Pressure Pain Threshold and Anxiety in Adolescent Females With and Without Juvenile Fibromyalgia

King, Christopher D.; Mano, Kristen E. Jastrowski; Barnett, Kimberly A.; Pfeiffer, Megan; Ting, Tracy V.; Kashikar‐Zuck, Susmita

doi:10.1097/ajp.0000000000000444

Cited by 31 publications

(33 citation statements)

References 52 publications

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“…In a study comparing JFM patients to healthy control, patients with JFM were found more sensitive to pressure pain. They indicated that the results suggest that patients with JFM have a sensitization of peripheral and/or central, like adult fibromyalgia [23]. In the current study, central sensitization values were higher in the group with JFM.…”

Section: Discussionsupporting

confidence: 59%

A preliminary study of the child abuse and central sensitization in adolescent patients with chronic non-organic chest pain and an overlooked condition: juvenile fibromyalgia syndrome

Mansız-Kaplan¹,

Ayhan²,

Cagli³

et al. 2020

Pediatr Rheumatol

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Background: Only a small percentage of pediatric chest pain is of cardiac origin and the most common detected cause is musculoskeletal. Among musculoskeletal causes, acute chest pain is better described, with the causes of chronic pain not being adequately investigated in the literature. The aim of studuy is to evaluate the musculoskeletal causes of non-cardiac chest pain and investigate the relationship of chest pain with child abuse and central sensitization. Methods: Patients aged 12 to 18 years presenting with chest pain for at least 3 months were evaluated by a pediatric cardiologist and those without an organic pathology were referred to the physical medicine and rehabilitation clinic. In addition to detailed history and physical examination, juvenile fibromyalgia was questioned according to the 2016 revised diagnostic criteria of the American College of Rheumatology. The visual analog scale (to measure intensity of chest pain), the Central Sensitization Inventory (to evaluate the presence of central sensitization), the Hospital Anxiety Depression Scale (to determine depression and anxiety), the Childhood Trauma Questionnaire (to assess the presence of child abuse) were administered. Results: The study was completed with 64 patients. Twenty-six percent of patient (n = 17) were diagnosed with juvenile fibromyalgia, and central sensitization was detected in 34.4% (n = 22). Pain intensity, anxiety, depression and abuse scores were higher in patients with juvenile fibromyalgia than those without juvenile fibromyalgia and in patients with central sensitization compared to those without central sensitization (p < 0.001 for both). Higher scores of pain were related with child abuse [beta = 0.763, p < 0.001, (%95 CI, 4.397; 8.841)] and central sensitization of pain [beta = 0.382, p = 0.008 (95% CI: (0.986;6.231)] in regression analyses. Conclusion: In this study, juvenile fibromyalgia was detected as a cause of non-cardiac chest pain. Juvenile fibromyalgia or central sensitization may also indicate childhood abuse.

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Section: Discussionsupporting

confidence: 59%

A preliminary study of the child abuse and central sensitization in adolescent patients with chronic non-organic chest pain and an overlooked condition: juvenile fibromyalgia syndrome

Mansız-Kaplan¹,

Ayhan²,

Cagli³

et al. 2020

Pediatr Rheumatol

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“…PPT is a semi-objective measurement of pain sensitivity, and several studies have shown reduced PPT in chronic pain conditions, especially FM/CWP compared to controls 24,44,49,50 . In agreement with this, we found that PPT was significantly reduced in the FM group compared to CON (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia

Wåhlén

Ernberg

Mannerkorpi

et al. 2020

Sci Rep

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Fibromyalgia (FM) is a complex pain condition where the pathophysiological and molecular mechanisms are not fully elucidated. The primary aim of this study was to investigate the plasma proteome profile in women with FM compared to controls. The secondary aim was to investigate if plasma protein patterns correlate with the clinical variables pain intensity, sensitivity, and psychological distress. Clinical variables/background data were retrieved through questionnaires. Pressure pain thresholds (PPT) were assessed using an algometer. The plasma proteome profile of FM (n = 30) and controls (n = 32) was analyzed using two-dimensional gel electrophoresis and mass spectrometry. Quantified proteins were analyzed regarding group differences, and correlations to clinical parameters in FM, using multivariate statistics. Clear significant differences between FM and controls were found in proteins involved in inflammatory, metabolic, and immunity processes. Pain intensity, PPT, and psychological distress in FM had associations with specific plasma proteins involved in blood coagulation, metabolic, inflammation and immunity processes. This study further confirms that systemic differences in protein expression exist in women with FM compared to controls and that altered levels of specific plasma proteins are associated with different clinical parameters.

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“…Moreover, pain tolerance had an inverse pattern in F‐Dys compared to subjects with major depression. Regarding the relationship between anxiety and pain tolerance, the literature has been controversial on this topic, with reports of decreased pain tolerance in post‐traumatic stress disorder or lack of correlation between anxiety and pain tolerance in patients with juvenile fibromyalgia . Yet, we need to recognize that we did not use measures of state anxiety and depression that have been found to modulate pain perception.…”

Section: Discussionmentioning

confidence: 99%

Pain processing in functional and idiopathic dystonia: An exploratory study

et al. 2018

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Pressure Pain Threshold and Anxiety in Adolescent Females With and Without Juvenile Fibromyalgia

Cited by 31 publications

References 52 publications

A preliminary study of the child abuse and central sensitization in adolescent patients with chronic non-organic chest pain and an overlooked condition: juvenile fibromyalgia syndrome

A preliminary study of the child abuse and central sensitization in adolescent patients with chronic non-organic chest pain and an overlooked condition: juvenile fibromyalgia syndrome

Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia

Pain processing in functional and idiopathic dystonia: An exploratory study

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