Pressurized liquid extraction: A useful technique to extract pharmaceuticals and personal-care products from sewage sludge

Nieto, Antonio; Borrull, Francesc; Pocurull, Eva; Marcé, Rosa María

doi:10.1016/j.trac.2010.03.014

Cited by 171 publications

(116 citation statements)

References 47 publications

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“…This method is now known by several names; pressurized fluid extraction (PFE), accelerated fluid extraction (ASE), enhanced solvent extraction (ESE), and high pressure solvent extraction (HSPE) (Nieto et al, 2010). The concept of PLE is the application of high pressure to remain solvent liquid beyond their normal boiling point.…”

Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 99%

Techniques for extraction of bioactive compounds from plant materials: A review

Azmir

Zaidul

Rahman

et al. 2013

Journal of Food Engineering

1,943

1,122

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Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 99%

Techniques for extraction of bioactive compounds from plant materials: A review

Azmir

Zaidul

Rahman

et al. 2013

Journal of Food Engineering

1,943

1,122

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“…Pressurized liquid extraction (PLE) which is now known by several names: pressurized fluid extraction (PFE), accelerated fluid extraction (ASE), enhanced solvent extraction (ESE), and high pressure solvent extraction (HSPE) [58]. In this technique of extraction, high pressure in the range of 10 to 15 Mpa is applied over the solvent in contact with source materials.…”

Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 99%

Novel Eco-Friendly Techniques for Extraction of Food Based Lipophilic Compounds from Biological Materials

Ae¹,

Singh²,

Nc³

et al. 2016

Nat Prod Chem Res

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Plant-based lipophilic compounds such as edible oils, phytochemicals, flavors, fragrances and colours are valuable products in the food, pharmaceutical and chemical industry. Extraction is one of the key processing steps in recovering and purifying lipophilic ingredients contained in plant-based materials. Lipophilic compounds are found in the cells of oil bearing plant seeds. Solvent extraction is the most common commercially used extraction method for low oil content materials. Solvent extraction has more extractability than existing commercial methods, but it also passes serious limitations and environmental issues. The Environmental Protection Agency has been much concerned regarding safety and environmental emissions associated with hexane usage in the solvent extraction process. Bio-solvents resulting from renewable raw materials and in particular from the biomass may become a solution of the existing problem. But the existing conventional extraction methods cannot respond to such solvent and hence need for new novel "Green" extraction technology having potential to overcome all limitations of existing technologies. This review will discuss the various possible novel eco-friendly extraction methods, their scientific concepts, principles, challenges, limitations and technological effort needed for successful implementation at the production scale.

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“…Their reproducibility and ability to use smaller total sample volumes mean they will supersede traditional labour intensive SPE protocols in commercial laboratories in the future. Drug determination in the particulate phase of wastewaters is not routinely monitored but those methods which do, use ultrasonic solvent extraction (USE) [36] or most commonly, accelerated solvent extraction (ASE) [30,[37][38][39][40]. The application of pressure enables the use of extraction solvents (eg methanol) at temperatures much higher than their boiling point, increasing solubility and mass transfer [41].…”

Section: Analytical Strategies For Fate Evaluationmentioning

confidence: 99%

Fate of drugs during wastewater treatment

Petrie

McAdam

Scrimshaw

et al. 2013

TrAC Trends in Analytical Chemistry

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Recent trends for the determination of pharmaceutical drugs in wastewaters focus on the development of rapid multi-residue methods. These encompass a large number of drugs (up to 90) of varying physicochemical composition (hydrophobicity, molecular weight etc) at ng l -1 concentrations in the aqueous phase of complex heterogeneous matrices. These are well suited for drug determination in secondary effluents which contain detectable concentrations of pharmaceuticals. Drugs are not routinely monitored for in particulate phases of wastewaters despite being essential for fate determination, particularly in secondary processes receiving relatively high concentrations of suspended solids. Secondary effluents tend to contain multiple drugs, often above their proposed legislative targets for consent. Thus, tertiary processing may be considered to enhance drug removal and provide additional environmental protection. However, current analytical methods do not enable the efficacy of tertiary processes to be fully ascertained due to the inherently lower drug concentrations achieved. Existing method optimisation is required to lower detection capabilities for tertiary process monitoring. This would aid the understanding of breakdown reaction completeness and the criticality between parent drug and degradation product concentrations. Numerous degradation products are formed by biological and chemical processes which can exhibit toxicity. The complimentary use of biological assays here would improve understanding of the synergistic toxicological effect of multiple drugs and their degradation products at low concentration. Additionally, tertiary processes receive secondary effluents comprising comparatively high concentrations of dissolved organics (e.g., colloids). However, knowledge of drug behaviour in the charged colloidal fraction of wastewater and its impact to treatment is limited. Monitoring and understanding here is needed to develop tertiary process diagnosis and optimisation.

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Pressurized liquid extraction: A useful technique to extract pharmaceuticals and personal-care products from sewage sludge

Cited by 171 publications

References 47 publications

Techniques for extraction of bioactive compounds from plant materials: A review

Techniques for extraction of bioactive compounds from plant materials: A review

Novel Eco-Friendly Techniques for Extraction of Food Based Lipophilic Compounds from Biological Materials

Fate of drugs during wastewater treatment

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