Preterm birth in rural Malawi: high incidence in ultrasound-dated population

Broek, Nynke van den; Ntonya, Chikonde; Kayira, Edith; White, Sarah; Neilson, James P

doi:10.1093/humrep/dei208

Cited by 46 publications

(54 citation statements)

References 12 publications

(12 reference statements)

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“…[2][3][4][5] Because of a predicted increase in bed net use, we estimated this proportion to be 18% in the control group. Assuming a 10% loss to follow-up, we calculated that a sample size of 440 pregnant women per group would give 80% power at a 5% level of significance to detect a 40% reduction in the rate of preterm delivery (birth before 37 completed gestation weeks).…”

Section: Statistical Analysesmentioning

confidence: 99%

“…[2][3][4][5] In industrialized countries, preterm delivery accounts for 75% of perinatal mortality and a large part of serious neonatal morbidity. 6 Additionally, it is associated with low birth weight (LBW, birth weight less than 2,500 grams) and a variety of more chronic conditions such as impaired lung and eye function, and neurologic and psychological problems.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Repeated Treatment of Pregnant Women with Sulfadoxine-Pyrimethamine and Azithromycin on Preterm Delivery in Malawi: A Randomized Controlled Trial

Luntamo

Kulmala²,

Mbewe³

et al. 2010

The American Society of Tropical Medicine and Hygiene

127

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Abstract. Preterm delivery, which is associated with infections during pregnancy, is common in sub-Saharan Africa. We enrolled 1,320 pregnant women into a randomized, controlled trial in Malawi to study whether preterm delivery and low birth weight (LBW) incidence can be reduced by intermittent preventive treatment of maternal malaria and reproductive tract infections. The participants received either sulfadoxine-pyrimethamine (SP) twice (controls), monthly SP, or monthly SP and two doses of azithromycin (AZI-SP). The incidence of preterm delivery was 17.9% in controls, 15.4% in the monthly SP group ( P = 0.32), and 11.8% in AZI-SP group (risk ratio = 0.66, P = 0.01). Compared with controls, those in AZI-SP group had a risk ratio of 0.61 ( P = 0.02) for LBW. Incidence of serious adverse events was low in all groups. In conclusion, the incidence of preterm delivery and LBW can in some conditions be reduced by treating pregnant women with monthly SP and two azithromycin doses.

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Section: Statistical Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Repeated Treatment of Pregnant Women with Sulfadoxine-Pyrimethamine and Azithromycin on Preterm Delivery in Malawi: A Randomized Controlled Trial

Luntamo

Kulmala²,

Mbewe³

et al. 2010

The American Society of Tropical Medicine and Hygiene

127

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show abstract

“…In the Korle Bu Teaching Hospital prematurity is the cause of almost 54% of early neonatal deaths 2 . Singleton preterm birth rates vary from one part of the world to another: studies have reported rates of 5.5% in New South Wales (Australia) 3 , 9.7% in the USA 4 , 3% in Jordan 5 , 5.4% in Scotland 6 , 15.2% in Zimbabwe 7 and 20.3% in rural Malawi 8 .…”

Section: Introductionmentioning

confidence: 99%

Singleton preterm births in Korle bu teaching hospital, Accra, Ghana – origins and outcomes

Nkyekyer¹,

Enweronu‐Laryea²,

Boafor³

2010

Ghana Medical Journal

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SUMMARYObjective: To determine the singleton preterm birth rate, the relative proportions of the clinical categories of preterm births and to compare the outcomes in these categories. .1%]) were medically indicated (group C). The commonest indication for delivery in group C was severe pre-eclampsia/eclampsia. Although there was no significant difference in the mean gestational ages at delivery between the groups, babies in group C had significantly lower birth weights. No differences in sex ratios, stillbirth rates, or incidence of low Apgar scores were found. Babies in group C were significantly more likely to be admitted to the neonatal intensive care unit (NICU) and had a significantly higher perinatal death rate. Survivors of NICU admission among group C babies spent significantly longer periods in hospital before discharge. Conclusion:Outcomes of preterm births in Korle Bu Teaching Hospital are less favourable among indicated preterm births than among spontaneous or PPROM-related preterm births. A detailed study of the causes of neonatal morbidity and mortality is suggested to determine any differences between the three groups.

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“…Preterm birth accounts for 75% of perinatal mortality and more than half the long-term morbidity world-wide [7]. Although the problem of preterm birth has been well studied in developed countries, data from developing countries especially in Africa is limited [8][9][10]. This study is the first to assess epidemiology of preterm birth in Sudan.…”

Section: Introductionmentioning

confidence: 98%

Epidemiology of preterm birth in Omdurman maternity hospital, Sudan

Alhaj

Radi

Adam

2010

The Journal of Maternal-Fetal & Neonatal Medicine

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Preterm birth in rural Malawi: high incidence in ultrasound-dated population

Abstract: This population has a very high rate of preterm birth, which is probably infection-related. It may be representative of many rural populations in sub-Saharan Africa. Tackling the problem of neonatal mortality in low income countries will require effective methods to prevent preterm birth.

Cited by 46 publications

References 12 publications

Effect of Repeated Treatment of Pregnant Women with Sulfadoxine-Pyrimethamine and Azithromycin on Preterm Delivery in Malawi: A Randomized Controlled Trial

Effect of Repeated Treatment of Pregnant Women with Sulfadoxine-Pyrimethamine and Azithromycin on Preterm Delivery in Malawi: A Randomized Controlled Trial

Singleton preterm births in Korle bu teaching hospital, Accra, Ghana – origins and outcomes

Epidemiology of preterm birth in Omdurman maternity hospital, Sudan

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