Preterm Prelabor Rupture of Membranes Linked to Vaginal Bacteriome of Pregnant Females in the Early Second Trimester: a Case-Cohort Design

Mu, Yutong; Hu, Anqun; Kan, Hui; Li, Yijie; He, Yining; Fan, Wei; Liu, Haiyan; Li, Qing; Ying, Zheng

doi:10.1007/s43032-022-01153-0

Cited by 2 publications

(2 citation statements)

References 69 publications

(67 reference statements)

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“…A recent study found that the presence of Lactobacillus mulieris, a new species of Lactobacillus discovered in 2020, was associated with a lower risk of PPROM. Typical pathogens such as Megasphaera, Faecalibacterium and Bifidobacterium were also observed in patients with PPROM [64]. The aforementioned studies in various countries based on different populations have made similar findings.…”

Section: Vaginal Microbiota and Premature Rupture Of Membranesmentioning

confidence: 52%

Advances in Research on the Relationship between Vaginal Microbiota and Adverse Pregnancy Outcomes and Gynecological Diseases

Zhao

Ying

2023

Microorganisms

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The human microbiota inhabiting different parts of the body has been shown to have a significant impact on human health, with the gut microbiota being the most extensively studied in relation to disease. However, the vaginal microbiota is also an essential commensal microbiota in the female body that plays a crucial role in female health. Despite receiving less attention than gut microbiota, its importance in regulating reproductive immunity and its complex dynamic properties have been increasingly recognized in recent years. Advances in research on the relationship between vaginal microbiota and pregnancy outcomes & gynecological diseases in women have shed light on the importance of maintaining a healthy vaginal microbiota. In this review, we aim to compile recent developments in the study of the vaginal microbial ecosystem and its role in female health and reproductive outcomes. We provide a comprehensive account of the normal vaginal microbiota, the association between the vaginal microbiota and pregnancy outcomes, and the impact of the vaginal microbiota on gynecological diseases in women. By reviewing recent research, we hope to contribute to the advancement of academic medicine’s understanding of the vaginal microbiota’s importance in female health. We also aim to raise awareness among healthcare professionals and the general public of the significance of maintaining a healthy vaginal microbiota for better reproductive health and the prevention of gynecological diseases.

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Section: Vaginal Microbiota and Premature Rupture Of Membranesmentioning

confidence: 52%

Advances in Research on the Relationship between Vaginal Microbiota and Adverse Pregnancy Outcomes and Gynecological Diseases

Zhao

Ying

2023

Microorganisms

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“…It has not been clarified whether the markers of inflammation in the cervical fluid are related to those in the intrauterine environment or merely represent a feature of the overall hyperresponsiveness to specific infectious agents. However, it is undeniable that these factors that influence the variation of the microbial-host interaction play an important role in individual sensitivity and adverse pregnancy outcomes ( 25 - 30 ).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Gut Microbiome in Neonates Born by Caesarean Section and Vaginal Seeding with Gut Microbiomes of Neonates Born by Caesarean Section Without Vaginal Seeding and Neonates Born by Vaginal Delivery

Anthoulaki,

Oikonomou,

Papanikolopoulou

et al. 2023

Mater Sociomed

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Background: Pregnancy is an admirable biological process, resulting in significant changes in many of the body's normal systems so that they can support the development of the fetus. These changes involve hormonal changes, weight gain, immune system regulation, and others that need to be synchronized to maintain both maternal and fetal health. Objective: The purpose of this study was to compare gut microbiome in neonates born by caesarean section and vaginal seeding with gut microbiomes of neonates born by caesarean section without vaginal seeding and neonates born by vaginal delivery. Methods: In Democritus University of Thrace, from 2019 to 2022, gut microbiomes were compared for three groups of neonates. Group A included 110 neonates born by CS who underwent vaginal seeding, group B included 85 neonates born by CS without vaginal seeding and group C included 95 neonates born by vaginal delivery. Results: Vaginal seeding in neonates born with CS resulted in gut microbiome which was similar to the gut microbiome of neonates born by vaginal delivery (including lactobacillus species and bacteroides). On the contrary, gut microbiome of neonates born by CS without vaginal seeding was “limited”. Conclusion: According to our findings, vaginal seeding alters the gut microbiome of the neonates born with CS. However, there is a need for further investigation to prove its efficacy and its safety for the neonate.

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Preterm Prelabor Rupture of Membranes Linked to Vaginal Bacteriome of Pregnant Females in the Early Second Trimester: a Case-Cohort Design

Cited by 2 publications

References 69 publications

Advances in Research on the Relationship between Vaginal Microbiota and Adverse Pregnancy Outcomes and Gynecological Diseases

Advances in Research on the Relationship between Vaginal Microbiota and Adverse Pregnancy Outcomes and Gynecological Diseases

Comparison of Gut Microbiome in Neonates Born by Caesarean Section and Vaginal Seeding with Gut Microbiomes of Neonates Born by Caesarean Section Without Vaginal Seeding and Neonates Born by Vaginal Delivery

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