Preterm Glycosuria – New Data from a Continuous Glucose Monitoring System

Jagła, Mateusz; Szymońska, Izabela; Starzec, Katarzyna; Kwinta, Przemko

doi:10.1159/000487846

Cited by 10 publications

(3 citation statements)

References 13 publications

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“…For glucose measurements, a continuous glucose monitoring system (CGM) was used, as previously described. 5 Both the accuracy and safety of the CGM system were previously validated. 6 The CGM system was calibrated at least three times a day using blood samples obtained from radial or umbilical arterial lines and infused with saline solution alone.…”

Section: Continuous Glucose Monitoringmentioning

confidence: 99%

Glycemic Variability Is Associated With Treatment Requiring Retinopathy of Prematurity

Jagła¹,

Szymońska²,

Starzec³

et al. 2021

Retina

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Purpose: To assess the association between glycemic variability (GV) and Type 1 retinopathy of prematurity (ROP) in infants with birth weights of less than 1,251 g. Methods: A case–control study of infants with birth weights of less than 1,251 g who developed Type 1 ROP (n = 20) was conducted. Controls had a less severe ROP or no eye disease and were individually matched for gestational age and birth weight (n = 40). Odds ratios of ROP were calculated based on multiple factors including oxygen exposure, respiratory support, incidence of hyperglycemia, and GV. For glucose measurements, a continuous glucose monitoring system was used. Results: There were no significant differences in gender, antenatal steroid administration, severity of illness, and Apgar score. Univariate analyses suggest increased risk for the development of Type 1 ROP based on incidence of intraventricular hemorrhage Grade 3 or 4 (P = 0.048), duration of oxygen exposure (P = 0.003), incidence of hyperglycemia over 150 mg/dL (P = 0.01), and GV according to significantly higher SD (P = 0.002), coefficient of variation (P = 0.001), and mean amplitude of glucose excursion (P = 0.008). Using a multiple regression model, increased risk of Type 1 ROP was only found to be associated with duration of oxygen exposure and higher GV. Conclusion: Our study demonstrates a relationship between GV and the development of severe ROP.

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Section: Continuous Glucose Monitoringmentioning

confidence: 99%

Glycemic Variability Is Associated With Treatment Requiring Retinopathy of Prematurity

Jagła¹,

Szymońska²,

Starzec³

et al. 2021

Retina

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“…Second, we did not perform urine glucose routinely. However, glycosuria is not a reliable biomarker for assessing blood glucose levels [ 38 , 39 ]. Another limitation is that the group of preterm infants with birth weight < 1500 g or gestational age < 30 weeks as the main target of PN in preterm infants has a small portion in this study.…”

Section: Discussionmentioning

confidence: 99%

The glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study

et al. 2021

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Background Most preterm infants require a continuous glucose infusion in the early postnatal period due to the interruption of the transplacental glucose supply after birth to promote better neurodevelopmental outcomes. Aims To investigate the glucose infusion rate (GIR) on parenteral nutrition (PN) in the first week of life administered in preterm infants and its effect on neonatal morbidity and mortality. Methods This study included 97 infants aged < 37 gestational weeks and weighed < 2500 g at birth. Infants recruited in this study were classified into 3 groups based on the GIR usage in parenteral nutrition as follows: GIR usage of 5- < 7 g/kg/day (Group I), GIR usage of 7–13 g/kg/day (Group II), and GIR usage of > 13–15 g/kg/day (Group III). Univariate and multivariate logistic regression analyzes were carried out to investigate whether the GIR usage in the three groups was associated with selected neonatal morbidities and mortality. Neonatal morbidities analyzed included respiratory distress syndrome (RDS), necrotizing enterocolitis, sepsis, retinopathy of prematurity, pulmonary hypertension, hypoglycemia, and hyperglycemia. Result Of 97 preterm infants included, 51.5% infants had a gestational age of 34- < 37 weeks, and 54.6% infants had a birth weight of 1500- < 2500 g. The multivariate logistic regression analysis showed that the GIR usage of 5- < 7 g/kg/day was an independent variable that significantly increased the risk of hypoglycemia (Adjusted Odds Ratio [AOR] = 4.000, 95% Confidence Interval [CI] = 1.384–11.565, P = 0.010) and reduced the risk of sepsis (AOR = 0.096, 95% CI = 0.012–0.757, P = 0.026). The GIR usage in all three groups did not increase the risk of mortality. For neonatal morbidity analyzed in this study, RDS (AOR = 5.404, 95%CI = 1.421–20.548, P = 0.013) was an independent risk factor of mortality. Conclusion The GIR usage of < 7 g/kg/day in PN in the first week of life administered to preterm infants was an independent variable in increasing hypoglycemia, but in contrast, reducing the risk of sepsis.

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“…Jagła et al conducted a study of continuous glucose measurement in interstitial fluid with electrodes and correlated it with glucosuria output. They concluded that the renal glucose threshold is between 8.3 mmol/L and 10.0 mmol/L [9].…”

Section: Introductionmentioning

confidence: 99%

A Higher Amount of Nutritional Intake as a Possible Cause of Hyperglycemia in Extremely Premature Infants in Parenteral and Enteral Nutrition at the Tertiary Neonatal Intensive Care Unit

Predanič Drobne,

Kornhauser Cerar,

Erčulj

et al. 2023

Children

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Background: This study aimed to find an association between infants who had hyperglycemia and those who did not, those treated with insulin or not and several prenatal and postnatal variables or the suboptimal prescription of parenteral nutrition. Methods: We conducted a retrospective study, which included extremely premature infants (<28 weeks of gestation) admitted to the tertiary NICU, University Medical Centre Ljubljana, between 1 January 2021 and 31 December 2021. Blood glucose measurements, insulin treatment, general characteristics, nutritional data and complications of prematurity were obtained retrospectively from hospital data. RESULTS: There were 21 infants included in the study who did not receive insulin and 17 who were treated with insulin. Infants receiving insulin were younger and lighter compared to the non-insulin treatment group (mean gestational age 178 vs. 188 days; median birth weight 680 g vs. 990 g). The younger insulin group of infants received the same daily number of total macronutrients per kg per day compared to the older non-insulin group, i.e., glucose, lipids and amino acids, as recommended for the gestational age and birth weight. After adjusting for gestational age, no significant association with complications of prematurity was found. Conclusions: The postulated explanation (with the prescription of a higher amount of macronutrients during the first seven days) for hyperglycemia and treatment with insulin in the less mature and lighter infants cannot be supported by the data given.

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Preterm Glycosuria – New Data from a Continuous Glucose Monitoring System

Cited by 10 publications

References 13 publications

Glycemic Variability Is Associated With Treatment Requiring Retinopathy of Prematurity

Glycemic Variability Is Associated With Treatment Requiring Retinopathy of Prematurity

The glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study

A Higher Amount of Nutritional Intake as a Possible Cause of Hyperglycemia in Extremely Premature Infants in Parenteral and Enteral Nutrition at the Tertiary Neonatal Intensive Care Unit

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