Preterm birth: pathogenesis and clinical consequences revisited

Diemert, Anke; Arck, Petra C.

doi:10.1007/s00281-020-00809-w

Cited by 7 publications

(5 citation statements)

References 12 publications

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“…Preterm birth is defined with gestational age less than 37 weeks. Globally, approximately 15 million preterm infants are born per year and preterm birth complications are the leading contributors to the deaths of children under 5 years of age (15,16). Compared to term infants, preterm infants have higher vulnerable body surfaces, and more immature organ systems due to shorter intrauterine time (17).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal changes of lactopontin (milk osteopontin) in term and preterm human milk

Zhu

Bai

et al. 2022

Front. Nutr.

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BackgroundLactopontin (LPN) in breast milk, also known as milk osteopontin is thought to play a myriad of important roles in infants when they are immature. The purpose of the present study was to examine the longitudinal changes in LPN concentrations in term and preterm milk, and elucidate the links between maternal characteristics, LPN levels, and child growth in a birth cohort.Methods131 mothers who delivered term, moderate-late preterm (MPT), very preterm (VPT), and extremely preterm (EPT) infants were included, milk samples were collected at 7, 14, 28, and 120 days postpartum. LPN concentration was determined by multiple reaction monitoring (MRM) using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).ResultsOur results indicated that LPN change over time of VPT (P = 0.024) and EPT (P = 0.003) were significantly different from term milk, although they all gradually decreased with lactation. In terms of LPN-related factors, maternal age was a significant contributor in late mature milk and pre-pregnancy BMI a significant contributor to colostrum and transitional milk. We further investigated relationships between LPN levels and infant weight and our results suggested that high levels of LPN in breast milk might be useful for the catch-up growth of infants.ConclusionLPN levels in breast milk are related to maternal factors, and differences in LPN levels may affect the growth of infants. As milk is a critical part in the mother–breastmilk–infant “triad,” the association between maternal-infant factors and milk LPN levels warrants further study.

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Section: Introductionmentioning

confidence: 99%

Longitudinal changes of lactopontin (milk osteopontin) in term and preterm human milk

Zhu

Bai

et al. 2022

Front. Nutr.

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“…Compared with term infants, preterm infants have higher vulnerable body surfaces and more immature organ systems [2]. Therefore, preterm infants are prone to complications such as dyspnea, jaundice, asphyxia, bleeding, infection [1], and even sustained inflammation [3]. In the worst case scenario, some babies who survive preterm birth still suffer disabilities, such as cerebral palsy, lung disease, blindness, and deafness [1].…”

Section: Introductionmentioning

confidence: 99%

“…The WHO defines newborns with gestational age less than 37 weeks as preterm infants. Globally, approximately 15 million babies are born too early every year, with alarming rates of rising prematurity in most countries [1]. The preterm birth rates are ranging from 5 to 18% in different countries, and the highest premature birth rates are reported in Africa and Asia.…”

Section: Introductionmentioning

confidence: 99%

Preterm birth and human milk proteome: are we ready for individualized fortification?

Zhu

Liu

Xing

2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewPreterm birth is one of the most pressing clinical problems in obstetrics and neonatology worldwide. One of the most sophisticated components of human milk is the proteome and a better understanding of it can lead to precision guides for feeding preterm infants. In this review, we will examine recent research focused on the human milk proteome and individualized protein fortification of human milk. Recent findingsIn both preterm and term birth, the protein content in mother's own milk dropped rapidly in the early postnatal period. Preterm milk had a higher protein content and contained different protein and endogenous peptide compositions compared with term milk. The peptides in gastrointestinal fluids of preterm infants still need further investigation. Individualized fortification is more superior to standard fortification, but it only focuses on the total protein amount. There is no data concerning the composition and posttranslational modifications of proteins and endogenous peptides with fortification and their longterm effects. SummaryComprehensive identification and characterization of the human milk proteome have led to the targeted breast milk fortification theory of preterm infant feeding and has also been enriched by clinical trials. However, to achieve fortification of key proteins and/or endogenous peptides, as standard clinical practice, requires additional studies. Future research should explore the long-term effect of protein fortification and pay more attention to quality rather than quantity in relation to infant body composition and growth outcomes.

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“…El PPT está definido como el parto menor a 37 semanas de gestación y un problema de salud frecuente en ginecoobstetricia en todo el mundo. A pesar de los importantes avances médicos logrados, aproximadamente 15 millones de neonatos nacen con prematuridad (27).…”

Section: Parto Pretérminounclassified

“…Por lo tanto, el PPT es un problema de salud pública de alta prioridad que tiene consecuencias nefastas para la madre, el niño y la sociedad en general. Los bebés que sobreviven a un PPT a menudo enfrentan discapacidades, como parálisis cerebral, enfermedad pulmonar, ceguera y sordera (27).…”

Section: Parto Pretérminounclassified

Factores de riesgo asociados al parto pretérmino en gestantes atendidas en el Hospital Sergio E. Bernales, 2021

Villantoy Vega

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Objetivo: Determinar los factores de riesgo asociados al parto pretérmino en gestantes atendidas en el Hospital Sergio E. Bernales, 2021. Metodología de la investigación: Estudio cuantitativo, diseño de casos y controles y nivel explicativo analítico con una muestra de 186 historias clínicas de gestantes, de las cuales 93 presentaron parto pretérmino y 93 no evidenciaron dicho evento. Asimismo, para dar respuesta a los objetivos se aplicó la prueba de Chi-cuadrado. Resultados: La prevalencia de PPT fue de 11.18%. Los PPT se presentaron con mayor frecuencia en gestantes de 20 a 35 años a comparación de las gestantes con parto a término (X2= 47.73, p=0.00). Las gestantes casadas tuvieron más riesgo de desarrollar PPT (X2= 47.73, p=0.00). El 51.6% de mujeres con PPT asistieron a control prenatal menos de 6 veces, el 52.7% fueron nulíparas, el 54.8% no tuvieron aborto. Tener diabetes gestacional incrementa el riesgo de desarrollar PPT (X2=12.828, p=0.000). Las mujeres con ITU (p=0.004), amenaza de parto pretérmino (p=0.013) y RPM (p=0.013) presentaron mayor riesgo de presentar PPT. Hubo diferencia significativa entre las mujeres con oligohidramnios y en aquellas que no lo presentaron (X2= 10.007, p=0.002). Conclusión: El análisis multivariado identificó que las gestantes con ITU presentaron 1.2 veces más de probabilidad de tener PPT (OR=1.204, IC del 95%: 1.338 - 8.307, p=0.010), considerándose un factor de riesgo.

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Preterm birth: pathogenesis and clinical consequences revisited

Cited by 7 publications

References 12 publications

Longitudinal changes of lactopontin (milk osteopontin) in term and preterm human milk

Longitudinal changes of lactopontin (milk osteopontin) in term and preterm human milk

Preterm birth and human milk proteome: are we ready for individualized fortification?

Factores de riesgo asociados al parto pretérmino en gestantes atendidas en el Hospital Sergio E. Bernales, 2021

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