Preterm delivery: a public health perspective

Mattison, Donald R.; Damus, Karla; Fiore, Ellen; Petrini, Joann; Alter, Caroline

doi:10.1046/j.1365-3016.2001.00004.x

Cited by 137 publications

(100 citation statements)

References 28 publications

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“…41 Environmental factors such as infection, cigarette smoking, stress and low socioeconomic status likely add to an individual's baseline genetic risk of PTD. 1,10 In this study, these variables were only inconsistently available, so we have focused initially on genetic factors only.…”

Section: Dhcr24rs2274941mentioning

confidence: 99%

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Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery

et al. 2007

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Objective: To examine the contribution of variants in fetal and maternal cholesterol metabolism genes in preterm delivery (PTD).Study Design: A total of 40 single-nucleotide polymorphisms (SNPs) in 16 genes related to cholesterol metabolism were examined for 414 preterm infants (gestational ages 22 to 36 weeks; comprising 305 singletons and 109 twins) and at least 1 parent. Fetal effects were assessed using the transmission disequilibrium test (TDT) for each SNP, followed by a log linear model-based approach to utilize families with missing parental genotypes for those SNPs showing significance under TDT. Genetic variant effects were examined for a role in PTD, gestational age and birth weight. Maternal effects were estimated using a log linear model-based approach.Result: Among singleton gestations, suggestive association (P<0.01 without adjusting for multiple comparisons) was found between birth weight and fetal DHCR7 gene/SNP combinations (rs1630498, P ¼ 0.002 and rs2002064, P ¼ 0.003). Among all gestations, suggestive associations were found between PTD and fetal HMGCR (rs2303152, P ¼ 0.002) and APOA1 (rs 5070, P ¼ 0.004). The result for HMGCR was further supported by the log linear model-based test in the single births (P ¼ 0.007) and in all births (P ¼ 0.006). New associations (APOE and ABCA1) were observed when birth weight was normalized for gestational age suggesting independent effects of variants on birth weight separate from effects on PTD. Testing for maternally mediated genetic effects has identified suggestive association between ABCA1 (rs4149313, P ¼ 0.004) and decreased gestational age.Conclusion: Variants in maternal and fetal genes for cholesterol metabolism were associated with PTD and decreased birth weight or gestational age in this study. Genetic markers may serve as one mechanism to identify high-risk mothers and fetuses for targeted nutritional treatment and/or prevention of low birth weight or PTD.

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Section: Dhcr24rs2274941mentioning

confidence: 99%

“…1 Morbidities associated with preterm delivery (PTD) contribute to high costs of hospitalization and lead to long-term disability. 2,3 The cause of PTD can be identified in some cases, however the etiology in the majority of spontaneous PTD remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery

et al. 2007

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“…Unfortunately, the causes of preterm delivery are not well understood. Some pathways thought to be important are genetic factors, stress, and inflammatory response and hemorrhage into the myometrium (Mattison, 2001). Within the United States, the preterm delivery rate varies widely by race with African Americans suffering the highest rates and the Asian population experiencing the lowest.…”

Section: The Datamentioning

confidence: 99%

Making Babies Healthier By Providing a Managed Care Option to California's Poor

Barham

Gertler

2003

SSRN Journal

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“…Preterm delivery is more common in the United States than in many other developed countries and is the major factor responsible for the relatively high infant mortality in this country [2].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a high-performance liquid chromatography–mass spectrometric assay for the determination of 17α-hydroxyprogesterone caproate (17-OHPC) in human plasma

Zhang¹,

Mada²,

Mattison³

et al. 2007

Journal of Chromatography B

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A sensitive and specific method for the determination of 17α-hydroxyprogesterone caproate (17-OHPC) in human plasma using high performance liquid chromatography and mass spectrometry has been developed and validated. Plasma samples were processed by a solid phase extraction (SPE) procedure using Oasis HLB extraction cartridge prior to chromatography. Medroxyprogesterone acetate (MPA) was used as the internal standard. Chromatography was performed using Waters C18 Symmetry analytical column, 3.5 μm, 2.1 × 10 mm, using a gradient elusion with a mobile phase consisting of acetonitrile [A] and 5% acetonitrile in water [B], with 0.1% formic acid being added to both [A] and [B], at a flow rate 0.2 ml/min. The retention times of 17-OHPC and MPA were 8.1 and 5.0 min, respectively, with a total run time of 15 min. Analysis was performed on Thermo Electron Finnigan TSQ Quantum Ultra mass spectrometer in a selected reaction monitoring (SRM), positive mode using electron spray ionization (ESI) as an interface. Positive ions were measured using extracted ion chromatogram mode. The extracted ions following SRM transitions monitored were m/z 429.2→313.13 and 429.2→271.1, for 17-OHPC and m/z 385.1→276 for MPA. The extraction recoveries at concentrations of 5, 10 and 50 ng/ml were 97.1, 92.6 and 88.7%, respectively. The assay was linear over the range 0.5 -50 ng/ml for 17-OHPC. The analysis of standard samples for 17-OHPC 0.5, 1, 2.5, 5, 10, 25 and 50 ng/ml Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 16.7, 12.4, 13.7, 1.4, 5.2, 3.7 and 5.3%, respectively (n=6). This method is simple, adaptable to routine application, and allows easy and accurate measurement of 17-OHPC in human plasma. HHS Public Access

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Preterm delivery: a public health perspective

Cited by 137 publications

References 28 publications

Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery

Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery

Making Babies Healthier By Providing a Managed Care Option to California's Poor

Development and validation of a high-performance liquid chromatography–mass spectrometric assay for the determination of 17α-hydroxyprogesterone caproate (17-OHPC) in human plasma

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