Presynaptic T-Type Ca<sup>2+</sup>Channels Modulate Dendrodendritic Mitral–Mitral and Mitral–Periglomerular Connections in Mouse Olfactory Bulb

Fekete, Ádám; Johnston, Jamie; Delaney, Kerry R.

doi:10.1523/jneurosci.0905-14.2014

Cited by 19 publications

(21 citation statements)

References 57 publications

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“…In this case, the mechanism depends either on spike-waveform through presynaptic Kv3.4 [29 ] or on the increase in basal calcium during subthreshold depolarization via activation of P/Q type calcium channels [30,31]. Modulation of basal calcium concentration by presynaptic membrane potential is also the main mechanism of d-ADF in auditory neurons [32,33], mitral cells of the olfactory bulb [34] and sensory neurons of the Aplysia [35]. However, in granule cells of the dentate gyrus, the mechanism of d-ADF remains unknown [18,36].…”

Section: Analog-digital Signaling In the Axonmentioning

confidence: 99%

Signal propagation along the axon

Rama

Zbili

Debanne

2018

Current Opinion in Neurobiology

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Axons link distant brain regions and are usually considered as simple transmission cables in which reliable propagation occurs once an action potential has been generated. Safe propagation of action potentials relies on specific ion channel expression at strategic points of the axon such as nodes of Ranvier or axonal branch points. However, while action potentials are generally considered as the quantum of neuronal information, their signaling is not entirely digital. In fact, both their shape and their conduction speed have been shown to be modulated by activity, leading to regulations of synaptic latency and synaptic strength. We report here newly identified mechanisms of (1) safe spike propagation along the axon, (2) compartmentalization of action potential shape in the axon, (3) analog modulation of spike-evoked synaptic transmission and (4) alteration in conduction time after persistent regulation of axon morphology in central neurons. We discuss the contribution of these regulations in information processing.

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Section: Analog-digital Signaling In the Axonmentioning

confidence: 99%

Signal propagation along the axon

Rama

Zbili

Debanne

2018

Current Opinion in Neurobiology

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“…Two types of juxtaglomerular interneuron classes -periglomerular (PG) and short axon (SA) cells -are hypothesized to mediate feedforward and lateral inhibition, respectively, with differential impacts on the temporal dynamics of MTC responses (Aungst et al, 2003, Shao et al, 2009, Shirley et al, 2010, Fukunaga et al, 2012, Shao et al, 2012, Liu et al, 2013, Whitesell et al, 2013, Banerjee et al, 2015, Najac et al, 2015, Liu et al, 2016b, Geramita and Urban, 2017. Additionally, feedback inhibition mediated by reciprocal connections between MTCs to PG or SA cells may also shape MTC temporal patterning (Gire and Schoppa, 2009, Fekete et al, 2014, Najac et al, 2015.…”

Section: Introductionmentioning

confidence: 99%

Temporal dynamics of inhalation-linked activity across defined subpopulations of mouse olfactory bulb neurons imaged in vivo

Short

Wachowiak

2019

Preprint

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In mammalian olfaction, inhalation drives the temporal patterning of neural activity that underlies early olfactory processing, and a single inhalation of odorant is sufficient for odor perception. However, how the neural circuits that process incoming olfactory information are activated in the context of inhalation-linked dynamics remains poorly understood. To better understand early olfactory processing in vivo, we used an artificial inhalation paradigm combined with two-photon calcium imaging to compare the dynamics of activity evoked by odorant inhalation across major cell types of the mouse olfactory bulb. Transgenic models and cell-type specific genetic tools were used to express GCaMP6f or jRGECO1a in mitral and tufted cell subpopulations, olfactory sensory neurons and two major juxtaglomerular interneuron classes, and responses to a single inhalation of odorant were compared. Activity in all cell types was strongly linked to inhalation, and all cell types showed some variance in the latency, rise-times and durations of their inhalation-linked response patterns. The dynamics of juxtaglomerular interneuron activity closely matched that of sensory neuron inputs, while mitral and tufted cells showed the highest diversity in dynamics, with a range of latencies and durations that could not be accounted for by heterogeneity in the dynamics of sensory input. Surprisingly, temporal response patterns of mitral and superficial tufted cells were highly overlapping such that these two subpopulations could not be distinguished on the basis of their inhalation-linked dynamics, with the exception of a subpopulation of superficial tufted cells expressing the peptide transmitter cholecystokinin. Overall, these results support a model in which diversity in inhalation-linked patterning of OB output arises first at the level of OSN inputs to the OB and is enhanced by feedforward inhibition from juxtaglomerular interneurons which differentially impacts different subpopulations of OB output neurons.

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“…*P Ͻ 0.05, **P Յ 0.01, and ***P Յ 0.001. PSP) (Awatramani et al 2005;Fekete et al 2014;Ivanov and Calabrese 2003;Ludwar et al 2009;Shapiro et al 1980;Shu et al 2006). In previous experiments we demonstrated that B21-B8 synaptic transmission is potentiated by subthreshold depolarizations.…”

Section: Input Activation and Modulation Of B21-b8 Synaptic Transmissmentioning

confidence: 86%

“…Plasticity mediated via an alteration in the background intracellular Ca 2ϩ concentration ([Ca 2ϩ ] i ) has been reported in other systems (Awatramani et al 2005;Christie et al 2011;Fekete et al 2014;Ivanov and Calabrese 2003;Shu et al 2006). An interesting feature of this type of control is its potentially graded nature.…”

mentioning

confidence: 77%

“…This form of plasticity was originally described Ͼ30 years ago in experiments conducted in Aplysia (e.g., Edmonds et al 1990;Shapiro et al 1980). It has, however, received renewed attention as a result of its identification in mammals (e.g., Awatramani et al 2005;Christie et al 2011;Fekete et al 2014;Shu et al 2006). A goal of ongoing research in this field is to determine how this form of plasticity is invoked under physiologically relevant conditions.…”

Section: Discussionmentioning

confidence: 99%

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Repetition priming-induced changes in sensorimotor transmission

Svensson

Evans

Cropper

2016

Journal of Neurophysiology

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When a behavior is repeated performance often improves, i.e., repetition priming occurs. Although repetition priming is ubiquitous, mediating mechanisms are poorly understood. We address this issue in the feeding network ofAplysia Similar to the priming observed elsewhere, priming inAplysiais stimulus specific, i.e., it can be either "ingestive" or "egestive." Previous studies demonstrated that priming alters motor and premotor activity. Here we sought to determine whether sensorimotor transmission is also modified. We report that changes in sensorimotor transmission do occur. We ask how they are mediated and obtain data that strongly suggest a presynaptic mechanism that involves changes in the "background" intracellular Ca(2+)concentration ([Ca(2+)]i) in primary afferents themselves. This form of plasticity has previously been described and generated interest due to its potentially graded nature. Manipulations that alter the magnitude of the [Ca(2+)]iimpact the efficacy of synaptic transmission. It is, however, unclear how graded control is exerted under physiologically relevant conditions. In the feeding system changes in the background [Ca(2+)]iare mediated by the induction of a nifedipine-sensitive current. We demonstrate that the extent to which this current is induced is altered by peptides (i.e., increased by a peptide released during the repetition priming of ingestive activity and decreased by a peptide released during the repetition priming of egestive activity). We suggest that this constitutes a behaviorally relevant mechanism for the graded control of synaptic transmission via the regulation of the [Ca(2+)]iin a neuron.

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Presynaptic T-Type Ca²⁺Channels Modulate Dendrodendritic Mitral–Mitral and Mitral–Periglomerular Connections in Mouse Olfactory Bulb

Cited by 19 publications

References 57 publications

Signal propagation along the axon

Signal propagation along the axon

Temporal dynamics of inhalation-linked activity across defined subpopulations of mouse olfactory bulb neurons imaged in vivo

Repetition priming-induced changes in sensorimotor transmission

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Presynaptic T-Type Ca2+Channels Modulate Dendrodendritic Mitral–Mitral and Mitral–Periglomerular Connections in Mouse Olfactory Bulb

Cited by 19 publications

References 57 publications

Signal propagation along the axon

Signal propagation along the axon

Temporal dynamics of inhalation-linked activity across defined subpopulations of mouse olfactory bulb neurons imaged in vivo

Repetition priming-induced changes in sensorimotor transmission

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Presynaptic T-Type Ca²⁺Channels Modulate Dendrodendritic Mitral–Mitral and Mitral–Periglomerular Connections in Mouse Olfactory Bulb