Presynaptic α2-adrenoceptor modulates glutamatergic synaptic transmission in rat nucleus accumbens in vitro

Peng, Shi-Yu; Li, Bin; Xi, Kang; Wang, Jianjun; Zhu, Jing-Ning

doi:10.1016/j.neulet.2017.11.060

Cited by 9 publications

(7 citation statements)

References 52 publications

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“…2L-N). Collectively, these data indicate that NE Heterosynaptic a-ARs are expressed on presynaptic afferents in the NAcSh, with early reports implicating an a 2 -AR-dependent effect on glutamate release probability (Nicola and Malenka, 1998;Peng et al, 2018). To define the synaptic locus recruited by NE signaling at glutamatergic synapses onto PV-INs, we first examined changes in the PPR and CV of EPSCs following multiple pharmacological manipulations.…”

Section: Noradrenergic Control Of Glutamatergic Transmission Occurs At Pv-in But Not Msn Synapsesmentioning

confidence: 90%

“…2B,C,E). We next examined the contribution of a 2 -ARs to the effect of TMx, as prior studies suggest that a 2 -AR activity decreases glutamatergic transmission in the NAc (Peng et al, 2018). In the presence of a 2 -AR-selective antagonist, atipamezole (1 mM), the TMxinduced decrease in EPSC amplitude was completely abolished (TMx in atipamezole: 93.27 6 4.01%, n = 6, p = 0.588; Fig.…”

Section: Noradrenergic Control Of Glutamatergic Transmission Occurs At Pv-in But Not Msn Synapsesmentioning

confidence: 92%

“…However, the functional significance of NE in the NAc is unclear. Ex vivo studies in rat suggest that NE modulates glutamatergic transmission onto medium spiny projection neurons (MSNs) via presynaptic a-ARs (Nicola and Malenka, 1998;Peng et al, 2018). Both a 1 -AR and a 2 -AR subtypes are expressed in the NAc, with ultrastructural analyses showing that a-ARs are expressed at presynaptic and postsynaptic domains in the core and shell (Mitrano et al, 2012;Park et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell

et al. 2021

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The nucleus accumbens shell (NAcSh) receives extensive monoaminergic input from multiple midbrain structures. However, little is known how norepinephrine (NE) modulates NAc circuit dynamics. Using a dynamic electrophysiological approach with optogenetics, pharmacology, and drugs acutely restricted by tethering (DART), we explored microcircuit-specific neuromodulatory mechanisms recruited by NE signaling in the NAcSh of parvalbumin (PV)-specific reporter mice. Surprisingly, NE had little direct effect on modulation of synaptic input at medium spiny projection neurons (MSNs). In contrast, we report that NE transmission selectively modulates glutamatergic synapses onto PV-expressing fast-spiking interneurons (PV-INs) by recruiting postsynaptically-localized a 2 -adrenergic receptors (ARs). The synaptic effects of a 2 -AR activity decrease PV-IN-dependent feedforward inhibition onto MSNs evoked via optogenetic stimulation of cortical afferents to the NAcSh. These findings provide insight into a new circuit motif in which NE has a privileged line of communication to tune feedforward inhibition in the NAcSh.

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Section: Noradrenergic Control Of Glutamatergic Transmission Occurs At Pv-in But Not Msn Synapsesmentioning

confidence: 90%

Section: Noradrenergic Control Of Glutamatergic Transmission Occurs At Pv-in But Not Msn Synapsesmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell

et al. 2021

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“…In support of this hypothesis, previous studies have demonstrated that DA activates presynaptically located D1 or D2 receptors, which leads to a decrease in evoked EPSC/EPSP amplitudes. 15,16) Likewise, NA stimulates presynaptic α2 adrenoceptors, which decreases glutamate release. 17) Additionally, 5-HT decreases the frequency of miniature EPSCs via activation of 5-HT1B receptors, presumably located in presynaptic terminals.…”

Section: Discussionmentioning

confidence: 99%

Acute Cocaine Reduces Excitatory Synaptic Transmission in Pyramidal Neurons of the Mouse Medial Prefrontal Cortex

Sasase

Izumi

Deyama

et al. 2019

Biological & Pharmaceutical Bulletin

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The medial prefrontal cortex (mPFC) plays critical roles in the development of cocaine addiction. Numerous studies have reported about the effects of cocaine on neuronal and synaptic activities in the nucleus accumbens and ventral tegmental area, which are brain regions associated with cocaine addiction; however, a limited number of studies have reported the effect of cocaine on mPFC neuronal activity. In this study, using whole-cell patch-clamp recordings in brain slices, we present that under the condition where synaptic transmission is enhanced by increasing extracellular K concentration, cocaine significantly reduced the frequency but not amplitude of spontaneous excitatory postsynaptic currents. These findings suggest that cocaine exposure could be a trigger to induce hypofrontality, which is related to the compulsive craving for cocaine use.

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“…This may be because the modulation of dopaminergic receptors in this region is regulated by α2 receptors. It was shown in a study that presynaptic located α2 receptors of the NAcs play a role in the modulation of dopaminergic activity in the same region 32 . The reason that agmatine is more effective than L-NAME in jumping behavior maybe due to the effect of the dopaminergic system in this region, regulated by NMDA and presynaptic α2 receptors.…”

Section: Histological Verification and Data Analysismentioning

confidence: 99%

Nukleus akumbens core bölgesinde L-NAME ve agmatinin morfin yoksunluğuna etkileri

Demirkapu¹,

Yananlı²,

Mammadov³

et al. 2020

Namık Kemal Tıp Dergisi

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Presynaptic α2-adrenoceptor modulates glutamatergic synaptic transmission in rat nucleus accumbens in vitro

Cited by 9 publications

References 52 publications

Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell

Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell

Acute Cocaine Reduces Excitatory Synaptic Transmission in Pyramidal Neurons of the Mouse Medial Prefrontal Cortex

Nukleus akumbens core bölgesinde L-NAME ve agmatinin morfin yoksunluğuna etkileri

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