Preterm birth and maternal smoking: Risks related to gestational age and onset of delivery

Kyrklund-Blomberg, Nina B.; Cnattingius, Sven

doi:10.1016/s0002-9378(98)70214-5

Cited by 197 publications

(156 citation statements)

References 22 publications

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“…However, as expected, we found that maternal smoking and history of PTB were the main risk factors for PTB in cases. This is in accordance with the present literature [3,5,16,17,20,25]. Conversely, bacterial vaginosis and LLETZ conisation were not associated with PTB in our study, although they represent established risk factors for PTB.…”

Section: Discussionsupporting

confidence: 93%

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

et al. 2013

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Abstract.Oxytocin is crucially involved in the onset and maintenance of labor. We investigated the association between oxytocin receptor gene polymorphisms and preterm birth. The presence of four common oxytocin receptor gene polymorphisms (rs2254298, rs53576, rs2228485 and rs237911) was evaluated in one hundred women with preterm birth and one hundred healthy women using restriction fragment length polymorphism genotyping. No association was found between the presence of any individual oxytocin receptor gene polymorphism and preterm birth. In haplotype analysis, the haplotype combination of rs2254298 A allele, rs2228485 C allele and rs237911 G allele was found to be significantly associated with an increased risk of preterm birth (OR = 3.2 [CI 1.04-9.8], p = 0.043). In conclusion our findings suggest that a combination of three oxytocin receptor gene polymorphisms is associated with an increased risk for preterm birth. We propose further studies investigating the role of oxytocin receptor gene polymorphisms and preterm birth.

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Section: Discussionsupporting

confidence: 93%

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

et al. 2013

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“…Research efforts to address this problem have risen substantially over the past 10 years but have not resulted in improvements in prediction and prevention of preterm delivery (2). The incidence of preterm delivery is associated with various epidemiological and clinical risk factors including a previous preterm birth, periodontal disease, low maternal BMI, smoking, history of induced abortion, anemia, assisted reproduction, multifetal gestation, and other established risk factors, and a good understanding of risk factors may lead to the development of new therapeutic strategies (2,3,4,5,6). Though there have been great advances in our understanding of the molecular and cellular pathways operative in reproductive tissues in the maintenance of uterine quiescence during pregnancy, and in initiating term and preterm labor, our knowledge of the pathophysiology of preterm delivery is limited (7).…”

Section: Introductionmentioning

confidence: 99%

ENDOCRINOLOGY IN PREGNANCY: Thyroid antibodies and risk of preterm delivery: a meta-analysis of prospective cohort studies

Wang

et al. 2012

European Journal of Endocrinology

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Background: Observational studies suggest possible associations between thyroid antibodies and risk of preterm delivery. However, whether thyroid antibodies are risk factors of preterm labor remains controversial. Our goal was to evaluate the associations between thyroid antibodies and risk of preterm delivery by conducting a meta-analysis of prospective cohort studies. Methods: PubMed, Embase, and Wangfang databases were searched through January 2012 to identify studies that met pre-stated inclusion criteria. Data were extracted using standardized forms. Either a fixed-or a random-effects model was used to calculate the overall combined relative ratio (RR) with its corresponding 95% confidence interval (95% CI) to evaluate the relationship between thyroid antibodies and preterm delivery risk. Subgroup analyses were mainly performed by type of thyroid antibodies including thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (TG-Ab). Results: Eleven prospective cohort studies involving 35 467 participants were included. The combined RR of preterm delivery for pregnant women with thyroid antibodies compared with the reference group was 1.41 (95% CI 1.08-1.84, PZ0.011). Subgroup analysis yielded the combined RR of preterm delivery for pregnant women with TPO-Ab compared with the reference group was 1.69 (95% CI 1.19-2.41, PZ0.003), whereas pregnant women with positive TG-Ab had no obvious risk of preterm delivery compared with the reference group (RRZ0.88, 95% CI 0.60-1.29, PZ0.513). Sensitivity analysis restricted to studies excluding women with thyroid dysfunction yielded similar results. Meta-regression analysis suggested that the status of exclusion or inclusion of women with thyroid dysfunction was the major source of heterogeneity in this meta-analysis. No evidence of publication bias was observed. Conclusions: Current evidence suggests that the presence of TPO-Ab in pregnant women significantly increases the risk of preterm delivery.

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“…The severity of preterm birth risk is proportional to the number of cigarettes smoked. The most severe effect appears in women smoking >10 cigarettes daily (29). As the number of cigarettes increases, harm inflicted on women and their babies also increases.…”

Section: Discussionmentioning

confidence: 99%

Smoking status and effects of happiness on smoking in turkish pregnant women

Sonmez¹,

Aksu²

2018

Eur J Ther

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Objective: The aim of this research was to explore smoking during pregnancy, features of pregnant women who smoke, factors that affect smoking during pregnancy, and effects of anxiety and happiness on smoking during pregnancy. Methods: This was a cross-sectional and analytical study. The study was conducted at 16 family health centers in Aydın, Turkey. In total, 187 pregnant women were selected through stratified random sampling. Data were collected using a questionnaire developed by researchers (D.S, H.A,) the Beck Anxiety Inventory, and Oxford Happiness Questionnaire. Data obtained were analyzed using descriptive statistics, Chi-square test, logistic regression analysis, Kolmogorov-Smirnov test, Mann-Whitney U test, and receiver operating characteristic analysis. Results: The rate of smoking was 32.1% before pregnancy and 13.9% during pregnancy. Not having a civil marriage and moving to another place increased smoking. There was a statistically significant difference in the smoking status and the number of cigarettes smoked before and during pregnancy between the groups. Smoking of spouses and other people increased the number of smoking women. There was no statistically significant difference (U=-1.465, p=0.143) between anxiety scores and smoking during pregnancy; however, the difference between happiness scores and smoking during pregnancy was significant (U=-2.804, p=0.005). Conclusion: Feeling happy, smoking spouses or other people around the women, and the number of cigarettes smoked before pregnancy were found to affect smoking during pregnancy.

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Preterm birth and maternal smoking: Risks related to gestational age and onset of delivery

Cited by 197 publications

References 22 publications

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

ENDOCRINOLOGY IN PREGNANCY: Thyroid antibodies and risk of preterm delivery: a meta-analysis of prospective cohort studies

Smoking status and effects of happiness on smoking in turkish pregnant women

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