Presymptomatic prediction of preeclampsia with angiogenic factors, in high risk pregnant women

Abstract

All angiogenesis factors were effective biomarkers in predicting PE during the second trimester, before the clinical onset of PE.

Predictive value of ophthalmic artery Doppler velocimetry in relation to development of pre‐eclampsia

“…Several recent studies have suggested that as the increased production of anti‐angiogenic molecules such as soluble fms‐like tyrosine kinase‐1 and soluble endoglin, as well as the reduced production of angiogenic molecules such as placental growth factor and vascular endothelial growth factor, have been implicated in the pathogenesis of PE, they therefore might be useful for diagnosis of the disease and its related complications. However, these tests are not accessible to the majority of pregnant women.…”

Placenta Growth Factor and Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia and Normotensive Pregnant Nigerian Women

“…One of such markers is the alterations in maternal serum concentrations of anti-angiogenic (sFlt-1) and pro-angiogenic factors (VEGF and PlGF) [11]. Interestingly, the sFlt-1/PlGF ratio has been demonstrated to show better performance than single markers in predicting the risk of PE [19] [20]. The alteration of the balance between concentration of pro-angiogenic factors, VEGF and PIGF, and anti-angiogenic factors like sFlt-1 and Endoglin has been documented in the pathophysiology of preeclampsia [21].…”

Implementation of the sFlt‐1/PlGF ratio for prediction and diagnosis of pre‐eclampsia in singleton pregnancy: implications for clinical practice

“…These alterations are more pronounced in early‐onset rather than late‐onset disease and are associated with severity of the clinical disorder. Moreover, the disturbances in angiogenic factors are reported to be detectable prior to the onset of clinical symptoms (disease), thereby allowing discrimination of women with normal pregnancies from those at high risk for developing pregnancy complications, primarily PE.…”