Presumptive antibiotic therapy for civilian trauma injuries

Hopkins, Teri; Daley, Mitchell J.; Rose, Dusten T.; Jaso, Theresa; Brown, Carlos V R

doi:10.1097/ta.0000000000001164

Cited by 5 publications

(7 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A large proportion of cases of prolonged prophylactic antimicrobial use at the study hospital can be attributed to presumptive antibiotic use ( Figure 1 ). This practice has been reported in previous studies [ 5 , 21 , 22 ].…”

Section: Discussionsupporting

confidence: 55%

“…The presumptive antimicrobial role is relatively new and is controversial with respect to global concerns regarding resistance [ 3 ]. Presumptive antimicrobial use is defined as ‘administration of antimicrobials to prevent infection in trauma patients who already have tissue microbial inoculation, without adequate antimicrobial concentration prior to contamination’ [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has therefore become necessary to develop a standard protocol for presumptive antimicrobial use in resource-constrained settings. The primary indication for presumptive antimicrobials is to forestall frank infection from developing in open wounds [ 5 , 6 ]. This is necessitated by contamination of wounds which, if left, may progress to active infection.…”

Section: Introductionmentioning

confidence: 99%

“…This form of antibiotic therapy is neither targeted nor prophylactic. This novel role of antimicrobials is classed as presumptive use [ 5 ]. Locally, the presumptive antibiotic choice is at the discretion of the surgeon as there are no guidelines in place.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antibiotic use among surgical inpatients at a tertiary health facility: a case for a standardized protocol for presumptive antimicrobial therapy in the developing world

Nnadozie

Umeokonkwo

Maduba

et al. 2020

Infection Prevention in Practice

View full text Add to dashboard Cite

Summary Background Indiscriminate antimicrobial use is one of the greatest contributors to antimicrobial resistance. A low level of asepsis in hospitals and inadequate laboratory support have been adduced as reasons for indiscriminate use of antimicrobials among surgical patients. At present, there are no guidelines for presumptive antibiotic use in Nigeria and sub-Saharan Africa. Aim Surgical inpatients at the study hospital were surveyed to determine the level of antimicrobial use and degree of compliance with prescription quality indicators. Methods A cross-sectional survey was conducted among all surgical inpatients in May 2019 using a standardized tool developed by the University of Antwerp to assess the point prevalence of antimicrobials. Inpatients who were admitted from 08:00 h on the day of the survey were included. Data on patients' demographics, indication for antimicrobial use, reason for antimicrobial use, stop/review date, adherence to guidelines and laboratory use were collected. The prevalence of antimicrobial use in the surgical department was estimated. Results Eighty-two inpatients were included in the survey. Of these, 97.6% were receiving at least one antimicrobial agent. Only 5.4% of the prescriptions were targeted, and 37.6% of prescriptions were for empirical treatment of infections. Approximately half (50.7%) of the patients were receiving presumptive antibiotics, and 6% were receiving prophylactic antibiotics. In total, 58.7% of prescriptions were administered parenterally, and 98.2% of patients had documentation of a stop/review date. Metronidazole ( P =32.3%, T=29.2%), ceftriaxone ( P =28.4%, T=19.8%) and ciprofloxacin ( P =14.2%, T=14.6%) were the most common antimicrobials used. Conclusions There is a high rate of antimicrobial use among surgical inpatients, and the rate of indiscriminate antimicrobial prescribing among these patients needs to be reduced. This can be achieved by developing antimicrobial guidelines for presumptive antimicrobial therapy.

show abstract

Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antibiotic use among surgical inpatients at a tertiary health facility: a case for a standardized protocol for presumptive antimicrobial therapy in the developing world

Nnadozie

Umeokonkwo

Maduba

et al. 2020

Infection Prevention in Practice

View full text Add to dashboard Cite

show abstract

“…Recently, the concept of "presumptive antibiotic therapy" has emerged as a potential solution to antibiotic misuse, which involves prescribing the most sensitive antibiotics to the most common pathogen. 4 It is known that a hospital-based investigation of bacteriological isolates is effective in the identification of common local pathogens and their antibiotic sensitivity patterns. 5 It helps in enhancing presumptive antibiotic therapy and reduces antibiotic misuse, thereby preventing the development of antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

Positive Bacterial Culture among Suspected Orthopedic Infections in a Tertiary Care Centre: A Descriptive Cross-sectional Study

et al. 2022

View full text Add to dashboard Cite

Introduction: A hospital-based investigation of bacteriological isolates helps to identify common causative bacteria and their antibiotic sensitivity patterns. This helps in formulating presumptive antibiotic therapy and in reducing antibiotic misuse. The aim of this study was to find out the prevalence of positive bacterial culture isolates among suspected orthopaedic infections in a tertiary care centre. Methods: A descriptive cross-sectional study was conducted from the electronic data record of the Department of Microbiology of a tertiary care centre from 1 January 2017 to 31 December 2021. The study was conducted following ethical approval from the Institutional Review Committee (Reference number: IRC-2021-11-09-1). Culture reports of suspected orthopaedic infections were evaluated, and those with missing data were excluded. A convenience sampling method was used. Point estimate and 95% Confidence Interval were calculated. Results: Out of 6201 specimens, positive bacterial culture were found in 2957 (47.69%) (46.45-48.93, 95% Confidence Interval). Among them, 1561 (56.01%) were gram-negative organisms and 677 (24.29%) were gram-positive. A total of 2787 (94.25%) were wound/pus swab cultures and 170 (5.74%) were tissue cultures. Conclusions: The prevalence of positive bacterial culture among suspected orthopaedic infections was lower than in other international studies. Among bacteriological isolates, gram-negative organisms are more than gram-positive organisms.

show abstract

Electrohydrodynamic Fabrication of Triple-layered Polycaprolactone Dura Mater Substitute with Antibacterial and Enhanced Osteogenic Capability

Zhu

et al. 2022

Chinese Journal of Mechanical Engineering: Additive Manufacturi

View full text Add to dashboard Cite

Presumptive antibiotic therapy for civilian trauma injuries

Cited by 5 publications

References 73 publications

Antibiotic use among surgical inpatients at a tertiary health facility: a case for a standardized protocol for presumptive antimicrobial therapy in the developing world

Antibiotic use among surgical inpatients at a tertiary health facility: a case for a standardized protocol for presumptive antimicrobial therapy in the developing world

Positive Bacterial Culture among Suspected Orthopedic Infections in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Electrohydrodynamic Fabrication of Triple-layered Polycaprolactone Dura Mater Substitute with Antibacterial and Enhanced Osteogenic Capability

Contact Info

Product

Resources

About