The aim of this review is to present the current knowledge regarding stroke. It appears in three parts (in part I the epidemiology, clinical picture, and risk factors were discussed, while part II dealt with the pathogenesis, investigations, and prognosis). In this part (III) the management is presented. In an acute stroke the role of the following is discussed in detail: Thrombolysis, anticoagulant agents, and prophylactic neuroprotection with pharmacologic agents. For the prevention of stroke apart from the risk factors, which were presented in part I, the current knowledge with pharmacologic agents is discussed. Also the role of carotid endarterectomy, extracranial-intracranial bypass surgery, carotid artery angioplasty and stenting, and the treatment of cerebral hemorrhage are described. Finally the means and possibilities of rehabilitation are discussed.