Presynaptic regulation of dopaminergic neurotransmission

Schmitz, Yvonne; Benoît-Marand, Marianne; Gonon, François; Sulzer, David

doi:10.1046/j.1471-4159.2003.02050.x

Cited by 181 publications

(154 citation statements)

References 237 publications

(493 reference statements)

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“…Taken together, these results suggest that the mesocortical DA pathway is particularly affected by Nur77 gene ablation, which may be related to the distinct regulation of DA neurotransmission found in the mesocortical pathway relative to the nigrostriatal pathway (Schmitz et al 2003). Indeed, in the striatum, DA levels are under the control of DA autoreceptors located on both axon terminals and somatodendritic areas.…”

Section: Discussionmentioning

confidence: 79%

“…A low dose of quinpirole has been shown to selectively activate autoreceptor functions (Eilam and Szechtman 1989;Schmitz et al 2003). The selective activation of D 2 autoreceptors reduced spontaneous locomotor activity, as opposed to stimulation when postsynaptic D 2 receptors are targeted (Eilam and Szechtman 1989;Schmitz et al 2003).…”

Section: A Presynaptic Mechanism Contributes To Enhanced Locomotion Omentioning

confidence: 99%

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Nur77 Gene Knockout Alters Dopamine Neuron Biochemical Activity and Dopamine Turnover

Gilbert

Morissette

St-Hilaire

et al. 2006

Biological Psychiatry

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Section: Discussionmentioning

confidence: 79%

Section: A Presynaptic Mechanism Contributes To Enhanced Locomotion Omentioning

confidence: 99%

Nur77 Gene Knockout Alters Dopamine Neuron Biochemical Activity and Dopamine Turnover

Gilbert

Morissette

St-Hilaire

et al. 2006

Biological Psychiatry

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“…Dopaminergic transmission is highly regulated presynaptically by autoand heteroreceptors and DA transporters (DATs). The mutual interaction between receptors and DATs provides a complex regulatory system that shapes the DA signal (see Schmitz et al, 2003 for a recent review). Therefore, the interference of higher doses of METH with this regulation is apparently more important than the one exerted by 5 mg/kg METH.…”

Section: Discussionmentioning

confidence: 99%

Single or multiple injections of methamphetamine increased dopamine turnover but did not decrease tyrosine hydroxylase levels or cleave caspase‐3 in caudate‐putamen

Pereira

Lourenço

Borges

et al. 2006

Synapse

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Methamphetamine (METH), leading to striatal dopamine (DA) nerve terminal toxicity in mammals, is also thought to induce apoptosis of striatal neurons in rodents. We investigated the acute effects induced by multiple injections of METH (4 3 5 mg/kg, i.p.) at 2-h intervals or a single injection of METH (20 mg/kg, i.p.) on terminal dopaminergic toxicity markers, including DA levels, DA turnover, and tyrosine hydroxylase (TH) immunoreactivity in rat caudate-putamen (CPu). We further investigated whether both treatment paradigms would change Bax and activate caspase-3 expression, thus triggering striatal apoptotic mitochondria-dependent biochemical cascades. The first injection of METH (5 mg/kg, i.p.) produced a significant release of DA that peaked 30 min and stayed above control levels up to 1.5 h within CPu. In another set of experiments, rats were killed 1 and 24 h following the last injection, for tissue DA and metabolite content measurement and Western blot analysis (24 h). Multiple doses induced DA depletion and increased turnover at both endpoints. Singledose METH reproduced these effects at 24 h; however, turnover was significantly higher than that evoked by the multiple doses at 24 h. Although both paradigms evoked similar DA depletion, however, none of the dosing regimens induced changes in TH expression at 24 h. The former paradigm produced an increase in Bax expression in CPu not sufficient to induce cleavage of caspase-3 proenzyme at 24 h. This study suggests that both paradigm induced changes in striatal dopaminergic markers that are independent of terminal degeneration and striatal apoptotic mitochondria-dependent caspase-3 driven cascade within 24 h.

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“…The proposed mechanism of action is a preferential activation of presynaptic autoreceptors by low-dose dopaminergic activation, which reduces dopamine release (Yamada and Furukawa, 1980;Schmitz et al, 2003). This might also explain the plasticity-abolishing effect of low-dose L-DOPA on inhibitory plasticity.…”

Section: Proposed Mechanisms Of Actionmentioning

confidence: 99%

Dose-Dependent Nonlinear Effect of l-DOPA on Paired Associative Stimulation-Induced Neuroplasticity in Humans

Thirugnanasambandam

Grundey²,

Paulus³

et al. 2011

J. Neurosci.

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Dopamine is one of the major neuromodulators in the CNS, which is involved in learning and memory processes. A nonlinear, inverted U-shaped dose-response curve of its effects on cognition has been observed in animal studies. The basis for this nonlinear effect might be a similar effect of dopamine on neuroplasticity. Whereas it has been shown that dopamine affects paired associative stimulation (PAS)-induced plasticity, which might reflect learning-related processes to a larger degree than other noninvasive plasticity induction protocols in the human motor cortex in principle, its dose-dependency has not been explored previously. We studied the effect of different dosages of the dopamine precursor L-DOPA on motor cortex plasticity induced by facilitatory and inhibitory PAS of the motor cortex in 12 healthy humans. They received 25, 100, or 200 mg of L-DOPA or placebo medication combined with either excitability-enhancing or -diminishing PAS. Cortical excitability level was monitored before and for up to 2 d after plasticity induction by assessment of transcranial magnetic stimulation-induced motor-evoked potentials. Low-dose L-DOPA abolished the aftereffects of PAS and medium-dose L-DOPA prolonged facilitatory plasticity. High-dose L-DOPA reversed the excitability enhancement accomplished by facilitatory PAS to diminution. Thus, the results show a clear nonlinear effect of L-DOPA dosage on associative plasticity, different from that on nonfocal plasticity. This might help to explain dopaminergic effect on cognition and could be relevant for understanding the pathophysiology and treatment of neuropsychiatric diseases accompanied by alterations of the dopaminergic system.

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Presynaptic regulation of dopaminergic neurotransmission

Cited by 181 publications

References 237 publications

Nur77 Gene Knockout Alters Dopamine Neuron Biochemical Activity and Dopamine Turnover

Nur77 Gene Knockout Alters Dopamine Neuron Biochemical Activity and Dopamine Turnover

Single or multiple injections of methamphetamine increased dopamine turnover but did not decrease tyrosine hydroxylase levels or cleave caspase‐3 in caudate‐putamen

Dose-Dependent Nonlinear Effect of l-DOPA on Paired Associative Stimulation-Induced Neuroplasticity in Humans

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