Preterm birth and low birth weight among in vitro fertilization singletons: A systematic review and meta-analyses

McDonald, Sarah D.; Han, Zhen; Mulla, Sohail; Murphy, Kellie; Beyene, Joseph; Ohlsson, Arne

doi:10.1016/j.ejogrb.2009.05.035

Cited by 336 publications

(208 citation statements)

References 27 publications

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“…This is higher than other reports because our study was restricted to women who were trying to become pregnant, rather than the entire birth population (2). We confirmed the previously reported relationship that singleton infants born to mothers who undergo ART procedures are more likely to be low birthweight (11)(12)(13)(14)(15), preterm (13,14,30), or SGA (13,30,31) than singleton infants born to mothers who did not undergo treatment. We further provide one of a few studies of this size and diversity showing an association between the use of ovulation stimulation medications without ART and infants being born small for gestational age for singleton infants.…”

Section: Discussionsupporting

confidence: 80%

“…In addition to problems associated with multiple gestation deliveries, studies have found that singleton ART-conceived infants are more likely to be low birthweight compared with singletons whose mothers did not use ART (11)(12)(13)(14). Some studies have also found a greater risk of birth defects among singletons and multiples conceived using ART compared with those conceived without treatment (15)(16)(17)(18); however, the evidence is inconsistent and suggests that risk may be related to underlying infertility (19)(20)(21).…”

mentioning

confidence: 91%

See 1 more Smart Citation

Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment

D’Angelo

Whitehead

Helms

et al. 2011

Fertility and Sterility

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Section: Discussionsupporting

confidence: 80%

mentioning

confidence: 91%

Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment

D’Angelo

Whitehead

Helms

et al. 2011

Fertility and Sterility

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“…While ART is an effective means of building a family in those for whom other treatments are unsuccessful, research geared towards defining those aspects of the treatment protocols associated with adverse outcomes continues. Some of the well-described adverse outcomes include multiple gestation, chromosomal abnormalities, birth defects, preterm delivery, small for gestational age/low birth weight infants, preeclampsia, placenta previa, cesarean delivery and perinatal morbidity [1][2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles

Imudia

Goldman

Awonuga

et al. 2013

J Assist Reprod Genet

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Purpose To determine the impact of elevated serum estradiol levels (EE 2 -defined as levels>90th percentile) on the day of hCG administration during IVF on oocyte fertilization, embryo development, implantation, clinical pregnancy and miscarriage rates. Methods A total of 2,995 consecutive IVF cycles in 1,889 patients with non-donor oocyte retrieval resulting in fresh embryo transfer between 1/1/2005 and 12/31/2011 were analyzed. Cycles were stratified by serum E 2 level on the day of hCG administration into those with levels >90th percentile and≤90th percentile. Rates of normal fertilization, embryo development, positive pregnancy test, implantation, clinical pregnancy and spontaneous miscarriage were compared. Results Serum estradiol above the 90th percentile on the day of hCG administration was associated with a significantly lower rate of normal fertilization (68.6±20 vs. 71.6±21, p = 0.02) when compared with patients with a lower serum estradiol threshold. The proportion of embryos that progressed from 2PN to 6-8 cell on day 3 was not different between the two groups. Although rates of positive pregnancy test (55.2 % vs. 57 %), implantation (26.4 % vs. 28.5 %) and clinical pregnancy (45.5 % vs. 49.4 %) were lower in patients with a higher estradiol threshold, these differences were not statistically significant. Similarly, there was no difference in the spontaneous miscarriage rates between the two groups (8.4 % vs. 7.1 %). Conclusions Serum estradiol levels above the 90th percentile on the day of hCG administration is associated with lower oocyte fertilization rate; however, such levels do not impact embryo development, implantation, clinical pregnancy or spontaneous miscarriage rates.

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“…23 Overall, compared with spontaneous conceptions, both ICSI and IVF are associated with lower birth weight, preterm delivery and an increased prevalence of congenital malformations. 24,25 There have also been a variety of medical and psychosocial outcomes examined beyond the perinatal period demonstrating no specific differences between IVFand ICSI-conceived children in growth, 26 neurological, 27,28 cognitive 29 and socio-emotional development 30 and physical health. 31 From here on, this review will present studies that have specifically examined aspects of male infertility, noting that there is limited published material available on offspring outcomes in the presence of male infertility.…”

Section: Introductionmentioning

confidence: 99%

Outcomes for offspring of men having ICSI for male factor infertility

Halliday¹

2011

Asian J Androl

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Since the introduction of intracytoplasmic sperm injection (ICSI) using single sperm isolated from testicular tissue in men with obstructive and non-obstructive azoospermia, or using ejaculated sperm in those with poor semen quality, there have been concerns that this might have adverse effects on the offspring compared to conventional in vitro fertilisation (IVF) and natural conceptions. ICSI is done for reasons other than male factor infertility, and on the whole has not been shown to have any more negative effects than those seen with IVF. There have however, been very few studies of ICSI with a focus on, or large enough numbers to examine, the specific outcomes associated with male factor infertility. From the limited information available in relation to the source of the sperm and aetiology of infertility in the presence of ICSI, there appears to be no increased risk of congenital malformations. There is, however, a small increase in both de novo and inherited chromosome abnormalities. In terms of growth and neurodevelopment, there are very few studies, and so far, no adverse outcomes have been found in young children whose fathers have a sperm defect. The origin of the sperm used in ICSI does not have a major influence on the early life outcomes for the offspring, but transgenerational and epigenetic effects remain unknown. When the male factor infertility is known or thought to be due to a Y-chromosome deletion, this information should be given to the young male offspring at a time that will ensure his own reproductive health and plans are optimized.

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Preterm birth and low birth weight among in vitro fertilization singletons: A systematic review and meta-analyses

Cited by 336 publications

References 27 publications

Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment

Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment

The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles

Outcomes for offspring of men having ICSI for male factor infertility

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