadeh, Behzad; Siamak, Bakhtiari; Lesanpezeshki, M; Khatami, Mohammad Reza; Nourbala, Mohamad Hossein; Pourfarziani, Vahid; Alavian, Seyed Moayed

doi:10.1046/j.1440-1746.2003.03063.x

Cited by 33 publications

(22 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, HCV-infected renal allograft recipients with abnormal liver function had inferior survival rates. Several other studies [131,132,133,134,135], with the exception of one [136], with shorter than 10-year follow-up periods reported no adverse impact of HCV infection on graft and/or patient survival. The promising results of the aforementioned studies suggest that for many patients, the benefits of renal transplantation outweigh its potential risks imposed by immunosuppression.…”

Section: Natural History and Liver Histopathology In Hcv-infected Hd mentioning

confidence: 98%

Hepatitis C in Hemodialysis Patients: Current Global Magnitude, Natural History, Diagnostic Difficulties, and Preventive Measures

2008

Self Cite

View full text Add to dashboard Cite

Hepatitis C virus (HCV) infection is a significant cause of morbidity and mortality in hemodialysis (HD) patients. The reported prevalence of HCV among the HD population has varied greatly from 1.9 to 84.6% in different countries in recent years. The length of time on HD is generally believed to be associated with HCV acquisition in HD subjects. Nevertheless, several recent reports failed to recognize any significant role of blood transfusion. Although there are some considerations about the accuracy of serologic testing in detecting HCV in HD patients, the accumulated data in this review suggest the false-negativity rate to be not more than 1.66% (153/9,220). Therefore, substituting virologic for serologic testing in the routine diagnosis of HCV infection in HD patients seems unreasonable. Several phylogenetic analyzes of viral isolates suggested nosocomial patient-to-patient transmission of HCV among HD patients for which the main potential source is believed to be contaminated hands and articles. However, isolation of HCV-infected HD patients and use of dedicated machines are currently unjustified while strict adherence to universal precautions seems to be enough to control disease spread in HD units. The present article is an update on epidemiological and clinical features of HCV in HD population.

show abstract

Section: Natural History and Liver Histopathology In Hcv-infected Hd mentioning

confidence: 98%

Hepatitis C in Hemodialysis Patients: Current Global Magnitude, Natural History, Diagnostic Difficulties, and Preventive Measures

2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…3, 4). It was reported by Einollahi et al 29 that the 7-year patient survival rate was 89.9% in their HCV-positive group vs 95.5% in their HCVnegative group (P = 0.74), while the 7-year graft survivals were 82.0% and 75.0%, respectively (P = 0.39). They concluded that HCV infection did not seem to infl uence patient or graft survival within a medium-time follow up in living allograft recipients, and anti-HCV-antibody-positive status alone was not a contraindication for renal transplantation.…”

Section: Discussionmentioning

confidence: 82%

Hepatic dysfunction in kidney transplant recipients: prevalence and impact on graft and patient survival

et al. 2007

View full text Add to dashboard Cite

Viral infections-especially HCV and CMV-were more prevalent in the group of patients with persistent hepatic dysfunction, with duration of dialysis as an important risk factor for HCV infection. Dose-dependent cyclosporine-induced hepatic dysfunction was observed early post-transplant. Neither tacrolimus- nor sirolimus-associated hepatic dysfunction was dose-dependent. Hepatic dysfunction had no significant impact on either patient or graft survival; however, this finding may be due to the relatively short duration of follow up.

show abstract

“…A multivariate analysis showed similar seven-year patient and graft survival rates in anti-HCV positive and anti-HCV negative RT recipients. 23 In another study, anti-HCV positive RT patients had a better five-year survival than anti-HCV negative patients. 24 In an earlier study we had found HCV infection to be a bad prognostic indicator for patient and graft survival duration in RT recipients and infections were the commonest cause of death in our patients.…”

Section: Discussionmentioning

confidence: 95%

High prevalence of hepatitis C virus-ribonucleic acid positivity in anti-hepatitis C virus negative renal transplant patients

Hooda

Varma

Chopra

et al. 2012

Medical Journal Armed Forces India

View full text Add to dashboard Cite

Pretransplant hepatitis C virus infection and its effect on the post‐transplant course of living renal allograft recipients

Cited by 33 publications

References 24 publications

Hepatitis C in Hemodialysis Patients: Current Global Magnitude, Natural History, Diagnostic Difficulties, and Preventive Measures

Hepatitis C in Hemodialysis Patients: Current Global Magnitude, Natural History, Diagnostic Difficulties, and Preventive Measures

Hepatic dysfunction in kidney transplant recipients: prevalence and impact on graft and patient survival

High prevalence of hepatitis C virus-ribonucleic acid positivity in anti-hepatitis C virus negative renal transplant patients

Contact Info

Product

Resources

About