Prestimulation-induced modulation of the P300 component of event related potentials accompanying startle in children

Sugawara, Masakazu; Sadeghpour, Mojdeh; Traversay, J. De; Ornitz, Edward M.

doi:10.1016/0013-4694(94)90092-2

Cited by 21 publications

(12 citation statements)

References 47 publications

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“…Thus, both sleep polysomnographies (25,26) and the modulation of p300 amplitudes and latencies in acoustically evoked potentials (32) were no dierent in nocturnal enuretics. There was, however, a tendency toward more pathological EEGs among the day wetters.…”

Section: Discussionmentioning

confidence: 87%

Somatic correlates of functional enuresis

Gontard

Benden

Mauer-Mucke

et al. 1999

European Child & Adolescent Psychiatry

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Functional enuresis is a heterogeneous group of syndromes with different aetiology and pathophysiology. The aim was to identify specific somatic correlates of enuresis non-invasively in child psychiatric patients after exclusion of neurologic and structural forms of incontinence. One hundred sixty-seven consecutive children, aged 5 to 10 years with day and/or night wetting were examined prospectively with: urinalysis and bacteriology; ultrasonography, including bladder wall thickness and residual volume; uroflowmetry and pelvic-floor-EMG; EEG; and a complete paediatric-neurologic examination. Day wetting children had a significantly higher rate of previous antibiotic prophylaxis, larger residual volume, thicker bladder walls; the uroflow curves were significantly less bell- and more staccato-shaped, the EMG less relaxed. Voiding postponers showed a tendency towards more uroflow anomalies than urge incontinent children. Primary and secondary enuretics did not differ on most parameters, but primary nocturnal enuretics with micturition problems had significantly less relaxed EMGs than monosymptomatic enuretics. Although day wetters had more pathological EEGs and neurological signs, these differences did not reach significance. The overall rate of urogenital anomalies was 10%. In conclusion, enuresis has a high rate functional somatic correlates with clinical and theoretical, classificatory implications.

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Section: Discussionmentioning

confidence: 87%

Somatic correlates of functional enuresis

Gontard

Benden

Mauer-Mucke

et al. 1999

European Child & Adolescent Psychiatry

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“…The probe N100 reflects early perceptual processing of auditory stimuli and is enhanced when participants are instructed to attend to the startle probe while viewing unpleasant relative to pleasant or neutral pictures (Cuthbert et al, 1998). In addition to the probe N100, the startle probe P300 is a positive deflection of the ERP signal that is maximal at centroparietal sites and occurs approximately 300 ms after the onset of the startle probe (Putnam & Roth, 1990; Roth, Dorato, & Kopell, 1984; Sugawara, Sadeghpour, Traversay, & Ornitz, 1994). The probe P300 reflects attention toward the startle probe and is reduced when viewing emotional relative to neutral pictures due to increased attention to emotional foreground stimuli (leaving less attention allocated to the probe itself) (Bradley, Codispoti, & Lang, 2006; Cuthbert, Schupp, Bradley, McManis, & Lang, 1998; Schupp, Cuthbert, Bradley, Birbaumer, & Lang, 1997).…”

Section: Introductionmentioning

confidence: 99%

Anxiety sensitivity and the anticipation of predictable and unpredictable threat: Evidence from the startle response and event-related potentials

Nelson

Hodges

Hajcak

et al. 2015

Journal of Anxiety Disorders

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There is growing evidence that heightened sensitivity to unpredictable threat is a core mechanism of dysfunction in anxiety disorders. However, it is unclear whether anxiety sensitivity is also associated with sensitivity to unpredictable threat. In the present study, 131 participants completed the Anxiety Sensitivity Index–3, which includes physical concerns (PC), social concerns (SC), and cognitive concerns (CC) subscales, and a predictable vs. unpredictable threat-of-shock task. Startle eyeblink and ERP responses (N100, P300) to the acoustic startle probes were measured during the task. PC and CC were associated with heightened and attenuated, respectively, startle for the unpredictable (but not predictable) condition. CC were also associated with attenuated probe N100 for the unpredictable condition only, and PC were associated with increased P300 suppression across the predictable and unpredictable conditions. This study provides novel evidence that the different anxiety sensitivity dimensions demonstrate unique relationships with the RDoC domains “acute” and “potential” threat.

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“…The amplitude of the P300 startle ERP has been demonstrated to respond to both PPI and PPF, task determinants, as well as allocation of attention, changes in arousal, and emotional context. (see Roth et al, 1982,1984; Putnam and Roth 1987, 1990; Ford and Pfefferbaum, 1991; Suguwara et al, 1994; Hirano et al 1996; Schupp et.al., 1997, Cuthbert et al, 1998; Ornitz et al, 2001). The neural generators of the P300 to startling noises are not entirely known.…”

Section: Introductionmentioning

confidence: 99%

N4 component responses to pre-pulse startle stimuli in young adults: Relationship to alcohol dependence

Ehlers¹,

Phillips²,

Criado³

et al. 2011

Psychiatry Research

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Both physiological and behavioral studies provide evidence to suggest that deficits in frontal cortical control circuits may contribute to the risk for developing alcohol dependence. Event-related potential (ERP) and eye blink responses to startle and short delay prepulse-plus-startle stimuli, and psychiatric diagnoses were investigated in young adult (age 18-30 yrs) men (n=135) and women (n=205) Mexican Americans. Women displayed a significant increase in the amplitude of the eye blink response to both the startle and pre-pulse-plus-startle stimuli. None of the psychiatric diagnoses were associated with differences in eye blink responses. ERP responses to the startle and prepulse-plus startle stimuli included a negative polarity wave at approximately 400ms that was of the highest amplitude in the frontal leads (N4S). Women were found to have significantly higher amplitude N4S responses than men. Participants with alcohol dependence demonstrated significantly less inhibition and more facilitation of the N4S component by the pre-pulse stimuli. This finding was not associated with a diagnosis of: any other drug dependence disorder (including nicotine), anxiety or affective disorder, or conduct/antisocial personality disorder. The present study suggests that gender and a lifetime diagnosis of alcohol dependence may selectively contribute to this frontal late wave electrophysiological response to prepulse-plus-startle stimuli.

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Prestimulation-induced modulation of the P300 component of event related potentials accompanying startle in children

Cited by 21 publications

References 47 publications

Somatic correlates of functional enuresis

Somatic correlates of functional enuresis

Anxiety sensitivity and the anticipation of predictable and unpredictable threat: Evidence from the startle response and event-related potentials

N4 component responses to pre-pulse startle stimuli in young adults: Relationship to alcohol dependence

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