2014
DOI: 10.7860/jcdr/2014/6581.4415
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Pretibial Myxedema Associated with Euthyroid Hashimoto’s Thyroiditis: A Case Report

Abstract: A 63-year-old woman presented with a six month history of a large pruritic plaque which was present over both her legs and feet. The lesions had first appeared over her right leg, followed by involvement of left leg. She denied fatigue, heat intolerance, hand tremor, constipation, unexplained weight gain or change in voice. Her past medical history included Type-2 diabetes mellitus, which was currently diet controlled and hypertension, of two year's duration. Her current medications included an angiotensin rec… Show more

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Cited by 7 publications
(11 citation statements)
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“…Even if PTM simultaneously appeared in thyroid dysfunction such as hyperthyroidism or hypothyroidism, PTM would not relieve after correcting the thyroid dysfunction in our investigation. However, the onset of PTM in euthyroid patients has been reported in six cases [14][15][16]. In our investigation, two PTM cases occurred in the euthyroid state before the appearance of hyperthyroidism of Graves' disease.…”
Section: Discussionmentioning
confidence: 47%
“…Even if PTM simultaneously appeared in thyroid dysfunction such as hyperthyroidism or hypothyroidism, PTM would not relieve after correcting the thyroid dysfunction in our investigation. However, the onset of PTM in euthyroid patients has been reported in six cases [14][15][16]. In our investigation, two PTM cases occurred in the euthyroid state before the appearance of hyperthyroidism of Graves' disease.…”
Section: Discussionmentioning
confidence: 47%
“…To the best of our knowledge, PM in euthyroid patients has also been reported in another six cases in the literature [3,[5][6][7][8][9]. The absence of the commonly assessed thyroid autoantibodies (TPO-Ab, Tg-Ab, TSI, TBII) was evident in two of them [5,6] and positive thyroid autoantibodies (either TSI or TPO-Ab, Tg-Ab,) in another two [3,7], while in two other cases, there were no available data regarding thyroid autoantibody tests [8,9]. There is no plausible explanation for this rare manifestation of PM in our patient.…”
Section: Discussionmentioning
confidence: 65%
“…Histopathology usually shows deposition of mucin/ glycosaminoglycan among the dermal collagen fibers in the dermis, along with lymphocytic infiltration in most cases, without affecting the epidermis [2,4]. The differential diagnosis includes simple edema as a result of fluid retention or venus insufficiency, chronic lichenified dermatitis, hypertrophic lichen planus, urticarial phase of bullous pemphigoid or, rarely, papular, follicular, or reticular erythematous mucinosis [2,3].…”
Section: Discussionmentioning
confidence: 99%
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“…As to outcome of PTM, generally accepted view was that it was self-limited and lesions usually resolved spontaneously without requirement of therapy [ 7 , 8 ]. This view was contradicted to the clinical reality.…”
Section: Discussionmentioning
confidence: 99%