Pretherapeutic Plasma Pro- and Anti- Inflammatory Mediators Are Related to High Risk of Oral Mucositis in Pediatric Patients with Acute Leukemia: A Prospective Cohort Study

Ye, Ying; Carlsson, Göran; Agholme, Monica Barr; Karlsson-Sjöberg, Jenny M. T.; Yucel‐Lindberg, Tülay; Pütsep, Katrin; Modéer, Thomas

doi:10.1371/journal.pone.0064918

Cited by 28 publications

(44 citation statements)

References 24 publications

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“…Other authors [25] have observed mucositis percentages higher than those found in this study. The results of research conducted in São Luis (Brazil) [17] were different than those of this study, as few cases of mucositis occurred during anticancer treatment for leukaemia. This finding was likely due to the small sample, which included only 12 individuals.…”

Section: Discussioncontrasting

confidence: 93%

“…Many national and international studies in the literature show a correlation between anticancer treatments, particularly chemotherapy and the occurrence of oral complications in infant-juvenile patients and adults [7, 10, 17–26], and the magnitude of these side effects depends on a number of factors related to the treatment, tumour and patient [22]. …”

Section: Discussionmentioning

confidence: 99%

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Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy

2017

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BackgroundOral complications may be observed during chemotherapy and are important side effects that may directly affect the anticancer treatment, even causing septicaemia in some cases. This research was done in order to evaluate changes in oral lesions during follow-up of children and adolescents in chemotherapy at Hospital Estadual Infantil Nossa Senhora da Glória (HEINSG).MethodsThe study design was longitudinal, 45 patients were evaluated and monitored for 1 month after the initiation of chemotherapy. Twenty-eight patients were male and 17 female, ranging from 3 months to 18 years old.ResultsThe results show an increase in the number of mucositis cases and a decrease in xerostomia cases after the initiation of treatment, and other oral lesions were also found in low numbers.ConclusionsIt is possible to avoid oral complications by maintaining a good oral health, and reducing infectious outbreaks. It is also feasible to obtain an early diagnosis of, and treat these oral complications, preventing them from following a more severe clinical course that may negatively affect the individual’s treatment. This outcome requires the presence of a dental surgeon on the multidisciplinary cancer treatment team.

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Section: Discussioncontrasting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy

2017

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“…Studies have shown that the incidence of oral mucositis differs according to the type of cancer and treatment regimen, suggesting that it is more frequent in those with hematological malignancies compared with patients suffering solid tumors [10][11][12][13]. Based on the occurrence of oral mucositis is different in these groups of tumors [10], in the present study, the patients were divided into two groups-hematologic malignancies and solid tumors.…”

Section: Discussionmentioning

confidence: 78%

“…Neutropenia and lymphopenia are common findings among patients with hematologic malignancies and might also develop as an adverse effect of treatment [11,16]. According to one study, a reduction in neutrophils count can result in inefficient protection against damage to the oral mucosa and can impair epithelial cell proliferation [17].…”

Section: Discussionmentioning

confidence: 99%

Severe Oral Mucositis in Pediatric Cancer Patients: Survival Analysis and Predictive Factors

Damascena

Lucena

Ribeiro

et al. 2020

IJERPH

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This paper investigates the occurrence of severe oral mucositis and associated factors in blood and solid cancer pediatric patients subjected to cancer treatment, using a survival analysis. A longitudinal, descriptive, observational and inductive study of 142 pediatric patients aged from 0 to 19 years was conducted from 2013 to 2017. Data were collected using a form to record the sociodemographic characteristics and health-related aspects of patients and the modified Oral Assessment Guide (OAG). Survival analysis was performed using the Kaplan–Meier method and Cox semiparametric model. The median times to occurrence of severe oral mucositis were 35.3 and 77.1 days for patients with hematologic malignancies and solid tumors, respectively. The Cox model showed that white cell changes and platelet counts as well as the use of natural chemotherapeutic agents are risk factors for the occurrence of oral mucositis among patients with hematologic malignancies. Nonetheless, among patients with solid tumors, the occurrence of oral mucositis was associated with female sex, mixed ethnicity, the presence of metastasis, abnormal creatinine levels, a combination of chemotherapy, radiotherapy, and surgery, and the administration of chemotherapeutic agents included in the miscellaneous group. The time to occurrence of severe oral mucositis and its associated factors varied according to cancer type.

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“…Interestingly, a recent study reported that, at the time of diagnosis of acute leukemia, high prechemotherapy plasma levels of both pro- and anti-inflammatory cytokines and low levels of an antimicrobial protein pro-LL-37 were associated with the highest OM risk, suggesting that a proinflammatory state preceding high-dose chemotherapy may predispose to complications [196]. …”

Section: Discussion and Suggestions For Future Researchmentioning

confidence: 99%

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Haverman

Raber-Durlacher

Rademacher

et al. 2014

Mediators of Inflammation

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Hematopoietic stem cell transplantation (HSCT) is widely used as a potentially curative treatment for patients with various hematological malignancies, bone marrow failure syndromes, and congenital immune deficiencies. The prevalence of oral complications in both autologous and allogeneic HSCT recipients remains high, despite advances in transplant medicine and in supportive care. Frequently encountered oral complications include mucositis, infections, oral dryness, taste changes, and graft versus host disease in allogeneic HSCT. Oral complications are associated with substantial morbidity and in some cases with increased mortality and may significantly affect quality of life, even many years after HSCT. Inflammatory processes are key in the pathobiology of most oral complications in HSCT recipients. This review article will discuss frequently encountered oral complications associated with HSCT focusing on the inflammatory pathways and inflammatory mediators involved in their pathogenesis.

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Pretherapeutic Plasma Pro- and Anti- Inflammatory Mediators Are Related to High Risk of Oral Mucositis in Pediatric Patients with Acute Leukemia: A Prospective Cohort Study

Cited by 28 publications

References 24 publications

Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy

Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy

Severe Oral Mucositis in Pediatric Cancer Patients: Survival Analysis and Predictive Factors

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

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