Presumptive hepatotoxicity and rhabdomyolysis secondary to phenazopyridine toxicity in a dog

Holahan, Melissa L.; Littman, Meryl P.; Hayes, Cristine L.

doi:10.1111/j.1476-4431.2010.00541.x

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…Inhibition of poly(ADP-ribose) glycohydrolase has been shown to promote apoptosis and impair DNA repair in cells damaged by oxidative stress [60]. Phenazopyridine can cause liver injury [61, 62], while 9-aminoacridine is a DNA intercalator and experimental mutagen [63]. …”

Section: Discussionmentioning

confidence: 99%

A chemical screen identifies small molecules that regulate hepcidin expression

Gaun

Patchen

Volovetz

et al. 2014

Blood Cells, Molecules, and Diseases

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Hepcidin, a peptide hormone produced in the liver, decreases intestinal iron absorption and macrophage iron release via effects on ferroportin. Bone morphogenic protein and Stat3 signaling regulate Hepcidin's transcription. Hepcidin is a potential drug target for patients with iron overload syndromes because its levels are inappropriately low in these individuals. To generate a tool for identifying small molecules that modulate Hepcidin expression, we stably transfected human hepatocytes (HepG2) cells with a reporter construct containing 2.7 kilobases of the human Hepcidin promoter upstream of a firefly reporter gene. We used high throughput methods to screen 10,169 chemicals in duplicate for their effect on Hepcidin expression and cell viability. Regulators were identified as chemicals that caused a change >3 standard deviations above or >1.5 standard deviations below the mean of the other chemicals (z-score >3 or <-1.5), while not adversely affecting cell viability, quantified by fluorescence assay. Following validation assays, we identified 16 chemicals in a broad range of functional classes that promote Hepcidin expression. All of the chemicals identified increased expression of bone morphogenic protein-dependent and/or Stat3-dependent genes, however none of them strongly increased phosphorylation of Smad1,5,8 or Stat3.

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Section: Discussionmentioning

confidence: 99%

A chemical screen identifies small molecules that regulate hepcidin expression

Gaun

Patchen

Volovetz

et al. 2014

Blood Cells, Molecules, and Diseases

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“…Phenazopyridine hydrochloride is used as a human genitourinary analgesic and has been reported to cause ALI in a dog after ingestion of 65 mg/kg. Acetaminophen is a toxic metabolite of phenazopyridine and the mechanism of phenazopyridine's hepatotoxicity is thought to be similar to that of acetaminophen …”

Section: Etiologymentioning

confidence: 99%

Acute liver failure in dogs and cats

Weingarten

Sande

2015

J Vet Emergen Crit Care

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“…Causes for ALF in dogs include drugs/toxins, infections, and neoplasia . In both dogs described here, there was no access to toxins or drugs other than the cheese tree roots.…”

Section: Discussionmentioning

confidence: 93%

“…Causes for ALF in dogs include toxic causes (cycad palms/sago palms, blue‐green algae, Amanita mushroom, aflatoxins, and xylitol), drug reactions (carprofen, acetaminophen, phenazopyridine, phenobarbital, sulphonamides, lomustine, zonisamide, doxycycline, cephalexin, glucosamine, and trimethoprim‐sulfadiazine), infectious agents ( Leptospira and canine adenovirus‐1 [CAV‐1]), and neoplasia (lymphoma, mast cell tumor, and carcinoma) . In most cases, the inciting cause of ALF is unknown.…”

Section: Introductionmentioning

confidence: 99%

Acute liver failure in two dogs following ingestion of cheese tree (Glochidion ferdinandi) roots

Griebsch¹,

Whitney²,

Angles³

et al. 2018

J Vet Emergen Crit Care

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Objective: To describe the management and resolution of acute liver failure (ALF) in two dogs following ingestion of cheese tree (Glochidion ferdinandi) roots. Case Summaries:A 2-year-old male entire Bullmastiff and a 5-year-old female neutered German Shepherd dog were presented for acute-onset lethargy and vomiting after chewing on tree roots of a cheese tree. Both dogs developed clinical abnormalities consistent with ALF, including hepatic encephalopathy, marked increase in alanine aminotransferase activity and bilirubin concentration, and prolonged coagulation times. Treatment included administration of intravenous fluids, hepatoprotectants, vitamin K 1 , antibiotics, lactulose, antacids, antiemetics, and multiple fresh frozen plasma transfusions. Follow-up examinations performed 30 days after initial presentation revealed the dogs to be clinically healthy with serum biochemical and coagulation profiles within reference intervals.New or Unique Information: This is the first report describing ALF in two dogs following ingestion of cheese tree (G. ferdinandi) roots. In this clinical setting, despite a poor prognosis, survival and recovery of adequate liver function were possible with medical management.

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Presumptive hepatotoxicity and rhabdomyolysis secondary to phenazopyridine toxicity in a dog

Cited by 7 publications

References 25 publications

A chemical screen identifies small molecules that regulate hepcidin expression

A chemical screen identifies small molecules that regulate hepcidin expression

Acute liver failure in dogs and cats

Acute liver failure in two dogs following ingestion of cheese tree (Glochidion ferdinandi) roots

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