“…All have the potential to cause serious health effects with prolonged exposure or ingestion; all are considered carcinogens by the Agency for Toxic Substances and Disease Registration. Furthermore, long‐term oral exposure and excessive consumption of heavy metals in foodstuffs can lead to diseases such as birth defects, lung, skin, liver, bladder, and kidney cancer, gastrointestinal damage, and even death developed by arsenic (Chowdhury, 2020); Alzheimer's disease and breast cancer by aluminum (Klotz et al, 2017); bone demineralization, severe pulmonary, and gastrointestinal irritant by cadmium (Bernard, 2008); reduced reproductive, taste disorder, and hyposmia by zinc (Reddy et al, 2007); lung disease, heart problems, severe vomiting, stomach ulcers, and diarrhea by antimony (Fujihara & Nishimoto, 2020); gastrointestinal effects (nausea, vomiting, and diarrhea), liver damage, and allergic dermatitis by cobalt (Barreto et al, 2020); acute renal failure, tumor formation, and cancer by germanium (Jinhui & Kui, 1995); kidneys, reproductive system, brain, cause harmful effects on cerebral functioning, infertility, miscarriage, and hypertension by lead (Zounr et al, 2018). The determination of heavy metals in food packaging materials, especially plastics, presents various challenges due to the complexity of the matrix and the extremely low levels of concentration in which the elements are found.…”