Pretransplant dyslipidaemia influences primary graft dysfunction after lung transplantation

Cottini, Silvia R; Ehlers, Ulrike; Pagnamenta, Alberto; Brandi, Giovanna; Weder, Walter; Schuepbach, Reto A.; Béchir, Markus; Benden, Christian

doi:10.1093/icvts/ivv295

Cited by 8 publications

(16 citation statements)

References 19 publications

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“…The main findings of our study are that PH is not associated with the development of PGD3 after LTX in our single‐center patient cohort; in our cohort, only low HDL‐C was identified as a risk factor for PGD3. As such, these data are along the line of findings we previously reported …”

Section: Discussionsupporting

confidence: 91%

“…Second, the study confirmed our previous findings showing that HDL‐C levels are inversely associated with the development of PGD3 with higher levels of HDL‐C showing less PGD3 and vice versa.…”

Section: Discussionmentioning

confidence: 99%

“…The PaO2/FiO2 ratio was measured serially each day. Risk factors previously identified in the literature were investigated, including high‐density lipoprotein‐cholesterol (HDL‐C), which has been previously shown to be a potential protective factor for the development of PGD3 by our group …”

Section: Methodsmentioning

confidence: 99%

“…Risk factors previously identified in the literature were investigated, including high-density lipoprotein-cholesterol (HDL-C), which has been previously shown to be a potential protective factor for the development of PGD3 by our group. 14 The immunosuppression regimen consisted of induction therapy with basiliximab and triple maintenance immunosuppression with steroids, cyclosporine A, and azathioprine or mycophenolate mofetil, as previously described. 15 Data are presented as arithmetic mean and standard deviation (SD), median and interquartile range (IQR) or absolute numbers with percentages, as appropriate.…”

Section: All Adult Ltx Candidates Evaluated and Listed For Ltx Betweenmentioning

confidence: 99%

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Pulmonary hypertension is not a risk factor for grade 3 primary graft dysfunction after lung transplantation

Cottini

Brandi

Pagnamenta

et al. 2018

Clinical Transplantation

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Grade 3 primary graft dysfunction (PGD3) represents the most important risk factor for patient mortality during the first year after lung transplantation (LTX). We investigated whether pretransplant pulmonary hypertension (PH) is a risk factor for the development of PGD3. This retrospective, single-center cohort study included 96 candidates undergoing right heart catheterization (RHC) prior to being listed for LTX between March 2000 and October 2015. Based on their mean pulmonary artery pressure (mPAP) levels, the patients were classified into 3 groups: (1) <25 mm Hg, (2) 25-34 mm Hg and (3) ≥35 mm Hg. Forty-seven patients were classified in group 1, 31 in group 2, and 18 in group 3. Fifteen recipients (16%, 95%-CI 8-23) developed PGD3. In the univariate analysis, the diagnosis of interstitial lung disease (ILD) compared to COPD (OR: 7.06, P = .005), blood transfusion >1000 mL during surgery (OR: 5.25, P = .005), the need for intra-operative cardio-pulmonary bypass (CPB) or extra-corporeal membrane oxygenation (ECMO) (OR: 4, P = .027), mPAP (OR 1.06, P = .007) and serum high density lipoprotein-cholesterol (HDL-C) (OR 0.09, P = .005) were associated with PGD3. In the multivariable logistic regression analysis, only HDL-C (OR 0.10, P = .016) was associated with PGD3 based on our single-center cohort data analysis.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: All Adult Ltx Candidates Evaluated and Listed For Ltx Betweenmentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary hypertension is not a risk factor for grade 3 primary graft dysfunction after lung transplantation

Cottini

Brandi

Pagnamenta

et al. 2018

Clinical Transplantation

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“…Several studies have found an association between recipient increased body mass index and increased risk of PGD. Most of them have been analyzed in two successive systematic reviews and meta‐analyses ; others have been described more recently . Moreover, Shah et al .…”

Section: Discussionmentioning

confidence: 99%

Inhaled nitric oxide dependency at the end of double-lung transplantation: a boosted propensity score cohort analysis

et al. 2018

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Summary Inhaled nitric oxide (iNO) is usually used during lung transplantation despite controversial postoperative benefits. Our group chose to administer iNO systematically during the procedure and stop at the end of surgery. This study aims to describe the features of patients who cannot be weaned from iNO, the reasons for this and its impact on postoperative outcomes. This is a monocentric cohort study comprised all consecutive patients who underwent double‐lung transplantation (DLT) between 1 January 2012 and 1 January 2016. The impact of iNO dependency on postoperative outcomes was estimated using a boosted inverse probability of treatment weighting estimator. A total of 9.8% of the 173 patients included in the study could not be weaned from iNO at end‐surgery stage. Body mass index (OR = 2.03, 95% CI = 1.14–3.29, P = 0.02) and intraoperative extracorporeal membrane oxygenation (OR = 1.80, 95% CI = 1.02–2.72, P = 0.04) were risk factors for iNO dependency In the weighted population, iNO dependency was associated with an increased prevalence of grade 3 primary graft dysfunction (adjusted RR = 4.20, 95% CI = 1.75–10.09, P < 0.001) and decreased postoperative survival during the first 1500 days of follow‐up (adjusted HR = 5.0, 95% CI = 1.86–13.48, P < 0.001). Inhaled nitric oxide dependency is an early marker of a poor prognosis following DLT.

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Impact of pre‐lung transplant statin use on the development of primary graft dysfunction

et al. 2023

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Primary graft dysfunction (PGD) is an acute lung injury occurring within 72 h of lung transplantation. The International Society for Heart and Lung Transplantation (ISHLT) defines diagnostic criteria, which consists of the presence of pulmonary infiltrates on imaging and the ratio of arterial oxygen partial pressure (PaO 2 ) to fractional inspired oxygen (FiO 2 ), or the P/F ratio. The P/F ratio is evaluated at

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Pretransplant dyslipidaemia influences primary graft dysfunction after lung transplantation

Cited by 8 publications

References 19 publications

Pulmonary hypertension is not a risk factor for grade 3 primary graft dysfunction after lung transplantation

Pulmonary hypertension is not a risk factor for grade 3 primary graft dysfunction after lung transplantation

Inhaled nitric oxide dependency at the end of double-lung transplantation: a boosted propensity score cohort analysis

Impact of pre‐lung transplant statin use on the development of primary graft dysfunction

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