Presynaptic Actions of Botulinum Toxin and β-Bungarotoxin

Simpson, Lance L.

doi:10.1007/978-1-4899-7206-4_7

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Classical 'Monotoxic' Diseases1

Botulism1

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1978

1980

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Cited by 7 publications

(2 citation statements)

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“…In this section I will summarize briefly the present state of knowledge of these classical monotoxic diseases. For detailed information the reader is referred to the following reviews (Singer 1976;Murphy 1976;Bennet & Cuatrecasas 1977;Collier 1977;Bizzini 1977;Simpson 1977).…”

Section: Classical 'Monotoxic' Diseasesmentioning

confidence: 99%

“…There is a substantial body of evidence to support the view that botulinum toxins act on cholinergic nerve endings in the peripheral nervous system but not on the central nervous system. This causes paralysis of both autonomic and neuromuscular transmission (Simpson 1977). The basis for this pathological effect is generally accepted to be due to prevention of release of acetylcholine from cholinergic nerve endings.…”

Section: Botulismmentioning

confidence: 99%

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