“… 26 Subsequent studies found SP/ESV, peak SP/ESV, or ESPVR predictive for long-term outcomes in various patient cohorts. 27 , 28 , 29 , 30 While we found ESPVR to be significantly associated with MACE in unadjusted Cox regression, other PV loop parameters demonstrated better Wald test and P values, and contractility was therefore not entered into the multivariable model. In summary and coherent with our findings, the inability of the failing ventricle to adapt from rest to stress conditions carries prognostic information.…”