Preterm birth rates were slightly lower in Denmark during the first year of the <scp>COVID</scp>‐19 pandemic compared with the previous 4 years

Hansen, Bertel; Cueto, Heidi Ørum; Petersen, J.B.B.; Zachariassen, Gitte; Christensen, Peter O.; Breindahl, Morten; Kesmodel, Ulrik Schiøler; Henriksen, Tine Brink

doi:10.1111/apa.16401

Cited by 12 publications

(20 citation statements)

References 26 publications

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“…If it is accepted that Norway did not experience a reduction in xPTBs 3 , assuming a 10 % proportion of multifetal xPTB pregnancies, then the Danish reduction of singleton xPTBs pregnancies over a three-month period can be estimated to be ~ 40 %. Clearly compatible with the 73 % (95% CI, 14 % - 93 %) reduction in xPTBs found in the Danish National Patient Register based study on all Danish singleton preterm births 1 , and the 56 % and 47 % reductions in xPTBs in March and April 2020 reported in a study based on data from the Danish Newborn Quality Database 5 .…”

Section: Tablesupporting

confidence: 81%

“…Three subsequent studies, which included Danish data, all examined PTB rates without excluding multifetal pregnancies 3-5 . This makes data interpretation difficult, as multifetal pregnancies have a different set of risk factors for PTB, increased risk of adverse outcome, and a shorter expected pregnancy length.…”

Section: Tablementioning

confidence: 99%

“…Studies including twin pregnancies 3-5 will tend to underestimate an effect solely acting on singleton pregnancies. The OR is 0.20 (95% CI, 0.04 – 0.72) for xPTB rates of combined singleton and twin pregnancies (Table 1), higher, albeit not significantly, than the reported OR 0.09 (95% CI, 0.01 – 0.40) (2) for singleton births during the lockdown period.…”

Section: Tablementioning

confidence: 99%

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Preterm birth rates among twins during the Danish COVID-19 lockdown and mitigation period

Hedley

Bækvad‐Hansen

Hedermann

et al. 2022

Preprint

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Denmark's response to the COVID-19 pandemic was to issue guidelines on containment, isolation, and surveillance. Subsequently, Denmark entered a period with variable mitigation measures including closures of schools and workplaces, travel restrictions, and restrictions on public gatherings. A Danish study covering the lockdown period (March 12 – April 14, 2020) as well as a period of mitigation measures (February 27 – September 30, 2020) showed that the reduction in extremely preterm births was not associated with an increase in singleton stillbirth rate. Subsequent studies examining the impacts of COVID-19 mitigation measures on preterm birth have combined singleton with multifetal pregnancies. However, multifetal pregnancies have a different set of risk factors for preterm birth, as well as, increased risk of adverse outcomes, and a shorter expected pregnancy length. We assessed the impact of the Danish lockdown period, or the mitigation period on multifetal births and found no significant difference in the proportion of preterm twin births among all twin births, either within gestational age groups or in total, for either period.

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Section: Tablesupporting

confidence: 81%

Section: Tablementioning

confidence: 99%

Section: Tablementioning

confidence: 99%

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Preterm birth rates among twins during the Danish COVID-19 lockdown and mitigation period

Hedley

Bækvad‐Hansen

Hedermann

et al. 2022

Preprint

Self Cite

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“…Nevertheless, a recent study reported slightly lower preterm birth rates in Denmark during the first year of the COVID‐19 pandemic compared with the previous 4 years. 5 In addition to high body mass index, advanced maternal age and non‐white ethnic origin, evidence suggests that pre‐existing comorbidities and pregnancy‐specific conditions such as preeclampsia and gestational diabetes are risk factors for severe disease. 4 At the same time, COVID‐19 has increased the incidence of preeclampsia and hypertensive disorders of pregnancy, stillbirths, perinatal mortality and Caesarean deliveries, which should only be performed for standard obstetric indications.…”

Section: Impact On Pregnancy and The Placentamentioning

confidence: 99%

Action is needed to tackle the clinical, psychological and socioeconomic impact of perinatal COVID‐19

2022

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The COVID‐19 pandemic has turned perinatal healthcare into a worldwide public health challenge. Although initial data did not demonstrate pregnancy as a more susceptible period to adverse outcomes of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection, an increasing number of reports now certify maternal illness as a high‐risk condition for the development of maternal–fetal complications. Despite the rarity of SARS‐CoV‐2 vertical transmission, severe maternal illness might induce adverse perinatal and neonatal outcomes. Additionally, perinatal COVID‐19 data may raise concerns about long‐term harmful consequences to the offspring in the framework of non‐communicable diseases. The World Health Organisation, as well as scientific literature, consider the protection of the maternal–fetal dyad against COVID‐19 as a critical issue and, therefore, strongly promote and encourage the vaccination of pregnant and lactating women. Furthermore, the pandemic has triggered an unprecedented recession, leading to historic levels of unemployment and deprivation, while health, societal, economic and gender inequities particularly affecting low‐income and middle‐income countries, have increased. This mini‐review provides an updated brief report on historical, clinical, psychological and socioeconomic aspects of the COVID‐19 pandemic based on 10 lectures presented at the 9th Maria‐Delivoria‐Papadopoulos Perinatal Symposium, held virtually on 19 March 2022.

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“…Most attention has been paid to the impact of the pandemic on preterm birth (PTB), but with inconsistent results. Reductions in PTB rates during COVID-19 pandemic compared with before pandemic have been reported in many countries, such as Australia ( 10 – 12 ), the United States ( 13 – 15 ), Israel ( 16 ), the Netherlands ( 17 ), Denmark and Ireland ( 18 – 20 ), while studies in China, Sweden and Spain have not found such changes ( 21 – 23 ). In a recent meta-analysis, PTB was not significantly changed overall but was decreased in high-income countries ( 24 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of COVID-19 pandemic on birth outcomes: A retrospective cohort study in Nanjing, China

Wen

2022

Front. Public Health

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IntroductionThe coronavirus disease 2019 (COVID-19) pandemic have significantly affected health care systems and daily wellbeing. However, the indirect impacts of the pandemic on birth outcomes are not fully understood. We aimed to examine whether the pandemic altered risk of adverse birth outcomes.MethodsThis retrospective cohort study included all singleton births during 2016–2020 identified in Women's Hospital of Nanjing Medical University. We compared birth outcomes during COVID-19 pandemic (January–December 2020) with before the pandemic (January–December 2016–2019) using Logstic regression adjusted for confounders.ResultsA total of 19,792 and 92,750 births occurred during and before the pandemic, respectively. Maternal characteristics were similar between groups, except maternal age was higher in pandemic cohort. We observed a reduction in preterm birth (PTB, <37 weeks) during the pandemic [5.9 vs. 5.1%, OR (95%CI) = 0.86 (0.80, 0.92)], but the difference disappeared after multivariable adjustment [adjusted OR (95%CI) = 1.02 (0.94, 1.11)]. Moreover, full term infants born during the pandemic had lower birth weights than those born before the pandemic [adjusted β (95% CI) = −17.4 (−23.9, −10.8)]. Consistently, the risks of low birthweight (LBW, <2,500 g) and small for gestational age (SGA, < P10) were increased [LBW: adjusted OR (95%CI) = 1.13 (1.02, 1.24); SGA: adjusted OR (95%CI) = 1.11 (1.02, 1.21)], and the risks of macrosomia (≥4,000 g) and large for gestational age (LGA, ≥P90) were decreased in the pandemic cohort [macrosomia: adjusted OR (95%CI) = 0.82 (0.77, 0.88); LGA: adjusted OR (95%CI) = 0.73 (0.69, 0.77)].ConclusionIn this study, we observed no change in preterm birth and a decrease in birth weight of full term infants during the pandemic in Nanjing, China.

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Preterm birth rates were slightly lower in Denmark during the first year of the COVID‐19 pandemic compared with the previous 4 years

Cited by 12 publications

References 26 publications

Preterm birth rates among twins during the Danish COVID-19 lockdown and mitigation period

Preterm birth rates among twins during the Danish COVID-19 lockdown and mitigation period

Action is needed to tackle the clinical, psychological and socioeconomic impact of perinatal COVID‐19

Impact of COVID-19 pandemic on birth outcomes: A retrospective cohort study in Nanjing, China

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