Pressure, serotonin, and histamine effects on lung multiple-indicator curves in sheep

Harris, Thomas R.; Brigham, Kenneth L.; Rowlett, R.David

doi:10.1152/jappl.1978.44.2.245

Cited by 37 publications

(4 citation statements)

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“…Patients 30 blood samples were collected at 1.5-2.0-s intervals by allowing blood to flow from a radial artery cannula into heparinized tubes mounted on a precisely timed rotating disc collector. Samples were analyzed exactly as described several times in the literature (9)(10)(11)(12)(13). Briefly, 125I and 51Cr activities were measured in a gamma spectrometer in each blood sample and a sample of the injected mixture.…”

Section: Methodsmentioning

confidence: 99%

Correlation of oxygenation with vascular permeability-surface area but not with lung water in humans with acute respiratory failure and pulmonary edema.

Brigham¹,

Kariman²,

Harris³

et al. 1983

J. Clin. Invest.

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Section: Methodsmentioning

confidence: 99%

Correlation of oxygenation with vascular permeability-surface area but not with lung water in humans with acute respiratory failure and pulmonary edema.

Brigham¹,

Kariman²,

Harris³

et al. 1983

J. Clin. Invest.

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“…From the radioactivity measured in arterial samples and in the injected mixture, we calculated cardiac output and extravascular lung water volume (7,8,16,17). The ['4C]urea permeability surface area product was calculated by two methods: (a) the widely accepted integral extraction calculation (18); and (b) using a Krogh convolution circulatory model (19). The mathematical techniques are described in detail in prior publications (20,21).…”

Section: Experimental Protocolsmentioning

confidence: 99%

Pulmonary Vascular Effects of Fat Emulsion Infusion in Unanesthetized Sheep

McKeen¹,

Brigham²,

Bowers³

et al. 1978

J. Clin. Invest.

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A B S T R A C T Pulmonary diffusing capacity and arterial blood Po2 decrease in humans when 10% fat emulsion is infused. To study its effects on the pulmonary circulation and lung fluid balance, we infused 0.25 g/kg x h of a 10% fat emulsion (Intralipid, Cutter Laboratories, Inc., Berkeley, Calif.) into an awake sheep lung lymph preparation. The emulsion caused a sustained increase in pulmonary artery pressure to approximately twice base line with little change in left atrial pressure. Pa02 decreased an average 13 torr and lung lymph flow increased two-to threefold. Lymph/ plasma total protein concentration fell as lymph flow increased; the magnitude of the lymph/plasma protein decrease was similar to that reported previously when lung vascular pressures were mechanically elevated. Heparin infusion (loading dose = 4,000 U, maintenance dose = 2,000 U/h) cleared the serum of triglycerides but did not alter the response to fat emulsion. Indomethacin infusion (loading dose = 5 mg/kg, maintenance dose = 3 mg/kg x h) blocked the rise in pulmonary artery pressure, the increase in lung lymph flow, and the fall in Pao0. Neither extravascular lung water nor [14C]urea lung vascular permeability surface area products were altered by fat emulsion infusion. We conclude that fat emulsion infusion in sheep increases lung microvascular filtration by increasing vascular pressures, but has no effect on vascular permeability. Since the effects are blocked by indomethacin, they may be prostaglandin mediated.

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“…In particular, the mathematical model estimates of kinetic parameters from pulmonary indicator-dilution data are substantively dependent on assumptions concerning bolus dispersion. The literature reveals that the whole spectrum of assumptions have been used, from the assumption that all dispersion occurs within the arterial tree so that the capillary transport function takes the form of a delta function (19), i.e., all capillaries have one common transit time, to the assumption that the arterial transport function is a delta function with most of the organ dispersion occurring within the capillary bed (17,19). Experimental support for one of these alternatives, or a combination thereof, would be directly useful in providing increased confidence in the estimates.…”

mentioning

confidence: 99%

Transit time dispersion in the pulmonary arterial tree

Clough

Haworth²,

Hanger³

et al. 1998

Journal of Applied Physiology

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Knowledge of the contributions of arterial and venous transit time dispersion to the pulmonary vascular transit time distribution is important for understanding lung function and for interpreting various kinds of data containing information about pulmonary function. Thus, to determine the dispersion of blood transit times occurring within the pulmonary arterial and venous trees, images of a bolus of contrast medium passing through the vasculature of pump-perfused dog lung lobes were acquired by using an X-ray microfocal angiography system. Time-absorbance curves from the lobar artery and vein and from selected locations within the intrapulmonary arterial tree were measured from the images. Overall dispersion within the lung lobe was determined from the difference in the first and second moments (mean transit time and variance, respectively) of the inlet arterial and outlet venous time-absorbance curves. Moments at selected locations within the arterial tree were also calculated and compared with those of the lobar artery curve. Transit times for the arterial pathways upstream from the smallest measured arteries (200-micron diameter) were less than approximately 20% of the total lung lobe mean transit time. Transit time variance among these arterial pathways (interpathway dispersion) was less than approximately 5% of the total variance imparted on the bolus as it passed through the lung lobe. On average, the dispersion that occurred along a given pathway (intrapathway dispersion) was negligible. Similar results were obtained for the venous tree. Taken together, the results suggest that most of the variation in transit time in the intrapulmonary vasculature occurs within the pulmonary capillary bed rather than in conducting arteries or veins.

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Pressure, serotonin, and histamine effects on lung multiple-indicator curves in sheep

Cited by 37 publications

References 0 publications

Correlation of oxygenation with vascular permeability-surface area but not with lung water in humans with acute respiratory failure and pulmonary edema.

Correlation of oxygenation with vascular permeability-surface area but not with lung water in humans with acute respiratory failure and pulmonary edema.

Pulmonary Vascular Effects of Fat Emulsion Infusion in Unanesthetized Sheep

Transit time dispersion in the pulmonary arterial tree

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