Pressurized liquid extraction with in-cell clean-up followed by gas chromatography–tandem mass spectrometry for the selective determination of parabens and triclosan in indoor dust

Canosa, P.; Pérez-Palacios, David; Garrido-López, Álvaro; Tena, Marı́a Teresa; Rodrı́guez, I.; Rubí, E.; Cela, R.

doi:10.1016/j.chroma.2007.05.089

Cited by 107 publications

(68 citation statements)

References 32 publications

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“…Recently, SBSE also has been applied in soil samples (Casas-Ferreira et al, 2011), for the extraction of some organic compounds, minimizing manipulation of the extracts. We have gone a step beyond by combining PLE with simultaneous in-cell clean-up purification of the extracts, avoiding further manipulation of the sample (Canosa et al, 2007). Finally, determination of both target compounds, TCS and MTCS, can be performed by gas chromatography (GC-MS) (Sánchez-Brunete et al, 2010 andCanosa et al, 2007) or liquid chromatographymass spectrometry (LC-MS) (Zhao et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…We have gone a step beyond by combining PLE with simultaneous in-cell clean-up purification of the extracts, avoiding further manipulation of the sample (Canosa et al, 2007). Finally, determination of both target compounds, TCS and MTCS, can be performed by gas chromatography (GC-MS) (Sánchez-Brunete et al, 2010 andCanosa et al, 2007) or liquid chromatographymass spectrometry (LC-MS) (Zhao et al, 2010). Analyzes of TCS by LC coupled to tandem mass spectrometry (Chu and Metcalfe, 2007;Pedrouzo et al, 2010) or ultra violet detectors (UV) (Cueva-Mestanza et al, 2008) have been reported, although most authors usually employ GC instead as higher resolution and lower detection limits are achieved.…”

Section: Introductionmentioning

confidence: 99%

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Determining the distribution of triclosan and methyl triclosan in estuarine settings

2014

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h i g h l i g h t sSimultaneous extraction of TCS and MTCS by SBSE-LD and PLE-in-cell-clean up. Analysis of estuarine sediment and water samples and from photodegradation assays. Distribution of analytes in estuaries depends on wastewater sources and tides. TCS can be both photodegraded or converted to MTCS in estuaries. a r t i c l e i n f o a b s t r a c tWe have developed a method for the analysis of two sewage-derived contaminants: triclosan (TCS), an antibacterial agent, and methyl triclosan (MTCS), a TCS metabolite. For solid samples (4 g), extraction and cleanup were integrated into the same step using pressurized liquid extraction (PLE) with in-cellclean-up (1 g of florisil). The extraction was performed using dichloromethane at 100°C, 1500 psi and 3 static extraction cycles of 5 min each. For water samples (100 mL), stir bar sorptive extraction-liquid desorption (SBSE-LD) was used. Bars were stirred for 10 h and analytes were later desorbed using acetonitrile. Finally, MTCS and a silylated derivative of TCS were determined by gas chromatography-mass spectrometry (GC-MS). Recovery experiments in water and sediments were performed and the results ranged from 67% to 78%. Limits of detection (LODs) were 5 ng L À1 for TCS and 1 ng L À1 for MTCS, in water samples, and 0.1 ng g À1 for TCS and MTCS in solid samples. The method was applied then to determine the levels of these compounds in the estuary of Guadalete River (SW Spain). TCS and MTCS concentrations up to 9.6 ng g À1 in sediments and 310 ng L À1 in water were measured. Their distribution was strongly influenced by the presence of wastewater sources, treated and untreated, along the sampling area, where maximum concentrations were detected. Highest values were reached in the water column during low tides as the water volume in the estuary becomes lower.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determining the distribution of triclosan and methyl triclosan in estuarine settings

2014

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“…Since the concentrations of these compounds are normally low in aquatic environment, extraction/pretreatment procedures, and high-sensitivity instruments are necessary for their final determination. Their general pretreatment methods reported include liquid-liquid extraction (LLE) [12], dispersive liquid-liquid microextraction (DLLME) [10,11], solid-phase extraction (SPE) [8,13], solid-phase microextraction (SPME) [14], hollow fiber assisted liquid-phase microextraction (HF-LPME) [15], and stir bar sorptive extraction (SBSE) [16]. However, TCC and TCS are not closely related in molecular structure (Fig.…”

Section: Introductionmentioning

confidence: 99%

“…TCC is a weak base with a pK a = 12.77, whereas TCS is a phenolic compound with a pK a = 4.5 [9]. Therefore, these compounds are often analyzed in environmental matrices by using separate methods [8,12,13]. Recently, TCC and TCS have been determined simultaneously in water samples by using DLLME [10,11] or SPME [17] followed by high-performance liquid chromatography with mass spectrometry (HPLC/MS).…”

Section: Introductionmentioning

confidence: 99%

Improved SPE-UPLC-UV-based method for the simultaneous determination of triclocarban and triclosan in wastewater

Liu²,

Wang

2015

Acta Chromatographica

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Summary. Triclocarban (TCC) and triclosan (TCS) are used in a wide range of household and personal care products and have been the most frequently detected organic pollutants in both wastewater and surface water. This paper presented a rapid analytical method for simultaneous determination of TCC and TCS in wastewater. The method involves the extraction and cleanup of the target compounds by using silicon dioxide/polystyrene composite microspheres solid-phase extraction and detection with ultra-high-pressure liquid chromatography. Under the optimized conditions, the limits of detection were 0.028 µg/L and 0.040 µg/L for TCC and TCS, respectively. Under the concentrations of the spiking level ranging from 0.100 µg/L to 2.000 µg/L, the spiked recoveries of TCC and TCS in wastewater samples achieved in the range of 89.5-102.8% with RSD below 6.3% for TCC and 95.5-103.6% with RSD below 6.9% for TCS. This method was successfully used in monitoring the water samples from three traditional wastewater treatment plants.

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“…The literature collected reveals that there are many analytical methods reported of the estimation of parabens alone and together with other drugs or excipients by high-performance liquid chromatography (HPLC), ultra performance liquid chromatography, capillary electrophoresis and gas chromatography mass spectrometry in cosmetics, pharmaceuticals, and environmental samples [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Central Composite Design to Develop a Robust Reversed-Phase Thin-Layer Chromatography/Densitometry Method for Quantification of Parabens in Cosmetic Preparations

Kavitha

Lakshmi

2017

Asian J Pharm Clin Res

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Objective: The current study was framed with a view to develop a simple, sensitive and a rapid reversed-phase thin-layer chromatography (RP-TLC)/ densitometry method for quantification of parabens (methyl, ethyl, propyl, and butyl) in various cosmetic preparations available in local market. Moreover, robustness testing was planned to be performed applying a central composite design (CCD). Methods:The desired chromatographic separation was achieved on RP-TLC/densitometry plates precoated with Silica gel 60 GF 254 on aluminum sheet, employing methanol:toluene:acetonitrile:glacial acetic acid as mobile phase in the ratio of 3:5:1.8:0.2 v/v/v/v and detection was carried out at 256 nm. Results:The mobile phase used gave an excellent resolution of all the four separated parabens. The method was found linear over a wide range of 6.25-400 ng/spot. The optimized method was validated by measuring various validation parameters. CCD was employed to check the robustness of the method at three-factor levels. The developed and optimized method was used to quantify parabens in 30 different cosmetic products procured from local market. Conclusion:The proposed and developed RP-TLC/densitometry method can be applied for routine analysis of all the parabens in cosmetic products and can also be extended to the analysis in pharmaceuticals and food products.

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Pressurized liquid extraction with in-cell clean-up followed by gas chromatography–tandem mass spectrometry for the selective determination of parabens and triclosan in indoor dust

Cited by 107 publications

References 32 publications

Determining the distribution of triclosan and methyl triclosan in estuarine settings

Determining the distribution of triclosan and methyl triclosan in estuarine settings

Improved SPE-UPLC-UV-based method for the simultaneous determination of triclocarban and triclosan in wastewater

Central Composite Design to Develop a Robust Reversed-Phase Thin-Layer Chromatography/Densitometry Method for Quantification of Parabens in Cosmetic Preparations

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