Pressure-volume relationships and blood flow in the distended colon

Hanson, KM; Moore, F. W.

doi:10.1152/ajplegacy.1969.217.1.35

Cited by 18 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study reconfirms the observations of several investigators showing that distension interferes with intestinal hemodynamics [1,3,6,7,[13][14][15][16]. While most of the authors reported hemodynamic impairments only for intraluminal pressures higher than 25-30 mm Hg, the present re sults show that an increase in vascular resistance is still observed for in traluminal pressures of near 10 mm Hg.…”

Section: Discussionsupporting

confidence: 92%

Effects of Motility and Luminal Distension on Dog Small Intestine Hemodynamics

Kachelhoffer¹,

Pousse²,

Marescaux³

et al. 1978

Eur Surg Res

View full text Add to dashboard Cite

The effects of spontaneous intestinal motor activity and artificial luminal distension on mesenteric hemodynamics were studied on isolated canine jejunal loops perfused at normothermia under pulsatile flow with heparinized and oxygenated dogs whole blood. To each increase in intestinal tonic activity or intraluminal distension there is a corresponding linear increase in arterial pressure (under constant flow). The hemodynamic effect of distension is less potent than that produced by spontaneous motility. In the luminal pressure range explored (<25 mm Hg) distension does not modify the intestinal O₂ consumption. Spontaneous rhythmic contractions produce oscillations of the venous outflow of the same periodicity as the phasic activity of the bowel and having a magnitude proportional to the strength of the contractions. These results show that intestinal motility or gut lumen distension affects mesenteric hemodynamics by increasing the resistance to blood flow. The linearity of the responses and the absence of any readjustment of the vascular resistance during either tonic contraction or distension seem to indicate a vascular effect resulting only from a mechanical compressing action on the blood vessels. No drastic and irreversible hemodynamic and functional impairments, however, could be observed when the intraluminal pressures involved remain moderate ( < 25 mm Hg). On the other hand the periodic fluctuations of the venous outflow produced by the rhythmic activity may contribute to the mixing and to the propulsion of the mesenteric blood to the portal circulation.

show abstract

Section: Discussionsupporting

confidence: 92%

Effects of Motility and Luminal Distension on Dog Small Intestine Hemodynamics

Kachelhoffer¹,

Pousse²,

Marescaux³

et al. 1978

Eur Surg Res

View full text Add to dashboard Cite

show abstract

“…Parenthetically, it should be noted that the effects of distension whether with saline [1,3,4,7,15] or air [6,14] do not seem to differ as far as diminishing blood flow is concerned. Nevertheless, despite the difference in reported results of enhanced blood flow [11] and reduced blood flow [1,3,4,6,7,8,9,14,15] upon gut distension, there appear to be reasonable explanations. In the experiments by P r ic e et al [11], blood flow of the entire small intestine was measured, whereas the other authors [1,3,4,[6][7][8][9]15] and we recorded only flow to or from a segment with a circum scribed blood supply.…”

Section: Discussionmentioning

confidence: 87%

Effects of Distension and Acetylcholine on Intestinal Blood Flow <i>in vivo</i>

Brobmann¹,

Jacobson²,

Brecher³

1970

J Vasc Res

View full text Add to dashboard Cite

In vivo canine gut segments perfused by branches of the superior mesenteric artery were subjected to increased intraluminal pressure to observe the effects upon arterial inflow, measured with an electromagnetic blood flowmeter, and venous effluent collected by a cannula. Inflation of the intestinal segment with air simultaneously reduced both inflow and outflow. Intra-arterial infusion of acetylcholine increased blood flow, even with intraluminal pressure maintained at 40 mm Hg. Mechanical distension of the gut impedes blood flow, but this effect can be overridden by a vasodilator. These findings correspond to results observed in similar experiments on in vitro gut segments.

show abstract

“…Fleisher [1970] found that iodoacetate, a metabolic poison, produced downward shift of the tension/volume curve of rabbit colon. Hanson and Moore [1969] studied both the rapidly changing ('initial transient') and steady-state ('equilibrium') pressure responses to change in distension. From their figures it would appear that papaverine produced a downward shift of the curve obtained from the values for equilibrium pressure in dog colon.…”

Section: Discussionmentioning

confidence: 99%

Factors Influencing Tone in Rabbit Large Intestine

McKirdy

1978

Exp Physiol

View full text Add to dashboard Cite

Pressure/volume curves obtained in the presence of papaverine have been compared with those obtained under control conditions in rabbit large intestine. Tension/length curves obtained on stimulation of the extrinsic nerve supply to the intestine have been compared with control curves.Evidence is presented for a small contribution of sustained muscular activity to the pressure/ volume and tension/length curves. The effect of stretch on peak tension attained by the intestine has also been examined.

show abstract

Pressure-volume relationships and blood flow in the distended colon

Cited by 18 publications

References 0 publications

Effects of Motility and Luminal Distension on Dog Small Intestine Hemodynamics

Effects of Motility and Luminal Distension on Dog Small Intestine Hemodynamics

Effects of Distension and Acetylcholine on Intestinal Blood Flow <i>in vivo</i>

Factors Influencing Tone in Rabbit Large Intestine

Contact Info

Product

Resources

About