Preterm birth: Case definition &amp; guidelines for data collection, analysis, and presentation of immunisation safety data

Quinn, Julie-Anne; Muñoz, Flor M.; Gonik, Bernard; Frau, Lourdes; Cutland, Clare; Moore, Tamala Mallett; Kissou, Aimée; Wittke, Frederick; Das, Manoj; Nunes, Tony; Pye, Savia; Watson, Wendy; Ramos, Ana Maria Alguacil; Cordero, José F.; Huang, Wan‐Ting; Kochhar, Sonali; Buttery, Jim

doi:10.1016/j.vaccine.2016.03.045

Cited by 326 publications

(242 citation statements)

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“…These four phenotypic traits were chosen because of their known relevance in the IUGR pathophysiology. Term birth is defined by the International Classification of Diseases as between 37 (included) and 42 (excluded) weeks (Quinn et al, 2016), otherwise 39.43 ± 2.43 weeks. To simplify, pregnancy term was expressed as a variable named premature birth, computed with the formula:…”

Section: Phenotype Prediction and Network Visualizationmentioning

confidence: 99%

Data-Mining Approach on Transcriptomics and Methylomics Placental Analysis Highlights Genes in Fetal Growth Restriction

et al. 2020

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Intrauterine Growth Restriction (IUGR) affects 8% of newborns and increases morbidity and mortality for the offspring even during later stages of life. Single omics studies have evidenced epigenetic, genetic, and metabolic alterations in IUGR, but pathogenic mechanisms as a whole are not being fully understood. An in-depth strategy combining methylomics and transcriptomics analyses was performed on 36 placenta samples in a case-control study. Data-mining algorithms were used to combine the analysis of more than 1,200 genes found to be significantly expressed and/or methylated. We used an automated text-mining approach, using the bulk textual gene annotations of the discriminant genes. Machine learning models were then used to explore the phenotypic subgroups (premature birth, birth weight, and head circumference) associated with IUGR. Gene annotation clustering highlighted the alteration of cell signaling and proliferation, cytoskeleton and cellular structures, oxidative stress, protein turnover, muscle development, energy, and lipid metabolism with insulin resistance. Machine learning models showed a high capacity for predicting the sub-phenotypes associated with IUGR, allowing a better description of the IUGR pathophysiology as well as key genes involved.

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Section: Phenotype Prediction and Network Visualizationmentioning

confidence: 99%

Data-Mining Approach on Transcriptomics and Methylomics Placental Analysis Highlights Genes in Fetal Growth Restriction

et al. 2020

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“…During the last decades, significant progresses have been made in the management of neonates, in particular for the group of very preterm infants, those born before the 32 nd week (representing 3.6% of all annual births). Changes in clinical practices have led to notable improvements in medical care, including controlled airway pressure, mechanical ventilation or in situ instillation of exogenous surfactant [3][4][5]. With regard to the latter, it is well known that very preterm neonates are lacking the pulmonary surfactant fluid lining the alveolar spaces.…”

Section: -Introductionmentioning

confidence: 99%

On the rheology of pulmonary surfactant: Effects of concentration and consequences for the surfactant replacement therapy

Thai

Mousseau

Oikonomou

et al. 2019

Colloids and Surfaces B: Biointerfaces

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The role of pulmonary surfactant is to reduce the surface tension in the lungs and to facilitate breathing. Surfactant replacement therapy (SRT) aims at bringing a substitute by instillation into the airways, a technique that has proven to be efficient and lifesaving for preterm infants. Adapting this therapy to adults requires to scale the administered dose to the patient body weight and to increase the lipid concentration, whilst maintaining its surface and flow properties similar. Here, we exploit a magnetic wire-based microrheology technique to measure the viscosity of the exogenous pulmonary surfactant Curosurf® in various experimental conditions. The Curosurf® viscosity is found to increase exponentially with lipid concentration following the Krieger-Dougherty law of colloids. The Krieger-Dougherty behavior also predicts a divergence of the viscosity at the liquid-to-gel transition. For Curosurf® the transition concentration is found close to the concentration at which it is formulated (117 g L -1 versus 80 g L -1 ). This outcome suggests that for SRT the surfactant rheological properties need to be monitored and kept within a certain range. The results found here could help in producing suspensions for respiratory distress syndrome adapted to adults. The present work also demonstrates the potential of the magnetic wire microrheology technique as an accurate tool to explore biological soft matter dynamics.

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“…This is supported by a recent review from a high income setting that suggests extremely premature infants and extremely low birth weight infants (<1000g) remain at considerable risk, with a mortality of 30-50% and morbidity of 20-50% in survivors, regardless of technological advances and child health expertise 25 . Current resources in HIC offer the possibility of survival for extreme PTB, but this diverges significantly from resources in LMIC 3 . Overall, this data supports the WHO definition of 28 weeks to define stillbirths 5 , and in our setting, also to differentiate between miscarriage and birth.…”

Section: Discussionmentioning

confidence: 99%

“…The lower limit of extreme preterm shifts between and within countries, and tends to be higher in lower resourced settings [1][2][3] . The World Health Organization (WHO) defines preterm birth (PTB) as any live birth before 37 completed weeks of gestation, which is further subdivided into extreme preterm (<28 weeks), very preterm (28 to <32 weeks) and late preterm (32 to <37 weeks) 4 .…”

Section: Introductionmentioning

confidence: 99%

Miscarriage, stillbirth and neonatal mortality in the extreme preterm birth window of gestation in a limited-resource setting on the Thailand-Myanmar border: A population cohort study

McGready¹,

Paw²,

Wiladphaingern³

et al. 2016

Wellcome Open Res

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The WHO definition of stillbirth uses 28 weeks' gestation as the Background: cut-point, but also defines extreme preterm birth as 24 to <28 weeks' gestation. This presents a problem with the gestational limit of miscarriage, and hence reporting of stillbirth, preterm birth and neonatal death. The objective of this study is to provide a synopsis of the outcome of a population cohort of pregnancies on the Thailand-Myanmar border between 24 to <28 weeks' gestation.Records from the Shoklo Malaria Research Unit Antenatal Clinics Methods: were reviewed for pregnancy outcomes in the gestational window of 24 to <28 weeks, and each record, including ultrasounds reports, were reviewed to clarify the pregnancy outcome. Pregnancies where there was evidence of fetal demise prior to 24 weeks were classified as miscarriage; those viable at 24 weeks' gestation and born before 28 weeks were coded as births, and further subdivided into live-and stillbirth.Between 1995 and 2015, in a cohort of 49,931 women, 0.6% (318) of Results: outcomes occurred from 24 to <28 weeks' gestation, and 35.8% (114) were miscarriages, with confirmatory ultrasound of fetal demise in 45.4% (49/108). Of pregnancies not ending in miscarriage, 37.7% (77/204) were stillborn and of those born alive, neonatal mortality was 98.3% (115/117). One infant survived past the first year of life. Congenital abnormality rate was 12.0% (23/191). Ultrasound was associated with a greater proportion of pregnancy outcome being coded as birth.In this limited-resource setting, pregnancy outcome from 24 to Conclusion:<28 weeks' gestation included: 0.6% of all outcomes, of which one-third were <28 weeks' gestation included: 0.6% of all outcomes, of which one-third were miscarriages, one-third of births were stillborn and mortality of livebirths approached 100%. In the scale-up to preventable newborns deaths, at least initially, greater benefits will be obtained by focusing on the greater number of viable newborns with a gestation of 28 weeks or more.

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Preterm birth: Case definition & guidelines for data collection, analysis, and presentation of immunisation safety data

Cited by 326 publications

References 100 publications

Data-Mining Approach on Transcriptomics and Methylomics Placental Analysis Highlights Genes in Fetal Growth Restriction

Data-Mining Approach on Transcriptomics and Methylomics Placental Analysis Highlights Genes in Fetal Growth Restriction

On the rheology of pulmonary surfactant: Effects of concentration and consequences for the surfactant replacement therapy

Miscarriage, stillbirth and neonatal mortality in the extreme preterm birth window of gestation in a limited-resource setting on the Thailand-Myanmar border: A population cohort study

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