Preterm Birth and Mortality and Morbidity

D’Onofrio, Brian M.; Class, Quetzal A.; Rickert, Martin E.; Larsson, Henrik; Långström, Niklas; Lichtenstein, Paul

doi:10.1001/jamapsychiatry.2013.2107

Cited by 242 publications

(156 citation statements)

References 54 publications

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“…However, Knopik (2009) first proposed that the consequences of SDP would depend on the outcomes being explored, with the associations between SDP and later psychopathology being due to familial confounding. As we recently reviewed elsewhere (D’Onofrio et al, 2013), numerous sibling-comparison studies published in the past several years have all found that familial confounding accounts for most, if not all, of the associations with offspring conduct problems during childhood, disruptive behavior and criminality during adolescence and young adulthood, ADHD, substance use problems, academic difficulties, and lower academic achievement. Although the initial sibling-comparison studies generated controversy because they mostly predicted extreme forms of psychopathology (Talati & Weissman, 2010), more recent sibling-comparison studies, including those focused on more normative outcomes [e.g., substance use during adolescence (D’Onofrio et al, 2012) and measures of early temperament (Ellingson, Goodnight, Van Hulle, Waldman, & D’Onofrio, 2014)], have consistently found that familial factors confound the associations with SDP.…”

Section: Quasi-experimental Studies Of Pregnancy-related Risk Factorsmentioning

confidence: 95%

“…Extensive reviews of the strengths and limitations of each of the designs are available elsewhere (D’Onofrio et al, 2013; Knopik, 2009; Rutter et al, 2001). …”

Section: Review Of Family-based Quasi-experimental Designsmentioning

confidence: 99%

“…Sibling-comparison studies can also be combined with longitudinal assessments; using temporal ordering can help rule out individual-specific genetic confounds when the risk factor (e.g., parental age at childbearing) cannot be influenced by the offspring (Lahey & D’Onofrio, 2010). And, researchers can test for carry-over effects by conducting bidirectional case-crossover studies, which explore differentially exposed siblings across birth order (i.e., the first-versus the second-born child is exposed: D’Onofrio et al, 2013). Other family-based quasi-experimental designs can test additional assumptions of siblings-comparisons.…”

Section: Review Of Family-based Quasi-experimental Designsmentioning

confidence: 99%

“…A recent family-based quasi-experimental study has provided a more nuanced view of the consequences of preterm birth, however (D’Onofrio et al, 2013). Figure 1 presents some of the findings from a sibling-comparison study based on a large population-based sample.…”

Section: Quasi-experimental Studies Of Pregnancy-related Risk Factorsmentioning

confidence: 99%

See 3 more Smart Citations

Testing the Developmental Origins of Health and Disease Hypothesis for Psychopathology Using Family‐Based, Quasi‐Experimental Designs

D’Onofrio

Class

Lahey

et al. 2014

Child Dev Perspectives

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The Developmental Origin of Health and Disease (DOHaD) hypothesis is a broad theoretical framework that emphasizes how early risk factors have a causal influence on psychopathology. Researchers have raised concerns about the causal interpretation of statistical associations between early risk factors and later psychopathology because most existing studies have been unable to rule out the possibility of environmental and genetic confounding. In this paper we illustrate how family-based quasi-experimental designs can test the DOHaD hypothesis by ruling out alternative hypotheses. We review the logic underlying sibling-comparison, co-twin control, offspring of siblings/twins, adoption, and in vitro fertilization designs. We then present results from studies using these designs focused on broad indices of fetal development (low birth weight and gestational age) and a particular teratogen, smoking during pregnancy. The results provide mixed support for the DOHaD hypothesis for psychopathology, illustrating the critical need to use design features that rule out unmeasured confounding.

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Section: Quasi-experimental Studies Of Pregnancy-related Risk Factorsmentioning

confidence: 95%

“…Extensive reviews of the strengths and limitations of each of the designs are available elsewhere (D’Onofrio et al, 2013; Knopik, 2009; Rutter et al, 2001). …”

Section: Review Of Family-based Quasi-experimental Designsmentioning

confidence: 99%

Section: Review Of Family-based Quasi-experimental Designsmentioning

confidence: 99%

Section: Quasi-experimental Studies Of Pregnancy-related Risk Factorsmentioning

confidence: 99%

See 2 more Smart Citations

Testing the Developmental Origins of Health and Disease Hypothesis for Psychopathology Using Family‐Based, Quasi‐Experimental Designs

D’Onofrio

Class

Lahey

et al. 2014

Child Dev Perspectives

Self Cite

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“…One of these potential factors influencing the future likelihood of becoming a parent is the onset of romantic relationships. Studies have indicated that children born preterm were less likely to be in a romantic relationship in early adulthood 63,64 , or ever having been married or in a registered relationships 65 , while children with a low/very low birth weight had a decreased likelihood of having experienced sexual relationships 66 . This may in turn be caused by the reduced likelihood of very low birth weight children to leave the parental home 66 .…”

Section: Childbearing and Pregnancy Outcomementioning

confidence: 99%

Birth Characteristics’ Impacton Future Reproduction and Morbidity Among Twins an dSingletons

Bladh¹

2015

Linköping University Medical Dissertations

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Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring

Sujan

Rickert

Öberg

et al. 2017

JAMA

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182

126

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Importance Prenatal antidepressant exposure has been associated with adverse outcomes. Previous studies, however, may not have adequately accounted for confounding. Objective To evaluate alternative hypotheses for associations between first-trimester antidepressant exposure and birth and neurodevelopmental problems. Design, Setting, and Participants This retrospective cohort study included Swedish offspring born between 1996 and 2012 and followed through 2013 or censored by death or emigration. Analyses controlling for pregnancy, maternal, and paternal covariates, as well as sibling comparisons, timing of exposure comparisons, and paternal comparisons, were used to examine the associations. Exposures Maternal self-reported first-trimester antidepressant use and first-trimester antidepressant dispensations. Main Outcomes and Measures Preterm birth (< 37 gestational weeks), small for gestation age (birth weight < 2 SDs below the mean for gestational age), and first inpatient or outpatient clinical diagnosis of autism spectrum disorder and attention-deficit/hyperactivity disorder in offspring. Results Among 1,580,629 offspring (mean gestational age 279 days; 48.6% female; 1.4% [n = 22,544] with maternal first-trimester self-reported antidepressant use) born to 943,776 mothers (mean age at childbirth 30 years), 7.0% of exposed vs. 4.8% of unexposed offspring were preterm, 2.5% of exposed vs. 2.2% of unexposed were small for gestational age, 5.3% of exposed vs. 2.1% of unexposed were diagnosed with autism spectrum disorder by age 15, and 12.6% of exposed vs. 5.5% of unexposed were diagnosed by attention-deficit/hyperactivity disorder by age 15. At the population level, first-trimester exposure was associated with all outcomes, compared with unexposed offspring (preterm birth: OR = 1.5, 95% CI, [1.4, 1.6]; small for gestational age: OR = 1.2, 95% CI, [1.1, 1.3]; autism spectrum disorder: HR = 2.0, 95% CI, [1.8, 2.3]; attention-deficit/hyperactivity disorder: HR = 2.2, 95% CI, [2.0, 2.4]). However, in models that compared siblings while adjusting for pregnancy, maternal, and paternal traits, first-trimester antidepressant exposure was associated with preterm birth (OR = 1.3, 95% CI [1.2, 1.5]) but not with small for gestational age (OR = 1.0, 95% CI [0.8, 1.3]), autism spectrum disorder (HR = 0.8, 95% CI [0.6, 1.1]), or attention-deficit/hyperactivity disorder (HR = 1.0, 95% CI [0.8, 1.3]). Results from analyses assessing associations with maternal dispensations before pregnancy and paternal first-trimester dispensations were consistent with findings from the sibling comparisons. Conclusion and Relevance Among offspring born in Sweden, after accounting for confounding factors, first-trimester antidepressant exposure, compared to no exposure, was associated with a small increased risk of preterm birth but no increased risk of small for gestational age, autism spectrum disorder, or attention-deficit/hyperactivity disorder.

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Preterm Birth and Mortality and Morbidity

Cited by 242 publications

References 54 publications

Testing the Developmental Origins of Health and Disease Hypothesis for Psychopathology Using Family‐Based, Quasi‐Experimental Designs

Testing the Developmental Origins of Health and Disease Hypothesis for Psychopathology Using Family‐Based, Quasi‐Experimental Designs

Birth Characteristics’ Impacton Future Reproduction and Morbidity Among Twins an dSingletons

Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring

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