Preterm fetal growth restriction is associated with increased parathyroid hormone–related protein expression in the fetal membranes

Curtis, Narelle E; King, Roger G; Moseley, Jane M.; Ho, Patricia W. M.; Rice, Gregory E.; Wlodek, Mary E.

doi:10.1067/mob.2000.106593

Cited by 17 publications

(11 citation statements)

References 26 publications

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“…Emerging evidence supports roles for N‐terminal and mid‐region peptide effects on the placenta. Putative functions of PTHrP during pregnancy include uterine smooth muscle relaxation and vasodilatation (Curtis et al ., 2000; Macgill et al ., 1997), regulation of placental calcium transfer (Kovacs & Kronenberg, 1997), and normal foetal development. N‐terminal forms of PTHrP inhibit acetylcholine‐induced uterine contractions in the rat (Barri et al ., 1992).…”

Section: Physiological Role Of Pthrp In Placenta and Interaction Withmentioning

confidence: 99%

“…Levels of PTHrP decreased acutely in the amnion and myometrium at the time of onset of labour in humans (Ferguson et al ., 1992) suggesting that N‐terminal PTHrP may have a role in regulating the onset of labour. Contradictory evidence failed to disclose a change in the expression of PTHrP mRNA or protein with term labour or rupture of the foetal membranes in humans (Curtis et al ., 2000). Rather, upregulation of mRNA and protein in foetal membranes at term suggests an important role in late pregnancy.…”

Section: Physiological Role Of Pthrp In Placenta and Interaction Withmentioning

confidence: 99%

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Parathyroid hormone‐related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets

Clemens

Cormier

Eichinger

et al. 2001

British J Pharmacology

179

124

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The cloning of the so-called`parathyroid hormone-related protein' (PTHrP) in 1987 was the result of a long quest for the factor which, by mimicking the actions of PTH in bone and kidney, is responsible for the hypercalcemic paraneoplastic syndrome, humoral calcemia of malignancy. PTHrP is distinct from PTH in a number of ways. First, PTHrP is the product of a separate gene. Second, with the exception of a short N-terminal region, the structure of PTHrP is not closely related to that of PTH. Third, in contrast to PTH, PTHrP is a paracrine factor expressed throughout the body. Finally, most of the functions of PTHrP have nothing in common with those of PTH. PTHrP is a poly-hormone which comprises a family of distinct peptide hormones arising from post-translational endoproteolytic cleavage of the initial PTHrP translation products. Mature N-terminal, mid-region and C-terminal secretory forms of PTHrP are thus generated, each of them having their own physiologic functions and probably their own receptors. The type 1 PTHrP receptor, binding both PTH(1-34) and PTHrP(1-36), is the only cloned receptor so far. PTHrP is a PTH-like calciotropic hormone, a myorelaxant, a growth factor and a developmental regulatory molecule. The present review reports recent aspects of PTHrP pharmacology and physiology, including: (a) the identi®cation of new peptides and receptors of the PTH/PTHrP system; (b) the recently discovered nuclear functions of PTHrP and the role of PTHrP as an intracrine regulator of cell growth and cell death; (c) the physiological and developmental actions of PTHrP in the cardiovascular and the renal glomerulo-vascular systems; (d) the role of PTHrP as a regulator of pancreatic beta cell growth and functions, and, (e) the interactions of PTHrP and calcium-sensing receptors for the control of the growth of placental trophoblasts. These new advances have contributed to a better understanding of the pathophysiological role of PTHrP, and will help to identify its therapeutic potential in a number of diseases.

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Section: Physiological Role Of Pthrp In Placenta and Interaction Withmentioning

confidence: 99%

Section: Physiological Role Of Pthrp In Placenta and Interaction Withmentioning

confidence: 99%

Parathyroid hormone‐related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets

Clemens

Cormier

Eichinger

et al. 2001

British J Pharmacology

179

124

View full text Add to dashboard Cite

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“…Thus, PTHrP has been shown to have a physiological role in the development of various organs [11], and recent studies indicate that intracrine effects of PTHrP might affect processes such as cell proliferation, apoptosis and angiogenesis in various tissues [11]. Moreover, PTHrP has critical roles in many diverse biological systems, which include transepithelial calcium transfer, smooth muscle relaxation, apoptosis and cell growth [12][13][14].…”

Section: Introductionmentioning

confidence: 97%

Expression of parathyroid hormone-related protein in the partially obstructed and reversed rabbit bladder

et al. 2008

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“…In this respect, it is known that small bioactive fragments, released by fetal membranes, pass into the maternal circulation, where especially the N‐terminal PTHrP may have potent vasodilator actions (15), (25), (33), opposing the effects of vasoconstrictor agents, including angiotensin II (4). As intrauterine production of the latter may be increased in IUGR (34), we speculate that the higher maternal than fetal N‐terminal PTHrP levels in the IUGR group could possibly result from a compensatory increase in the transport of N‐terminal PTHrP to the maternal circulation (34).…”

Section: Discussionmentioning

confidence: 99%

N‐terminal parathyroid hormone‐related protein levels in human intrauterine growth restricted pregnancies

Briana

Boutsikou

Baka

et al. 2007

Acta Obstet Gynecol Scand

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Preterm fetal growth restriction is associated with increased parathyroid hormone–related protein expression in the fetal membranes

Cited by 17 publications

References 26 publications

Parathyroid hormone‐related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets

Parathyroid hormone‐related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets

Expression of parathyroid hormone-related protein in the partially obstructed and reversed rabbit bladder

N‐terminal parathyroid hormone‐related protein levels in human intrauterine growth restricted pregnancies

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