Pretibial Lymphoplasmacytic Plaque in Children

Fried, Isabella; Wiesner, Thomas; Cerroni, Lorenzo

doi:10.1001/archdermatol.2009.341

Cited by 24 publications

(36 citation statements)

References 5 publications

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“…In some but not all of the biopsies described in the case of Fried et al [2], this infiltrate also contained some small, well-circumscribed epithelioid granulomas without necrosis. This was also observed in our case [3] in 1 of the 3 biopsies which showed additional new histopathological features such as a lichenoid reaction with vacuolization of the basal cell layer combined with numerous apoptotic bodies and lymphoid exocytosis and striking vascular hyperplasia consisting of thick-walled vertically arranged capillaries in the upper dermis [3].…”

Section: Discussionmentioning

confidence: 98%

“…The second child presented with a cluster of linearly arranged dark reddish brown papulonodules surrounded by a white halo on the right anterior leg. Fried et al [2] then reported a case in an 11-year-old girl with a 5-year history of a reddish brown irregular plaque 40 × 25 mm in diameter on the left anterior tibia with strikingly similar clinical and histopathological features. These authors believed that there was not enough evidence to prove that it was a localized form of cutaneous plasmacytosis and that the former term could be misleading, so they chose the term ‘pretibial lymphoplasmacytic plaque’.…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemistry showed a mixture of T-cell and B-cell lymphocytes with numerous plasma cells. Special immunoperoxidase studies in paraffin sections for immunoglobulin light chain showed a polyclonal process in 4 cases/4 [1,2,4]. Immunoglobulin chain rearrangement showed a polyclonal process in 2 cases/2 and monoclonality in 1 case [5].…”

Section: Discussionmentioning

confidence: 99%

“…The lesion recurred and then stabilized without any treatment [2,3]. In 2 patients, the lesion was surgically removed without recurrence [4,5].…”

Section: Discussionmentioning

confidence: 99%

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Tibial Lymphoplasmacytic Plaque: A New, Illustrative Case of a Recently and Poorly Recognized Benign Lesion in Children

Moulonguet¹,

Hadj‐Rabia²,

Gounod

et al. 2012

Dermatology

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Tibial lymphoplasmacytic plaque (TLP) is a recently recognized clinicopathological entity affecting children and is characterized by a linear, reddish brown plaque on the leg with a dense dermal lymphoplasmacytic infiltrate. No effective treatments are available for this lesion of unknown etiology and its course is chronic. We report a new case in which, for the first time, a causative factor (insect bite) is strongly suspected. The clinical and pathological features of TLP may be misleading for the uninformed dermatologist or pathologist. Therefore, we would like to draw attention to this very distinctive clinicopathological presentation in order to help them recognize it easily and prevent it from being misdiagnosed as an infectious disease or, above all, a cutaneous lymphoma. We will discuss the relationship between TLP and linear acral pseudolymphomatous angiokeratoma of children, a variant of pseudolymphoma localized on acral sites in children which may share some of TLP’s histopathological features.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The lesion recurred and then stabilized without any treatment [2,3]. In 2 patients, the lesion was surgically removed without recurrence [4,5].…”

Section: Discussionmentioning

confidence: 99%

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Tibial Lymphoplasmacytic Plaque: A New, Illustrative Case of a Recently and Poorly Recognized Benign Lesion in Children

Moulonguet¹,

Hadj‐Rabia²,

Gounod

et al. 2012

Dermatology

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“…1,2 Three cases of reactive lymphocytic and plasma cell cutaneous infiltrate with very distinctive clinical and histopathological features have recently been reported in children. 3,4 We describe here a new and characteristic case with, in addition, some novel histological findings.…”

Section: Introductionmentioning

confidence: 85%

A Pretibial Plaque in a Five and a Half year–Old Girl

Moulonguet¹,

Gantzer²,

Bourdon-Lanoy³

et al. 2012

The American Journal of Dermatopathology

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A five and a half year-old girl presented with a reddish-brown plaque on her right anterior tibia, first observed 1 year previously and without any history of injury or insect bite. Histological examination showed a dense dermal infiltrate composed of plasma cells and small lymphocytes, combined with lymphocytic exocytosis in the epidermis and interface dermatitis. In addition, a second biopsy found small epithelioid granulomas within the lymphoplasmocytic infiltrate. Infection was ruled out. No clonality was found. None of the treatments attempted was successful (antibiotics and steroids), and the lesion was stable but did not improve for 4 years. The same features typical of lymphoplasmocytic pseudolymphoma were observed on a third biopsy. A diagnosis of "pretibial lymphoplasmocytic plaque" was made on the basis of clinical and histological findings. Recently, 3 other cases of this type of lymphocytic and plasma cell cutaneous infiltrate with very distinctive clinical and histopathological features have been reported in children. Our case is instructive because it presents new and as yet undocumented histopathologic features including a lichenoid reaction with vacuolization of the basal cell layer and numerous apoptotic bodies, apparent in 2 of the 3 biopsies, and hypervascularity with thick-walled blood vessels lined with plump endothelial cells in the upper dermis. The clinicopathological presentation of these cases, including ours, is homogenous suggesting a specific entity described as "pretibial lymphoplasmocytic plaque in children". This seems to be a benign, chronic, reactive process, probably arising secondary to a local response to an unknown antigen.

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Pseudolymphomas of the Skin

2014

Skin Lymphoma

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Pretibial Lymphoplasmacytic Plaque in Children

Cited by 24 publications

References 5 publications

Tibial Lymphoplasmacytic Plaque: A New, Illustrative Case of a Recently and Poorly Recognized Benign Lesion in Children

Tibial Lymphoplasmacytic Plaque: A New, Illustrative Case of a Recently and Poorly Recognized Benign Lesion in Children

A Pretibial Plaque in a Five and a Half year–Old Girl

Pseudolymphomas of the Skin

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